Sexual Dimorphisms, Anti-Hormonal Therapy and Cardiac Arrhythmias.
QT
anticancer drugs
atrial fibrillation
sex
ventricular arrhythmias
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
02 Feb 2021
02 Feb 2021
Historique:
received:
02
01
2021
revised:
21
01
2021
accepted:
27
01
2021
entrez:
5
2
2021
pubmed:
6
2
2021
medline:
13
4
2021
Statut:
epublish
Résumé
Significant variations from the normal QT interval range of 350 to 450 milliseconds (ms) in men and 360 to 460 ms in women increase the risk for ventricular arrhythmias. This difference in the QT interval between men and women has led to the understanding of the influence of sex hormones on the role of gender-specific channelopathies and development of ventricular arrhythmias. The QT interval, which represents the duration of ventricular repolarization of the heart, can be affected by androgen levels, resulting in a sex-specific predilection for acquired and inherited channelopathies such as acquired long QT syndrome in women and Brugada syndrome and early repolarization syndrome in men. Manipulation of the homeostasis of these sex hormones as either hormonal therapy for certain cancers, recreational therapy or family planning and in transgender treatment has also been shown to affect QT interval duration and increase the risk for ventricular arrhythmias. In this review, we highlight the effects of endogenous and exogenous sex hormones in the physiological and pathological states on QTc variation and predisposition to gender-specific pro-arrhythmias.
Identifiants
pubmed: 33540539
pii: ijms22031464
doi: 10.3390/ijms22031464
pmc: PMC7867204
pii:
doi:
Substances chimiques
Gonadal Steroid Hormones
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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