Nasopharyngeal SARS-CoV-2 viral loads in young children do not differ significantly from those in older children and adults.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
04 02 2021
Historique:
received: 30 10 2020
accepted: 13 01 2021
entrez: 5 2 2021
pubmed: 6 2 2021
medline: 17 2 2021
Statut: epublish

Résumé

The role of children in the spread of the SARS-CoV-2 coronavirus has become a matter of urgent debate as societies in the US and abroad consider how to safely reopen schools. Small studies have suggested higher viral loads in young children. Here we present a multicenter investigation on over five thousand SARS-CoV-2 cases confirmed by real-time reverse transcription (RT) PCR assay. Notably, we found no discernable difference in amount of viral nucleic acid among young children and adults.

Identifiants

pubmed: 33542262
doi: 10.1038/s41598-021-81934-w
pii: 10.1038/s41598-021-81934-w
pmc: PMC7862672
doi:

Substances chimiques

RNA, Viral 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3044

Subventions

Organisme : NHLBI NIH HHS
ID : K23 HL138461
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007641
Pays : United States

Références

JAMA Pediatr. 2020 Sep 1;174(9):902-903
pubmed: 32745201
Lancet Infect Dis. 2020 Jun;20(6):656-657
pubmed: 32199493
BMJ Paediatr Open. 2020 Jun 21;4(1):e000722
pubmed: 32596514
Nat Med. 2020 May;26(5):672-675
pubmed: 32296168
Clin Infect Dis. 2020 Aug 21;:
pubmed: 32821935
EClinicalMedicine. 2020 Jun 26;24:100433
pubmed: 32766542
Nature. 2020 May;581(7807):127-128
pubmed: 32382119

Auteurs

Sharline Madera (S)

Division of Infectious Diseases, Department of Medicine, University of California, San Francisco, CA, USA. sharline.madera@ucsf.edu.

Emily Crawford (E)

Chan-Zuckerberg Biohub, San Francisco, CA, USA.
Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA.
Department of Medicine and Biochemistry & Biophysics, University of California San Francisco, San Francisco, CA, USA.

Charles Langelier (C)

Division of Infectious Diseases, Department of Medicine, University of California, San Francisco, CA, USA.
Chan-Zuckerberg Biohub, San Francisco, CA, USA.

Nam K Tran (NK)

Department of Pathology and Laboratory Medicine, Davis School of Medicine, University of California, Sacramento, CA, USA.

Ed Thornborrow (E)

Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA.

Steve Miller (S)

Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA.

Joseph L DeRisi (JL)

Chan-Zuckerberg Biohub, San Francisco, CA, USA.
Department of Medicine and Biochemistry & Biophysics, University of California San Francisco, San Francisco, CA, USA.

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Classifications MeSH