Dihydropyrimidine Dehydrogenase Deficiency: To Screen or Not to Screen?
Journal
Journal of the advanced practitioner in oncology
ISSN: 2150-0878
Titre abrégé: J Adv Pract Oncol
Pays: United States
ID NLM: 101550346
Informations de publication
Date de publication:
Historique:
entrez:
5
2
2021
pubmed:
6
2
2021
medline:
6
2
2021
Statut:
ppublish
Résumé
5-fluorouracil (5-FU) and its prodrug capecitabine are frequently prescribed in oncology. While usually well tolerated, toxicity can be severe, and even life-threatening. A dihydropyrimidine dehydrogenase (DPD) deficiency can cause severe toxicity. Current testing for DPD deficiency does not meet the criteria for a routine screening test prior to 5-FU therapy. A case study of a fatality secondary to capecitabine toxicity is reviewed and literature is examined regarding general screening for DPD deficiency.
Identifiants
pubmed: 33542850
doi: 10.6004/jadpro.2020.11.1.4
pii: 2020.11.1.4
pmc: PMC7517765
doi:
Types de publication
Journal Article
Langues
eng
Pagination
68-73Informations de copyright
© 2020 Harborside™.
Déclaration de conflit d'intérêts
The author has no conflicts of interest to disclose.
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