ADAM Proteins
/ deficiency
Animals
Brain Neoplasms
/ metabolism
Cell Proliferation
Cells, Cultured
Glioblastoma
/ metabolism
Humans
Membrane Proteins
/ deficiency
Mice
Mice, Inbred C57BL
Mice, Knockout
Neoplasms, Experimental
/ metabolism
Neovascularization, Pathologic
/ metabolism
Osteopontin
/ metabolism
ADAM8
GBM cell lines
angiogenesis
glioblastoma
macrophages
osteopontin
tumor microenvironment
Journal
Biological chemistry
ISSN: 1437-4315
Titre abrégé: Biol Chem
Pays: Germany
ID NLM: 9700112
Informations de publication
Date de publication:
27 01 2021
27 01 2021
Historique:
received:
12
05
2020
accepted:
18
08
2020
entrez:
5
2
2021
pubmed:
6
2
2021
medline:
22
7
2021
Statut:
epublish
Résumé
Glioblastoma multiforme (GBM) is the most aggressive type of brain cancer with a median survival of only 15 months. To complement standard treatments including surgery, radiation and chemotherapy, it is essential to understand the contribution of the GBM tumor microenvironment. Brain macrophages and microglia particularly contribute to tumor angiogenesis, a major hallmark of GBM.
Identifiants
pubmed: 33544472
pii: hsz-2020-0184
doi: 10.1515/hsz-2020-0184
doi:
Substances chimiques
Membrane Proteins
0
Osteopontin
106441-73-0
ADAM Proteins
EC 3.4.24.-
ADAM8 protein, human
EC 3.4.24.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
195-206Informations de copyright
© 2020 Yu Li et al., published by De Gruyter, Berlin/Boston.
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