Primary Progressive Aphasia: Toward a Pathophysiological Synthesis.
Alzheimer’s disease
Frontotemporal dementia
Logopenic aphasia
Physiology
Primary progressive aphasia
Progressive nonfluent aphasia
Semantic dementia
Journal
Current neurology and neuroscience reports
ISSN: 1534-6293
Titre abrégé: Curr Neurol Neurosci Rep
Pays: United States
ID NLM: 100931790
Informations de publication
Date de publication:
04 02 2021
04 02 2021
Historique:
accepted:
13
01
2021
entrez:
5
2
2021
pubmed:
6
2
2021
medline:
28
4
2021
Statut:
epublish
Résumé
The term primary progressive aphasia (PPA) refers to a diverse group of dementias that present with prominent and early problems with speech and language. They present considerable challenges to clinicians and researchers. Here, we review critical issues around diagnosis of the three major PPA variants (semantic variant PPA, nonfluent/agrammatic variant PPA, logopenic variant PPA), as well as considering 'fragmentary' syndromes. We next consider issues around assessing disease stage, before discussing physiological phenotyping of proteinopathies across the PPA spectrum. We also review evidence for core central auditory impairments in PPA, outline critical challenges associated with treatment, discuss pathophysiological features of each major PPA variant, and conclude with thoughts on key challenges that remain to be addressed. New findings elucidating the pathophysiology of PPA represent a major step forward in our understanding of these diseases, with implications for diagnosis, care, management, and therapies.
Identifiants
pubmed: 33543347
doi: 10.1007/s11910-021-01097-z
pii: 10.1007/s11910-021-01097-z
pmc: PMC7861583
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
7Subventions
Organisme : Department of Health
ID : DRF-2015-08-182
Pays : United Kingdom
Organisme : RNID
ID : PA23
Pays : United Kingdom
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