Alcohol Intake and Alcohol-SNP Interactions Associated with Prostate Cancer Aggressiveness.
SNP interaction
alcohol intake
prostate cancer
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
02 Feb 2021
02 Feb 2021
Historique:
received:
03
12
2020
revised:
25
01
2021
accepted:
28
01
2021
entrez:
5
2
2021
pubmed:
6
2
2021
medline:
6
2
2021
Statut:
epublish
Résumé
Excessive alcohol intake is a well-known modifiable risk factor for many cancers. It is still unclear whether genetic variants or single nucleotide polymorphisms (SNPs) can modify alcohol intake's impact on prostate cancer (PCa) aggressiveness. The objective is to test the alcohol-SNP interactions of the 7501 SNPs in the four pathways (angiogenesis, mitochondria, miRNA, and androgen metabolism-related pathways) associated with PCa aggressiveness. We evaluated the impacts of three excessive alcohol intake behaviors in 3306 PCa patients with European ancestry from the PCa Consortium. We tested the alcohol-SNP interactions using logistic models with the discovery-validation study design. All three excessive alcohol intake behaviors were not significantly associated with PCa aggressiveness. However, the interactions of excessive alcohol intake and three SNPs (rs13107662 [
Identifiants
pubmed: 33540941
pii: jcm10030553
doi: 10.3390/jcm10030553
pmc: PMC7867322
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NCI NIH HHS
ID : R21 CA202417
Pays : United States
Organisme : NCI NIH HHS
ID : R21CA202417
Pays : United States
Déclaration de conflit d'intérêts
All authors disclosed no potential conflicts of interest.
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