Nucleosome Positioning and Spacing: From Mechanism to Function.
Chromatin Assembly and Disassembly
Chromosomal Proteins, Non-Histone
/ chemistry
DNA
/ chemistry
Histones
/ chemistry
Humans
Molecular Dynamics Simulation
Nucleic Acid Conformation
Nucleosomes
/ chemistry
Protein Binding
Protein Conformation, alpha-Helical
Protein Conformation, beta-Strand
Protein Interaction Domains and Motifs
Saccharomyces cerevisiae
/ genetics
Saccharomyces cerevisiae Proteins
/ chemistry
function of nucleosome arrays
nucleosome remodelers
nucleosome spacing
regular nucleosome arrays
transcription
Journal
Journal of molecular biology
ISSN: 1089-8638
Titre abrégé: J Mol Biol
Pays: Netherlands
ID NLM: 2985088R
Informations de publication
Date de publication:
19 03 2021
19 03 2021
Historique:
received:
24
10
2020
revised:
16
01
2021
accepted:
22
01
2021
pubmed:
5
2
2021
medline:
5
5
2021
entrez:
4
2
2021
Statut:
ppublish
Résumé
Eukaryotes associate their genomes with histone proteins, forming nucleosome particles. Nucleosomes regulate and protect the genetic information. They often assemble into evenly spaced arrays of nucleosomes. These regular nucleosome arrays cover significant portions of the genome, in particular over genes. The presence of these evenly spaced nucleosome arrays is highly conserved throughout the entire eukaryotic domain. Here, we review the mechanisms behind the establishment of this primary structure of chromatin with special emphasis on the biogenesis of evenly spaced nucleosome arrays. We highlight the roles that transcription, nucleosome remodelers, DNA sequence, and histone density play towards the formation of evenly spaced nucleosome arrays and summarize our current understanding of their cellular functions. We end with key unanswered questions that remain to be explored to obtain an in-depth understanding of the biogenesis and function of the nucleosome landscape.
Identifiants
pubmed: 33539878
pii: S0022-2836(21)00041-3
doi: 10.1016/j.jmb.2021.166847
pii:
doi:
Substances chimiques
Chromosomal Proteins, Non-Histone
0
Histones
0
Nucleosomes
0
Saccharomyces cerevisiae Proteins
0
DNA
9007-49-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
166847Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interest The authors have no competing interests.