Functional expression and localisation of HOPS/TMUB1 in mouse lens.
HOPS/TMUB1
UBL modifier
differentiation
lens
proliferation
Journal
Bioscience reports
ISSN: 1573-4935
Titre abrégé: Biosci Rep
Pays: England
ID NLM: 8102797
Informations de publication
Date de publication:
26 02 2021
26 02 2021
Historique:
received:
23
11
2020
revised:
03
02
2021
accepted:
04
02
2021
pubmed:
6
2
2021
medline:
16
12
2021
entrez:
5
2
2021
Statut:
ppublish
Résumé
Transparency represents the functional phenotype of eye lens. A number of defined steps including quiescence, proliferation, migration and cell differentiation culminates in cell elongation and organelle degradation, allowing the light to reach the retina. HOPS (Hepatocyte Odd Protein Shuttling)/TMUB1 (Trans Membrane Ubiquitin-like containing protein 1) is a nucleo-cytoplasmic shuttling protein, highly expressed both in vivo and in vitro proliferating systems, bearing a ubiquitin-like domain. The present study shows HOPS expression during the phases of lens cell proliferation and fiber differentiation, and its localisation in lens compartments. In lens, HOPS localises mainly in the nucleus of central epithelial cells. During mitosis, HOPS/TMUB1 shuttles to the cytoplasm and returns to the nucleus at the end of mitosis. The differentiating cells share distinct HOPS/TMUB1 localisation in transitional zone depending on the differentiation phases. HOPS/TMUB1 is observed in lens cortex and nucleus. Here, it is attached to fibers, having a structural function with crystallin proteins, probably acting in the ubiquitin-proteasome system.
Identifiants
pubmed: 33543240
pii: 227785
doi: 10.1042/BSR20203998
pmc: PMC7881158
pii:
doi:
Substances chimiques
HOPS protein, mouse
0
Intracellular Signaling Peptides and Proteins
0
Membrane Proteins
0
Vimentin
0
Epidermal Growth Factor
62229-50-9
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2021 The Author(s).
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