Hepatic Steatosis is Negatively Associated with Bone Mineral Density in Children.
Absorptiometry, Photon
Adolescent
Alanine Transaminase
/ blood
Bone Density
/ physiology
Child
Female
Humans
Liver
/ diagnostic imaging
Magnetic Resonance Imaging
Male
Non-alcoholic Fatty Liver Disease
/ physiopathology
Sampling Studies
Vitamin D
/ analogs & derivatives
gamma-Glutamyltransferase
/ blood
MRI-PDFF
NAFLD
osteopenia
osteoporosis
pediatric
vitamin D
Journal
The Journal of pediatrics
ISSN: 1097-6833
Titre abrégé: J Pediatr
Pays: United States
ID NLM: 0375410
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
16
11
2020
revised:
12
01
2021
accepted:
27
01
2021
pubmed:
6
2
2021
medline:
24
8
2021
entrez:
5
2
2021
Statut:
ppublish
Résumé
To evaluate the relationship between hepatic steatosis and bone mineral density (BMD) in children. In addition, to assess 25-hydroxyvitamin D levels in the relationship between hepatic steatosis and BMD. A community-based sample of 235 children was assessed for hepatic steatosis, BMD, and serum 25-hydroxyvitamin D. Hepatic steatosis was measured by liver magnetic resonance imaging proton density fat fraction (MRI-PDFF). BMD was measured by whole-body dual-energy x-ray absorptiometry. The mean age of the study population was 12.5 years (SD 2.5 years). Liver MRI-PDFF ranged from 1.1% to 40.1% with a mean of 9.3% (SD 8.5%). Across this broad spectrum of hepatic fat content, there was a significant negative relationship between liver MRI-PDFF and BMD z score (R = -0.421, P < .001). Across the states of sufficiency, insufficiency, and deficiency, there was a significant negative association between 25-hydroxyvitamin D and liver MRI-PDFF (P < .05); however, there was no significant association between vitamin D status and BMD z score (P = .94). Finally, children with clinically low BMD z scores were found to have higher alanine aminotransferase (P < .05) and gamma-glutamyl transferase (P < .05) levels compared with children with normal BMD z scores. Across the full range of liver MRI-PDFF, there was a strong negative relationship between hepatic steatosis and BMD z score. Given the prevalence of nonalcoholic fatty liver disease and the critical importance of childhood bone mineralization in protecting against osteoporosis, clinicians should prioritize supporting bone development in children with nonalcoholic fatty liver disease.
Identifiants
pubmed: 33545191
pii: S0022-3476(21)00098-6
doi: 10.1016/j.jpeds.2021.01.064
pmc: PMC8154638
mid: NIHMS1669606
pii:
doi:
Substances chimiques
Vitamin D
1406-16-2
25-hydroxyvitamin D
A288AR3C9H
gamma-Glutamyltransferase
EC 2.3.2.2
Alanine Transaminase
EC 2.6.1.2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
105-111.e3Subventions
Organisme : NCATS NIH HHS
ID : TL1 TR001443
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000100
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001442
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Références
Clin Endocrinol (Oxf). 2011 Aug;75(2):189-95
pubmed: 21521307
J Clin Endocrinol Metab. 2011 Jul;96(7):1911-30
pubmed: 21646368
J Pediatr Gastroenterol Nutr. 2017 Feb;64(2):319-334
pubmed: 28107283
J Korean Med Sci. 2015 Dec;30(12):1821-7
pubmed: 26713058
J Pediatr Gastroenterol Nutr. 2019 Feb;68(2):182-189
pubmed: 30640271
Aliment Pharmacol Ther. 2012 Jan;35(2):248-54
pubmed: 22111971
Magn Reson Imaging. 2008 Apr;26(3):347-59
pubmed: 18093781
J Bone Miner Res. 2011 Aug;26(8):1729-39
pubmed: 21520276
Radiology. 2011 Mar;258(3):749-59
pubmed: 21212366
Pediatr Rheumatol Online J. 2020 Feb 24;18(1):20
pubmed: 32093703
Osteoporos Int. 2014 Dec;25(12):2673-84
pubmed: 25138259
Nutrients. 2017 Sep 14;9(9):
pubmed: 28906453
Clin Radiol. 2017 May;72(5):425.e9-425.e14
pubmed: 28063601
Hepatology. 2015 Jun;61(6):1887-95
pubmed: 25529941
PLoS One. 2014 Nov 24;9(11):e112569
pubmed: 25419656
Obes Rev. 2017 May;18(5):526-546
pubmed: 28273691
J Clin Endocrinol Metab. 2008 Jun;93(6):2281-6
pubmed: 18381577
Trials. 2017 Aug 10;18(1):372
pubmed: 28793919
World J Gastroenterol. 2013 Jul 7;19(25):4007-14
pubmed: 23840146
J Am Coll Nutr. 2001 Apr;20(2 Suppl):168S-185S
pubmed: 11349940
J Magn Reson Imaging. 2008 Jul;28(1):246-51
pubmed: 18581393
Int J Environ Res Public Health. 2020 Apr 22;17(8):
pubmed: 32331270
Diabetes Metab Syndr. 2018 Jul;12(4):513-517
pubmed: 29588137
J Pediatr. 2018 Jul;198:76-83.e2
pubmed: 29661561
Science. 1999 Apr 2;284(5411):143-7
pubmed: 10102814
Lancet. 1991 Aug 10;338(8763):355-8
pubmed: 1677708
JBMR Plus. 2017 Aug;1(1):31-35
pubmed: 29124252
Pediatrics. 2006 Oct;118(4):1388-93
pubmed: 17015527
J Clin Densitom. 2014 Jan-Mar;17(1):163-9
pubmed: 23522982
Osteoporos Int. 2007 May;18(5):641-7
pubmed: 17139464
J Bone Miner Res. 2007 Mar;22(3):465-75
pubmed: 17144789
Pediatr Res. 2018 Nov;84(5):684-688
pubmed: 30120405
J Gerontol A Biol Sci Med Sci. 2013 Oct;68(10):1243-51
pubmed: 23902935
Arch Osteoporos. 2018 Mar 20;13(1):31
pubmed: 29556801
Aliment Pharmacol Ther. 2013 Aug;38(3):246-54
pubmed: 23786213
Osteoporos Int. 2016 Jul;27(7):2147-2179
pubmed: 27125514
Gastroenterology. 2017 Sep;153(3):753-761
pubmed: 28624576
J Bone Miner Res. 2014 Nov;29(11):2520-6
pubmed: 24771492
J Clin Endocrinol Metab. 2007 Jun;92(6):2087-99
pubmed: 17311856
Aliment Pharmacol Ther. 2013 Nov;38(10):1267-77
pubmed: 24117728
NMR Biomed. 2011 Aug;24(7):784-90
pubmed: 21834002
J Clin Densitom. 2008 Jan-Mar;11(1):43-58
pubmed: 18442752
Radiology. 2009 Apr;251(1):67-76
pubmed: 19221054
JAMA Pediatr. 2016 Oct 3;170(10):e161971
pubmed: 27478956