Prevalence of Metastatic Lateral Lymph Nodes in Asian Patients with Lateral Lymph Node Dissection for Rectal Cancer: A Meta-analysis.
Journal
World journal of surgery
ISSN: 1432-2323
Titre abrégé: World J Surg
Pays: United States
ID NLM: 7704052
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
accepted:
05
01
2021
pubmed:
6
2
2021
medline:
9
7
2021
entrez:
5
2
2021
Statut:
ppublish
Résumé
Rectal cancers occupy the eighth position worldwide for new cases and deaths for both men and women. These cancers have a high tendency to form metastases in the mesorectum but also in the lateral lymph nodes. The therapeutic approach for the involved lateral lymph nodes remains controversial. We performed a systematic review and meta-analysis to assess the prevalence of metastatic lateral lymph nodes in patients with lateral lymph node dissection (LLND) for rectal cancer, which seems to be a fundamental and necessary criterion to discuss any possible indications for LLND. Data sources-study selection-data extraction and synthesis-main outcome and measures. We searched MEDLINE, EMBASE and COCHRANE from November 1, 2018, to November 19, 2018, for studies reporting the presence of metastatic lateral lymph nodes (iliac, obturator and middle sacral nodes) among patients undergoing rectal surgery with LLND. Pooled prevalence values were obtained by random effects models, and the robustness was tested by leave-one-out sensitivity analyses. Heterogeneity was assessed using the Q-test, quantified based on the I2 value and explored by subgroup analyses. Our final analysis included 31 studies from Asian countries, comprising 7599 patients. The pooled prevalence of metastatic lateral lymph nodes was 17.3% (95% CI: 14.6-20.5). The inter-study variability (heterogeneity) was high (I The pooled prevalence of metastatic lateral lymph nodes was 17.3% among patients who underwent rectal surgery with LLND in Asian countries. Further studies are necessary to determine whether this finding could impact the therapeutic strategy (total mesorectal excision with LLND versus total mesorectal excision with neoadjuvant radiochemotherapy).
Identifiants
pubmed: 33543333
doi: 10.1007/s00268-021-05956-1
pii: 10.1007/s00268-021-05956-1
pmc: PMC8026473
doi:
Types de publication
Journal Article
Meta-Analysis
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1537-1547Références
Funahashi K, Koike J, Shimada M, Okamoto K, Goto T, Teramoto T (2006) A preliminary study of the draining lymph node basin in advanced lower rectal cancer using a radioactive tracer. Dis Colon Rectum 49(10 Suppl):S53-58
doi: 10.1007/s10350-006-0659-2
Manfredi S, Benhamiche AM, Meny B, Cheynel N, Rat P, Faivre J (2001) Population-based study of factors influencing occurrence and prognosis of local recurrence after surgery for rectal cancer. Br J Surg 88(9):1221–1227
doi: 10.1046/j.0007-1323.2001.01861.x
van de Velde CJ, Boelens PG, Borras JM et al (2014) EURECCA colorectal: multidisciplinary management: European consensus conference colon and rectum. Eur J Cancer 50(1):1-e1
pubmed: 24183379
Watanabe T, Muro K, Ajioka Y et al (2018) Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2016 for the treatment of colorectal cancer. Int J Clin Oncol 23(1):1–34
doi: 10.1007/s10147-017-1101-6
Fujita S, Akasu T, Mizusawa J et al (2012) Postoperative morbidity and mortality after mesorectal excision with and without lateral lymph node dissection for clinical stage II or stage III lower rectal cancer (JCOG0212): results from a multicentre, randomised controlled, non-inferiority trial. Lancet Oncol 13(6):616–621
doi: 10.1016/S1470-2045(12)70158-4
Masaki T, Matsuoka H, Kobayashi T et al (2010) Quality assurance of pelvic autonomic nerve-preserving surgery for advanced lower rectal cancer–preliminary results of a randomized controlled trial. Langenbecks Arch Surg 395(6):607–613
doi: 10.1007/s00423-010-0655-9
DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7(3):177–188
doi: 10.1016/0197-2456(86)90046-2
Viechtbauer W, Lopez-Lopez JA, Sanchez-Meca J, Marin-Martinez F (2015) A comparison of procedures to test for moderators in mixed-effects meta-regression models. Psychol Methods 20(3):360–374
doi: 10.1037/met0000023
Hara M, Hirai T, Nakanishi H et al (2007) Isolated tumor cell in lateral lymph node has no influences on the prognosis of rectal cancer patients. Int J Colorectal Dis 22(8):911–917
doi: 10.1007/s00384-007-0280-4
Ishibe A, Ota M, Watanabe J et al (2016) Prediction of lateral pelvic lymph-node metastasis in low rectal cancer by magnetic resonance imaging. World J Surg 40(4):995–1001
doi: 10.1007/s00268-015-3299-7
Kanemitsu Y, Komori K, Shida D et al (2017) Potential impact of lateral lymph node dissection (LLND) for low rectal cancer on prognoses and local control: a comparison of 2 high-volume centers in Japan that employ different policies concerning LLND. Surgery 162(2):303–314
doi: 10.1016/j.surg.2017.02.005
Ishida H, Hatano S, Ishiguro T, Kumamoto K, Ishibashi K, Haga N (2012) Prediction of lateral lymph node metastasis in lower rectal cancer: analysis of paraffin-embedded sections. Jpn J Clin Oncol 42(6):485–490
doi: 10.1093/jjco/hys041
Kagawa H, Kinugasa Y, Shiomi A et al (2015) Robotic-assisted lateral lymph node dissection for lower rectal cancer: short-term outcomes in 50 consecutive patients. Surg Endosc 29(4):995–1000
doi: 10.1007/s00464-014-3760-y
Matsuoka H, Nakamura A, Masaki T et al (2007) Optimal diagnostic criteria for lateral pelvic lymph node metastasis in rectal carcinoma. Anticancer Res 27(5B):3529–3533
pubmed: 17972513
Miyake Y, Mizushima T, Hata T et al (2017) Inspection of perirectal lymph nodes by one-step nucleic acid amplification predicts lateral lymph node metastasis in advanced rectal cancer. Ann Surg Oncol 24(13):3850–3856
doi: 10.1245/s10434-017-6069-y
Min BS, Kim JS, Kim NK et al (2009) Extended lymph node dissection for rectal cancer with radiologically diagnosed extramesenteric lymph node metastasis. Ann Surg Oncol 16(12):3271–3278
doi: 10.1245/s10434-009-0692-1
Sato T, Ozawa H, Hatate K et al (2011) A Phase II trial of neoadjuvant preoperative chemoradiotherapy with S-1 plus irinotecan and radiation in patients with locally advanced rectal cancer: clinical feasibility and response rate. Int J Radiat Oncol Biol Phys 79(3):677–683
doi: 10.1016/j.ijrobp.2009.11.007
Sato H, Maeda K, Maruta M (2011) Prognostic significance of lateral lymph node dissection in node positive low rectal carcinoma. Int J Colorectal Dis 26(7):881–889
doi: 10.1007/s00384-011-1170-3
Shimoyama M, Yamazaki T, Suda T, Hatakeyama K (2003) Prognostic significance of lateral lymph node micrometastases in lower rectal cancer: an immunohistochemical study with CAM5.2. Dis Colon Rectum 46(3):333–339
doi: 10.1007/s10350-004-6552-y
Yokoyama S, Takifuji K, Hotta T et al (2014) Survival benefit of lateral lymph node dissection according to the region of involvement and the number of lateral lymph nodes involved. Surg Today 44(6):1097–1103
doi: 10.1007/s00595-013-0815-y
Komori K, Kanemitsu Y, Kimura K et al (2013) Detailed stratification of TNM stage III rectal cancer based on the presence/absence of extracapsular invasion of the metastatic lymph nodes. Dis Colon Rectum 56(6):726–732
doi: 10.1097/DCR.0b013e318286c518
Masaki T, Takayama M, Matsuoka H et al (2008) Intraoperative radiotherapy for oncological and function-preserving surgery in patients with advanced lower rectal cancer. Langenbecks Arch Surg 393(2):173–180
doi: 10.1007/s00423-007-0260-8
Wu ZY, Wan J, Li JH et al (2007) Prognostic value of lateral lymph node metastasis for advanced low rectal cancer. World J Gastroenterol 13(45):6048–6052
doi: 10.3748/wjg.v13.45.6048
Hida J, Yasutomi M, Fujimoto K, Maruyama T, Okuno K, Shindo K (1997) Does lateral lymph node dissection improve survival in rectal carcinoma? examination of node metastases by the clearing method. J Am Coll Surg 184(5):475–480
pubmed: 9145067
Ueno M, Oya M, Azekura K, Yamaguchi T, Muto T (2005) Incidence and prognostic significance of lateral lymph node metastasis in patients with advanced low rectal cancer. Br J Surg 92(6):756–763
doi: 10.1002/bjs.4975
Ueno H, Mochizuki H, Hashiguchi Y et al (2007) Potential prognostic benefit of lateral pelvic node dissection for rectal cancer located below the peritoneal reflection. Ann Surg 245(1):80–87
doi: 10.1097/01.sla.0000225359.72553.8c
Steup WH, Hojo K, Moriya Y et al (1994) An analysis on the effect of blood transfusion on recurrence and survival in patients undergoing extended lymphadenectomy for colorectal cancer. Hepatogastroenterology 41(3):253–259
pubmed: 7959548
Mori T, Takahashi K, Yasuno M (1998) Radical resection with autonomic nerve preservation and lymph node dissection techniques in lower rectal cancer surgery and its results: the impact of lateral lymph node dissection. Langenbecks Arch Surg 383(6):409–415
doi: 10.1007/s004230050153
Tan KY, Yamamoto S, Fujita S, Akasu T, Moriya Y (2010) Improving prediction of lateral node spread in low rectal cancers–multivariate analysis of clinicopathological factors in 1046 cases. Langenbecks Arch Surg 395(5):545–549
doi: 10.1007/s00423-010-0642-1
Nagasaki T, Akiyoshi T, Fujimoto Y et al (2017) Preoperative chemoradiotherapy might improve the prognosis of patients with locally advanced low rectal cancer and lateral pelvic lymph node metastases. World J Surg 41(3):876–883
doi: 10.1007/s00268-016-3748-y
Yamaoka Y, Kinugasa Y, Shiomi A et al (2017) Preoperative chemoradiotherapy changes the size criterion for predicting lateral lymph node metastasis in lower rectal cancer. Int J Colorectal Dis 32(11):1631–1637
doi: 10.1007/s00384-017-2873-x
Numata M, Yamaguchi T, Kinugasa Y et al (2017) Index of estimated benefit from lateral lymph node dissection for middle and lower rectal cancer. Anticancer Res 37(5):2549–2555
doi: 10.21873/anticanres.11598
Yamaguchi T, Kinugasa Y, Shiomi A, Tomioka H, Kagawa H, Yamakawa Y (2016) Robotic-assisted vs. conventional laparoscopic surgery for rectal cancer: short-term outcomes at a single center. Surg Today 46(8):957–962
doi: 10.1007/s00595-015-1266-4
Yu YY, Wang C, Xu D, Shen XG, Ding SQ, Zhou ZG (2011) Mesorectal and lateral node metastasis and micrometastasis in lower rectal cancer. Hepatogastroenterology 58(107–108):745–748
pubmed: 21830382
Kobayashi H, Mochizuki H, Kato T et al (2009) Outcomes of surgery alone for lower rectal cancer with and without pelvic sidewall dissection. Dis Colon Rectum 52(4):567–576
doi: 10.1007/DCR.0b013e3181a1d994
Yano H, Saito Y, Takeshita E, Miyake O, Ishizuka N (2007) Prediction of lateral pelvic node involvement in low rectal cancer by conventional computed tomography. Br J Surg 94(8):1014–1019
doi: 10.1002/bjs.5665
Kinugasa T, Akagi Y, Ochi T et al (2013) Lateral lymph-node dissection for rectal cancer: meta-analysis of all 944 cases undergoing surgery during 1975–2004. Anticancer Res 33(7):2921–2927
pubmed: 23780981
Yamaguchi T, Kinugasa Y, Shiomi A, Tomioka H, Kagawa H (2016) Robotic-assisted laparoscopic versus open lateral lymph node dissection for advanced lower rectal cancer. Surg Endosc 30(2):721–728
doi: 10.1007/s00464-015-4266-y
Steup WH, Moriya Y, van de Velde CJ (2002) Patterns of lymphatic spread in rectal cancer. a topographical analysis on lymph node metastases. Eur J Cancer. 38(7):911–918
doi: 10.1016/S0959-8049(02)00046-1
Du R, Zhou J, Li D, Zhang Q, Liu J, Ma C, et al. (2020) Postoperative morbidity and mortality after mesorectal excision with laparoscopic versus conventional open lateral lymph node dissection for advanced rectal cancer: a meta-analysis. Asian J Surg [Internet]. 11 août 2020; Disponible sur: http://www.sciencedirect.com/science/article/pii/S1015958420301950
Yang X, Yang S, Hu T, Gu C, Wei M, Deng X et al (2020) What is the role of lateral lymph node dissection in rectal cancer patients with clinically suspected lateral lymph node metastasis after preoperative chemoradiotherapy? a meta-analysis and systematic review. Cancer Med 9(13):4477–4489
doi: 10.1002/cam4.2643
Gao X, Wang C, Yu Y, Yang L, Zhou Z (2020) Lateral lymph node dissection reduces local recurrence of locally advanced lower rectal cancer in the absence of preoperative neoadjuvant chemoradiotherapy: a systematic review and meta-analysis. Disponible sur: https://europepmc.org/article/ppr/ppr216100