5'ValCAC tRNA fragment generated as part of a protective angiogenin response provides prognostic value in amyotrophic lateral sclerosis.
amyotrophic lateral sclerosis
angiogenin
biomarker
tRNA fragment
tiRNA
Journal
Brain communications
ISSN: 2632-1297
Titre abrégé: Brain Commun
Pays: England
ID NLM: 101755125
Informations de publication
Date de publication:
2020
2020
Historique:
received:
30
03
2020
revised:
02
07
2020
accepted:
19
06
2020
entrez:
5
2
2021
pubmed:
6
2
2021
medline:
6
2
2021
Statut:
epublish
Résumé
Loss-of-function mutations in the ribonuclease angiogenin are associated with amyotrophic lateral sclerosis. Angiogenin has been shown to cleave transfer RNAs during stress to produce 'transfer-derived stress-induced RNAs'. Stress-induced tRNA cleavage is preserved from single-celled organisms to humans indicating it represents part of a highly conserved stress response. However, to date, the role of tRNA cleavage in amyotrophic lateral sclerosis remains to be fully elucidated. To this end, we performed small RNA sequencing on a human astrocytoma cell line to identify the complete repertoire of tRNA fragments generated by angiogenin. We found that only a specific subset of tRNAs is cleaved by angiogenin and identified 5'ValCAC transfer-derived stress-induced RNA to be secreted from neural cells. 5'ValCAC was quantified in spinal cord and serum from SOD1
Identifiants
pubmed: 33543130
doi: 10.1093/braincomms/fcaa138
pii: fcaa138
pmc: PMC7850272
doi:
Types de publication
Journal Article
Langues
eng
Pagination
fcaa138Informations de copyright
© The Author(s) (2020). Published by Oxford University Press on behalf of the Guarantors of Brain.
Références
Neurology. 2006 Nov 28;67(10):1833-6
pubmed: 17130418
J Neurosci. 2008 Dec 24;28(52):14056-61
pubmed: 19109488
Genome Biol. 2014;15(12):550
pubmed: 25516281
FEBS J. 2008 Apr;275(8):1925-36
pubmed: 18341587
Front Neurosci. 2012 Nov 19;6:167
pubmed: 23181008
Biochemistry. 1986 Jun 17;25(12):3527-32
pubmed: 2424496
Nucleic Acids Res. 2010 Nov;38(20):7248-59
pubmed: 20615901
Sci Rep. 2020 May 5;10(1):7516
pubmed: 32371908
Nat Genet. 2006 Apr;38(4):411-3
pubmed: 16501576
FEBS Lett. 2009 Jan 22;583(2):437-42
pubmed: 19114040
Neuropharmacology. 2018 May 1;133:503-511
pubmed: 29486168
J Neurol Neurosurg Psychiatry. 2014 Dec;85(12):1439-40
pubmed: 24876190
J Neurosci. 2012 Apr 11;32(15):5024-38
pubmed: 22496549
J Clin Invest. 2019 Apr 30;129(7):2946-2951
pubmed: 31039137
Algorithms Mol Biol. 2011 Nov 24;6:26
pubmed: 22115189
Sci Rep. 2016 Feb 11;6:20850
pubmed: 26865164
BMC Biol. 2014 Oct 01;12:78
pubmed: 25270025
Genome Res. 2017 Nov;27(11):1895-1903
pubmed: 28887402
EMBO J. 2014 Sep 17;33(18):2020-39
pubmed: 25063673
Mol Cell Biol. 2014 Jul;34(13):2450-63
pubmed: 24752898
Cell. 2016 Aug 11;166(4):894-906
pubmed: 27518564
Dis Model Mech. 2019 Aug 13;12(8):
pubmed: 31383794
J Neurol Sci. 1994 Jul;124 Suppl:96-107
pubmed: 7807156
J Biol Chem. 2012 Dec 14;287(51):42708-25
pubmed: 23086926
J Biol Chem. 1996 Apr 12;271(15):8983-90
pubmed: 8621544
J Neurol Neurosurg Psychiatry. 2011 Oct;82(10):1165-70
pubmed: 21622937
Nat Cell Biol. 2011 Apr;13(4):423-33
pubmed: 21423178
Nat Commun. 2019 Jan 10;10(1):118
pubmed: 30631057
J Biol Chem. 2010 Apr 2;285(14):10959-68
pubmed: 20129916
Nature. 2017 Dec 7;552(7683):57-62
pubmed: 29186115
RNA. 2015 Nov;21(11):1966-79
pubmed: 26392588
Mol Ther. 2013 Feb;21(2):368-79
pubmed: 23183536
Lancet. 2017 Nov 4;390(10107):2084-2098
pubmed: 28552366
Nucleic Acids Res. 2010 Apr;38(7):e98
pubmed: 20081203
J Biol Chem. 2005 Dec 30;280(52):42744-9
pubmed: 16272149
Nat Commun. 2012;3:1121
pubmed: 23047679
Amyotroph Lateral Scler Frontotemporal Degener. 2018 Aug;19(5-6):438-445
pubmed: 29221425
Bioanalysis. 2014 May;6(9):1215-26
pubmed: 24946922
Nucleic Acids Res. 2009 Jan;37(Database issue):D93-7
pubmed: 18984615
Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18201-6
pubmed: 25404306
Nat Genet. 2016 Sep;48(9):1043-8
pubmed: 27455348
Mol Cell. 2011 Aug 19;43(4):613-23
pubmed: 21855800
Trends Cell Biol. 2012 Mar;22(3):125-32
pubmed: 22260888
J Biol Chem. 2013 Aug 30;288(35):25266-74
pubmed: 23867462
Neuroscience. 2014 Sep 26;277:132-8
pubmed: 24699224
Neurobiol Dis. 2014 Nov;71:317-24
pubmed: 25134731
Genes Dev. 2010 Aug 1;24(15):1590-5
pubmed: 20679393
Sci Rep. 2015 Oct 08;5:14918
pubmed: 26446566
Ann Neurol. 2014 Feb;75(2):287-97
pubmed: 24382602
Mol Cell Oncol. 2015 Nov 23;3(2):e1079672
pubmed: 27308603
Brain. 2013 Nov;136(Pt 11):3305-32
pubmed: 24065725
Methods. 2001 Dec;25(4):402-8
pubmed: 11846609
BMC Res Notes. 2010 Nov 10;3:294
pubmed: 21067583
Ann Neurol. 2007 Dec;62(6):609-17
pubmed: 17886298
PLoS One. 2015 Aug 19;10(8):e0135570
pubmed: 26288094
J Extracell Vesicles. 2014 Nov 13;3:24722
pubmed: 25398455
Elife. 2019 Aug 22;8:
pubmed: 31436530
Glia. 2007 Jan 15;55(2):165-77
pubmed: 17078026
Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E8987-E8995
pubmed: 29073095
Cell. 2018 May 17;173(5):1204-1216.e26
pubmed: 29628141
J Neurochem. 2011 Feb;116(3):334-41
pubmed: 21091473
Alzheimer Dis Assoc Disord. 2019 Apr-Jun;33(2):163-165
pubmed: 30188356
Ann Neurol. 2011 Dec;70(6):964-73
pubmed: 22190368
J Cell Biol. 2009 Apr 6;185(1):35-42
pubmed: 19332886
Cell Death Differ. 2009 Sep;16(9):1238-47
pubmed: 19444281