Widespread corticopetal projections from the oval paracentral nucleus of the intralaminar thalamic nuclei conveying orofacial proprioception in rats.
Cerebral cortex
Deep sensation
Muscle sensation
OPC
Thalamus
Journal
Brain structure & function
ISSN: 1863-2661
Titre abrégé: Brain Struct Funct
Pays: Germany
ID NLM: 101282001
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
received:
22
07
2020
accepted:
21
01
2021
pubmed:
6
2
2021
medline:
1
12
2021
entrez:
5
2
2021
Statut:
ppublish
Résumé
The oval paracentral nucleus (OPC) was initially isolated from the paracentral nucleus (PC) within the intralaminar thalamic nuclei in rats. We have recently shown that the rat OPC receives proprioceptive inputs from jaw-closing muscle spindles (JCMSs). However, it remains unknown which cortical areas receive thalamic inputs from the OPC, and whether the cortical areas receiving the OPC inputs are distinct from those receiving inputs from the other intralaminar nuclei and sensory thalamic nuclei. To address this issue, we injected an anterograde tracer, biotinylated dextranamine (BDA), into the OPC, which was electrophysiologically identified by recording of proprioceptive inputs from the JCMSs. Many BDA-labeled axonal fibers and terminals from the OPC were ipsilaterally observed in the rostral and rostroventral regions of the primary somatosensory cortex (S1), the rostral region of the secondary somatosensory cortex (S2), and the most rostrocaudal levels of the granular insular cortex (GI). In contrast, a BDA injection into the caudal PC, which was located slightly rostral to the OPC, resulted in ipsilateral labeling of axonal fibers and terminals in the rostrolateral region of the medial agranular cortex and the rostromedial region of the lateral agranular cortex. Furthermore, injections of a retrograde tracer, Fluorogold, into these S1, S2, and GI regions, resulted in preferential labeling of neurons in the ipsilateral OPC among the intralaminar and sensory thalamic nuclei. These findings reveal that the rat OPC has widespread, but strong corticopetal projections, indicating that there exist divergent corticopetal pathways from the intralaminar thalamic nucleus, which process JCMS proprioceptive sensation.
Identifiants
pubmed: 33543335
doi: 10.1007/s00429-021-02228-5
pii: 10.1007/s00429-021-02228-5
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1115-1133Subventions
Organisme : Grants-in-Aid for Scientific Research of the Japan Society for the Promotion of Science
ID : 18K19641
Organisme : Grants-in-Aid for Scientific Research of the Japan Society for the Promotion of Science
ID : 18KK0259
Organisme : Grants-in-Aid for Scientific Research of the Japan Society for the Promotion of Science
ID : 17K11608
Organisme : Grants-in-Aid for Scientific Research of the Japan Society for the Promotion of Science
ID : 20K09888
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