Transdermal Estrogen Therapy Improves Gains in Skeletal Muscle Mass After 12 Weeks of Resistance Training in Early Postmenopausal Women.
estradiol
exercise
hormone replacement therapy
menopause
muscle hypertrophy
muscle strength
strength training
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2020
2020
Historique:
received:
07
10
2020
accepted:
30
11
2020
entrez:
5
2
2021
pubmed:
6
2
2021
medline:
6
2
2021
Statut:
epublish
Résumé
Women show an accelerated loss of muscle mass around menopause, possibly related to the decline in estrogen. Furthermore, the anabolic response to resistance exercise seems to be hampered in postmenopausal women. We aimed to test the hypothesis that transdermal estrogen therapy (ET) amplifies the skeletal muscle response to resistance training in early postmenopausal women. A double-blinded randomized controlled study. Department of Public Health, Aarhus University, Denmark. Thirty-one healthy, untrained postmenopausal women no more than 5 years past menopause. Supervised resistance training with placebo (PLC, The primary outcome parameter was a cross-sectional area of quadriceps femoris measured by magnetic resonance imaging, and secondary parameters were fat-free mass (dual-energy X-ray absorptiometry), muscle strength, and functional tests. The increase in muscle cross-sectional area was significantly greater in the ET group (7.9%) compared with the PLC group (3.9%) ( The use of transdermal ET enhanced the increase in muscle mass in response to 12 weeks of progressive resistance training in early postmenopausal women.
Identifiants
pubmed: 33542694
doi: 10.3389/fphys.2020.596130
pmc: PMC7853242
doi:
Types de publication
Journal Article
Langues
eng
Pagination
596130Informations de copyright
Copyright © 2021 Dam, Dalgaard, Ringgaard, Johansen, Bisgaard Bengtsen, Mose, Lauritsen, Ørtenblad, Gravholt and Hansen.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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