Transcriptome-Guided Design of Physiological Multilineage Liver Organoids.
gene regulatory network
human induced pluripotent stem cell
organogenesis
Journal
Trends in genetics : TIG
ISSN: 0168-9525
Titre abrégé: Trends Genet
Pays: England
ID NLM: 8507085
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
20
01
2021
accepted:
22
01
2021
pubmed:
6
2
2021
medline:
2
9
2021
entrez:
5
2
2021
Statut:
ppublish
Résumé
Despite several technical challenges, human induced pluripotent stem cell (hiPSC)-derived organoids enable biologically and clinically relevant functional study of physiology and disease. In a recent Cell Systems article, Velazquez et al. report a novel strategy to identify regulators of multilineage organoid maturation by reverse-engineering from the global transcriptome of human tissues.
Identifiants
pubmed: 33541711
pii: S0168-9525(21)00025-1
doi: 10.1016/j.tig.2021.01.007
pmc: PMC9037672
mid: NIHMS1798100
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
403-404Subventions
Organisme : European Research Council
ID : 671231
Pays : International
Organisme : NCI NIH HHS
ID : R01 CA233794
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK099558
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA226052
Pays : United States
Commentaires et corrections
Type : CommentOn
Informations de copyright
Copyright © 2021. Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
Declaration of Interests No interests are declared.
Références
Int J Mol Sci. 2018 Mar 21;19(4):
pubmed: 29561796
Front Physiol. 2020 Aug 28;11:990
pubmed: 32982772
Cell. 2016 Jun 16;165(7):1586-1597
pubmed: 27315476
Drug Discov Today. 2019 Jun;24(6):1248-1257
pubmed: 30940562
Nat Mater. 2021 Jan;20(1):22-29
pubmed: 32958879
Cell Syst. 2021 Jan 20;12(1):41-55.e11
pubmed: 33290741
Elife. 2019 Aug 27;8:
pubmed: 31451149
Hepatology. 2020 Sep;72(3):1085-1101
pubmed: 31899548
Nat Commun. 2016 Jan 06;7:10243
pubmed: 26732624