Cooperative Blockade of CK2 and ATM Kinases Drives Apoptosis in VHL-Deficient Renal Carcinoma Cells through ROS Overproduction.
ATM
CK2
HIF-2α
NOX4
ROS pathway
apoptosis
ccRCC
kinase inhibitor
tumor tissue slices
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
02 Feb 2021
02 Feb 2021
Historique:
received:
14
01
2021
revised:
26
01
2021
accepted:
26
01
2021
entrez:
5
2
2021
pubmed:
6
2
2021
medline:
6
2
2021
Statut:
epublish
Résumé
Kinase-targeted agents demonstrate antitumor activity in advanced metastatic clear cell renal cell carcinoma (ccRCC), which remains largely incurable. Integration of genomic approaches through small-molecules and genetically based high-throughput screening holds the promise of improved discovery of candidate targets for cancer therapy. The 786-O cell line represents a model for most ccRCC that have a loss of functional pVHL (von Hippel-Lindau). A multiplexed assay was used to study the cellular fitness of a panel of engineered ccRCC isogenic 786-O VHL
Identifiants
pubmed: 33540838
pii: cancers13030576
doi: 10.3390/cancers13030576
pmc: PMC7867364
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Institut National de la Santé et de la Recherche Médicale
ID : UMR1036
Organisme : Groupement des Entreprises Françaises dans la lutte contre le Cancer
ID : 2018
Organisme : Centre Hospitalier Universitaire de Grenoble Alpes
ID : 2019
Organisme : Ligue Contre le Cancer
ID : Isère
Organisme : Association Française d'Urologie
ID : 2017
Organisme : Labex GRAL
ID : CBH-EURE-GS
Références
Cancer Lett. 2014 Oct 28;353(2):133-44
pubmed: 25069040
Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2121-6
pubmed: 25646414
Genome Biol. 2019 Apr 19;20(1):71
pubmed: 30999927
Cell Cycle. 2010 Dec 15;9(24):4805-11
pubmed: 21150274
Science. 1997 Jan 3;275(5296):90-4
pubmed: 8974401
Mol Cancer Ther. 2012 Apr;11(4):994-1005
pubmed: 22267551
Expert Opin Ther Targets. 2016;20(3):319-40
pubmed: 26565594
J Biomol Screen. 1999;4(2):67-73
pubmed: 10838414
Nat Rev Mol Cell Biol. 2017 May;18(5):277
pubmed: 28377621
Mol Cell. 2020 Aug 6;79(3):504-520.e9
pubmed: 32707033
Cell Mol Life Sci. 2009 Jun;66(11-12):1858-67
pubmed: 19387548
Cancer Cell. 2002 Apr;1(3):237-46
pubmed: 12086860
Crit Rev Biochem Mol Biol. 2014 Jan-Feb;49(1):1-15
pubmed: 24099156
Crit Rev Oncol Hematol. 2000 Nov-Dec;36(2-3):179-92
pubmed: 11033305
Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14391-6
pubmed: 19706526
Nucleic Acids Res. 2019 Jan 8;47(D1):D941-D947
pubmed: 30371878
Br J Cancer. 2015 Jul 14;113(2):336-44
pubmed: 26035699
J Exp Clin Cancer Res. 2019 Jul 5;38(1):287
pubmed: 31277672
Carcinogenesis. 2008 Apr;29(4):713-21
pubmed: 18258605
Nat Chem Biol. 2011 Sep 25;7(11):787-93
pubmed: 21946274
Mol Cancer Ther. 2014 Jul;13(7):1894-906
pubmed: 24825855
J Pathol. 2012 Jun;227(2):146-56
pubmed: 22362593
Clin Cancer Res. 2016 Jun 15;22(12):2840-7
pubmed: 27306791
J Clin Oncol. 2010 Feb 20;28(6):1061-8
pubmed: 20100962
Biochim Biophys Acta. 2008 Jan;1784(1):33-47
pubmed: 17931986
Pharmaceuticals (Basel). 2017 Jan 28;10(1):
pubmed: 28134850
PLoS Biol. 2003 Dec;1(3):E83
pubmed: 14691554
Genes Dev. 2001 Nov 15;15(22):2922-33
pubmed: 11711427
Cell Rep. 2016 Mar 15;14(10):2325-36
pubmed: 26947075
J Urol. 2012 Sep;188(3):707-15
pubmed: 22818130
Mol Cell. 2017 Jun 15;66(6):801-817
pubmed: 28622525
Sci Transl Med. 2012 Jun 6;4(137):137ra75
pubmed: 22674553
Nat Rev Cancer. 2015 Mar;15(3):166-80
pubmed: 25709118
Curr Opin Oncol. 2008 Jan;20(1):83-9
pubmed: 18043261
Oncotarget. 2017 Aug 7;8(44):76770-76782
pubmed: 29100347
EMBO J. 2012 Mar 7;31(5):1080-94
pubmed: 22246186
Nature. 2016 Nov 3;539(7627):107-111
pubmed: 27595393
Mol Cancer Res. 2004 Dec;2(12):712-21
pubmed: 15634760
J Biol Chem. 2017 Apr 21;292(16):6478-6492
pubmed: 28154184
Cancer Res. 2005 Oct 15;65(20):9190-3
pubmed: 16230378
Cancer Res. 2014 Jul 1;74(13):3501-3511
pubmed: 24755467
Oncotarget. 2018 Jul 10;9(53):30066-30078
pubmed: 30046388
Redox Biol. 2019 Jul;25:101084
pubmed: 30612957
Nature. 2016 Nov 3;539(7627):112-117
pubmed: 27595394
J Clin Oncol. 2010 May 1;28(13):2144-50
pubmed: 20368553
Exp Biol Med (Maywood). 2012 Jun;237(6):622-34
pubmed: 22728709
Nucleic Acids Res. 2012 May;40(9):3913-28
pubmed: 22234878
Genome Biol. 2014;15(12):550
pubmed: 25516281
Pharmacol Ther. 2015 May;149:124-38
pubmed: 25512053
J Cell Biol. 2009 Dec 28;187(7):977-90
pubmed: 20026654
Small. 2020 Mar;16(9):e1903899
pubmed: 31747120
J Cell Sci. 2003 Jun 15;116(Pt 12):2377-88
pubmed: 12766184
Antioxid Redox Signal. 2009 Oct;11(10):2429-41
pubmed: 19358632
Redox Biol. 2014 Feb 23;2:535-62
pubmed: 24634836
Sci Signal. 2010 Sep 21;3(140):ra67
pubmed: 20858866
Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2349-54
pubmed: 24469833
Nat Med. 2020 Oct;26(10):1519-1530
pubmed: 33020645
Nat Rev Cancer. 2014 Nov;14(11):709-21
pubmed: 25342630
Proc Natl Acad Sci U S A. 2010 May 4;107(18):8352-6
pubmed: 20404174
Cell Rep. 2014 Dec 11;9(5):1703-1717
pubmed: 25464843
Nature. 2019 Apr;568(7753):511-516
pubmed: 30971826
Sci Rep. 2018 Jul 18;8(1):10888
pubmed: 30022091
Am J Pathol. 2012 Jan;180(1):24-31
pubmed: 22056359
Br J Cancer. 2003 Feb 10;88(3):463-9
pubmed: 12569392
J Cell Biochem. 2014 Dec;115(12):2103-15
pubmed: 25043911
Biochem J. 2004 Nov 1;383(Pt. 3):429-37
pubmed: 15239670
Cancer Cell. 2006 Sep;10(3):175-6
pubmed: 16959608
Nat Chem Biol. 2017 Jun;13(6):616-623
pubmed: 28346404
Cancers (Basel). 2020 Jan 17;12(1):
pubmed: 31963500
J Biol Chem. 2002 Jun 28;277(26):23508-14
pubmed: 11983697
J Biomed Biotechnol. 2012;2012:170325
pubmed: 22911014
Proc Natl Acad Sci U S A. 2010 May 11;107(19):8788-93
pubmed: 20421486
Biochim Biophys Acta. 2010 Mar;1804(3):499-504
pubmed: 19665589
J Med Chem. 2011 Jan 27;54(2):635-54
pubmed: 21174434
Nature. 2003 Sep 18;425(6955):307-11
pubmed: 13679920
Nat Rev Cancer. 2008 Nov;8(11):865-73
pubmed: 18923434
Lancet Oncol. 2009 Oct;10(10):992-1000
pubmed: 19796751
Nature. 2015 Nov 12;527(7577):186-91
pubmed: 26466563
Chemosphere. 2021 Feb;264(Pt 1):128468
pubmed: 33032228
Biochem J. 2016 Dec 15;473(24):4527-4550
pubmed: 27941030
Cancer Cell. 2021 Jan 11;39(1):38-53.e7
pubmed: 33217343
Pharmaceuticals (Basel). 2020 Oct 05;13(10):
pubmed: 33027921
Oncogene. 2014 Jun 26;33(26):3351-60
pubmed: 23851492
Oxid Med Cell Longev. 2017;2017:1485283
pubmed: 28698765
N Engl J Med. 2007 Jan 11;356(2):115-24
pubmed: 17215529
Nat Rev Cancer. 2003 Mar;3(3):155-68
pubmed: 12612651
Cancer Cell. 2020 Aug 10;38(2):167-197
pubmed: 32649885
Cell. 2013 Mar 14;152(6):1344-54
pubmed: 23498941
Nat Methods. 2014 Aug;11(8):783-784
pubmed: 25075903
World J Urol. 2018 Dec;36(12):1913-1926
pubmed: 30123932
Biochim Biophys Acta. 2016 Dec;1863(12):2977-2992
pubmed: 27646922
J Cell Sci. 2002 Oct 15;115(Pt 20):3873-8
pubmed: 12244125
Biomed Rep. 2020 Dec;13(6):55
pubmed: 33082952
Cell Calcium. 2016 Aug;60(2):108-14
pubmed: 26995054
Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8010-4
pubmed: 10869423
Cancer Discov. 2011 Aug;1(3):222-35
pubmed: 22037472
Cell Metab. 2006 Nov;4(5):337-8
pubmed: 17084707
Oncogene. 2008 Aug 28;27(37):4986-97
pubmed: 18469858
Nat Chem Biol. 2008 Nov;4(11):674-81
pubmed: 18936752
Front Oncol. 2020 Jun 18;10:893
pubmed: 32626654
Nat Rev Nephrol. 2017 Aug;13(8):496-511
pubmed: 28691713
Oncotarget. 2017 Dec 19;9(5):5736-5751
pubmed: 29464030
Biol Chem. 2007 Apr;388(4):391-8
pubmed: 17391060
Cell Mol Life Sci. 2016 Aug;73(15):2829-50
pubmed: 26791483
Cell Death Dis. 2016 Jun 09;7(6):e2253
pubmed: 27277675
Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18631-6
pubmed: 25512513
J Cell Biochem. 2015 May;116(5):696-703
pubmed: 25546605
Leukemia. 2014 Jan;28(1):179-82
pubmed: 23925046
Cancer Lett. 2012 Sep 1;322(1):113-8
pubmed: 22387988
J Cancer Res Clin Oncol. 2002 Oct;128(10):561-8
pubmed: 12384800
Biochem J. 2003 Jan 1;369(Pt 1):1-15
pubmed: 12396231
Lancet. 2011 Dec 3;378(9807):1931-9
pubmed: 22056247
Nat Rev Immunol. 2004 Mar;4(3):181-9
pubmed: 15039755
Cancer Res. 2016 Sep 15;76(18):5491-500
pubmed: 27635045
N Engl J Med. 2007 Jan 11;356(2):125-34
pubmed: 17215530
Cancer Res. 1991 Feb 1;51(3):794-8
pubmed: 1846317
Nature. 2001 Mar 1;410(6824):50-6
pubmed: 11242036
Cell Mol Life Sci. 2020 Nov;77(22):4459-4483
pubmed: 32358622
Int J Biol Sci. 2015 Feb 23;11(4):411-22
pubmed: 25798061
Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3110-5
pubmed: 9096354
Cytometry A. 2005 Nov;68(1):1-9
pubmed: 16184611
Cancer Cell. 2013 Oct 14;24(4):410-21
pubmed: 24135279
Blood. 2020 Sep 24;136(13):1520-1534
pubmed: 32396934
J Biotechnol. 2010 Jul 1;148(1):3-15
pubmed: 20097238
J Clin Oncol. 2005 Jan 1;23(1):133-41
pubmed: 15625368
Mol Cancer Res. 2011 Sep;9(9):1255-65
pubmed: 21798997
J Biol Chem. 1999 Nov 12;274(46):32631-7
pubmed: 10551817
Oncology. 2013;85(1):8-13
pubmed: 23797151
Nat Rev Cancer. 2002 Sep;2(9):673-82
pubmed: 12209156
EMBO J. 2019 Aug 1;38(15):e101654
pubmed: 31282586
Cancer Cell. 2016 Oct 10;30(4):515-517
pubmed: 27728802
PLoS One. 2014 Dec 26;9(12):e115609
pubmed: 25541719
Exp Cell Res. 2017 Jul 15;356(2):116-121
pubmed: 28315322
J Clin Invest. 2015 May;125(5):1780-9
pubmed: 25932675
Int J Cancer. 2005 Dec 10;117(5):764-74
pubmed: 15957168
Mol Cell Biol. 2004 Jul;24(13):6011-20
pubmed: 15199154
Oncotarget. 2016 Jun 28;7(26):39444-39457
pubmed: 27276705