Epigenetic reprogramming during prostate cancer progression: A perspective from development.
Cell fate
Cell plasticity
Differentiation
Epigenetics
Prostate cancer
Journal
Seminars in cancer biology
ISSN: 1096-3650
Titre abrégé: Semin Cancer Biol
Pays: England
ID NLM: 9010218
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
02
12
2020
revised:
27
01
2021
accepted:
27
01
2021
pubmed:
6
2
2021
medline:
15
6
2022
entrez:
5
2
2021
Statut:
ppublish
Résumé
Conrad Waddington's theory of epigenetic landscape epitomize the process of cell fate and cellular decision-making during development. Wherein the epigenetic code maintains patterns of gene expression in pluripotent and differentiated cellular states during embryonic development and differentiation. Over the years disruption or reprogramming of the epigenetic landscape has been extensively studied in the course of cancer progression. Cellular dedifferentiation being a key hallmark of cancer allow us to take cues from the biological processes involving epigenetic reprogramming in development such as the cellular differentiation and morphogenesis. Here, we discuss the role of epigenetic landscape and its modifiers in cell-fate determination, differentiation and prostate cancer progression. Lately, the emergence of RNA-modifications has also furthered our understanding of epigenetics in cancer. The overview of the epigenetic code regulating androgen signalling, and progression to aggressive neuroendocrine stage of PCa reinforces its gene regulatory functions during the development of prostate gland as well as cancer progression. Additionally, we also highlight the clinical implications of cancer cell epigenome, and discuss the recent advancements in the therapeutic strategies targeting the advanced stage disease.
Identifiants
pubmed: 33545340
pii: S1044-579X(21)00023-7
doi: 10.1016/j.semcancer.2021.01.009
pmc: PMC7612861
mid: EMS131904
pii:
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
136-151Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : DBT-Wellcome Trust India Alliance
ID : IA/S/19/2/504659
Pays : India
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Références
Exp Mol Med. 2017 Apr 28;49(4):e324
pubmed: 28450737
Cancer Res. 2016 May 1;76(9):2637-51
pubmed: 26984757
Cell. 2007 Feb 23;128(4):693-705
pubmed: 17320507
Nature. 2011 Jul 13;476(7359):228-31
pubmed: 21753754
Nat Rev Genet. 2014 Feb;15(2):93-106
pubmed: 24366184
Trends Biochem Sci. 2013 Apr;38(4):204-9
pubmed: 23337769
Endocr Relat Cancer. 2019 Dec;26(12):R673-R688
pubmed: 31627186
Phys Biol. 2019 Sep 06;16(6):066004
pubmed: 31342918
Cancer Res. 1987 Oct 15;47(20):5274-6
pubmed: 2443238
Nat Commun. 2015 Sep 25;6:8219
pubmed: 26404510
Nat Rev Genet. 2009 May;10(5):295-304
pubmed: 19308066
Genome Res. 2012 May;22(5):837-49
pubmed: 22391556
Nano Lett. 2020 Oct 14;20(10):7028-7035
pubmed: 32857520
Cell Res. 2009 Mar;19(3):282-95
pubmed: 19188930
Asian J Androl. 2010 Mar;12(2):171-9
pubmed: 19935671
Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):E3395-404
pubmed: 23184966
Epigenomics. 2020 Aug;12(15):1317-1332
pubmed: 32867540
Genome Res. 2019 Sep;29(9):1521-1532
pubmed: 31315906
NAR Cancer. 2020 Sep;2(3):zcaa018
pubmed: 32885168
Curr Biol. 2002 Apr 2;12(7):R245-7
pubmed: 11937040
Cytogenet Cell Genet. 1975;14(1):9-25
pubmed: 1093816
Expert Opin Ther Pat. 2015 Feb;25(2):135-44
pubmed: 25468267
Prostate. 2011 Nov;71(15):1621-30
pubmed: 21432864
World J Oncol. 2019 Apr;10(2):63-89
pubmed: 31068988
Clin Epigenetics. 2018 Oct 29;10(1):132
pubmed: 30373654
Trends Cancer. 2020 May;6(5):392-406
pubmed: 32348735
Biochem Biophys Res Commun. 2007 Feb 23;353(4):973-7
pubmed: 17207460
Urology. 2008 Jan;71(1):161-7
pubmed: 18242387
Science. 2001 Aug 10;293(5532):1074-80
pubmed: 11498575
PLoS One. 2017 May 3;12(5):e0177198
pubmed: 28467474
Clin Cancer Res. 2005 May 15;11(10):3604-8
pubmed: 15897554
Trends Genet. 2019 Nov;35(11):840-851
pubmed: 31623872
Cancer Res. 2014 Mar 15;74(6):1870-1880
pubmed: 24480624
Cell Rep. 2018 Sep 18;24(12):3353-3366.e5
pubmed: 30232014
Cancer Res. 2016 Jul 15;76(14):4192-204
pubmed: 27216188
Cancer Treat Rev. 2019 Jun;76:1-9
pubmed: 30913454
Science. 2017 Jan 6;355(6320):78-83
pubmed: 28059767
Int J Oncol. 2009 Jul;35(1):87-96
pubmed: 19513555
Trends Immunol. 2020 Aug;41(8):676-691
pubmed: 32622854
Cell. 2004 Dec 29;119(7):941-53
pubmed: 15620353
Prostate. 2019 Oct;79(14):1705-1714
pubmed: 31433512
Theranostics. 2020 Jan 1;10(1):353-370
pubmed: 31903125
Eur J Cancer. 2019 Nov;121:7-18
pubmed: 31525487
Nat Genet. 2005 Aug;37(8):853-62
pubmed: 16007088
Cancer Cell. 2009 May 5;15(5):416-28
pubmed: 19411070
J Cell Mol Med. 2018 Mar;22(3):1909-1922
pubmed: 29327812
J Biol Chem. 2009 Apr 24;284(17):11194-204
pubmed: 19244236
World J Urol. 2019 Apr;37(4):709-718
pubmed: 30069579
Cell Death Discov. 2019 Sep 30;5:139
pubmed: 31583122
J Clin Invest. 2014 Jan;124(1):30-9
pubmed: 24382387
Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):7414-7419
pubmed: 28652331
BMC Urol. 2012 Mar 13;12:5
pubmed: 22413846
Nat Genet. 1998 Jun;19(2):187-91
pubmed: 9620779
Science. 2002 Sep 13;297(5588):1833-7
pubmed: 12193640
Cancer Res. 2006 Dec 1;66(23):11341-7
pubmed: 17145880
Cancer Cell. 2016 Oct 10;30(4):563-577
pubmed: 27728805
Nat Rev Mol Cell Biol. 2019 Oct;20(10):590-607
pubmed: 31399642
Cancer Res. 2007 Jun 1;67(11):5097-102
pubmed: 17545586
Prostate. 2017 Feb;77(3):299-308
pubmed: 27800642
Nat Commun. 2020 Jan 20;11(1):384
pubmed: 31959826
Nat Genet. 2015 Jan;47(1):22-30
pubmed: 25485837
Nat Protoc. 2013 Jan;8(1):176-89
pubmed: 23288318
Circ Res. 2014 Jul 7;115(2):311-24
pubmed: 24989490
Nature. 1996 Jan 11;379(6561):131-7
pubmed: 8538762
Oncogene. 2014 Oct 9;33(41):4924-31
pubmed: 24141771
J Biol Chem. 2019 Jun 21;294(25):9911-9923
pubmed: 31085587
Prostate. 2010 Jun 15;70(9):982-92
pubmed: 20166136
Nat Cell Biol. 2006 May;8(5):532-8
pubmed: 16570078
Nature. 2007 Aug 2;448(7153):553-60
pubmed: 17603471
Clin Epigenetics. 2020 Mar 18;12(1):48
pubmed: 32188493
Oncotarget. 2013 Dec;4(12):2419-29
pubmed: 24293458
Oncotarget. 2017 Nov 6;8(70):114845-114855
pubmed: 29383125
BJU Int. 2012 Jul;110(1):56-62
pubmed: 22077694
Cell Signal. 2018 Nov;51:243-256
pubmed: 30121333
Nat Genet. 2003 Jun;34(2):187-92
pubmed: 12740577
Genes (Basel). 2019 Oct 04;10(10):
pubmed: 31590287
Nat Genet. 2020 Aug;52(8):778-789
pubmed: 32661416
Mol Cell Endocrinol. 2018 Feb 15;462(Pt A):41-55
pubmed: 28870782
Cancer Res. 1998 Dec 1;58(23):5310-4
pubmed: 9850055
J Cell Biol. 1994 Dec;127(6 Pt 2):2021-36
pubmed: 7806579
Onco Targets Ther. 2019 Nov 05;12:9143-9152
pubmed: 31806999
Am J Pathol. 2003 Sep;163(3):923-33
pubmed: 12937133
Dev Biol. 2014 Dec 15;396(2):237-45
pubmed: 25446526
Nature. 2002 Oct 10;419(6907):624-9
pubmed: 12374981
Cancer Cell. 2017 Jun 12;31(6):790-803.e8
pubmed: 28609657
Oncotarget. 2017 Dec 18;9(3):3752-3764
pubmed: 29423080
Cell. 2007 Jun 29;129(7):1311-23
pubmed: 17604720
Nat Biotechnol. 2011 Jul 31;29(8):742-9
pubmed: 21804560
Proc Natl Acad Sci U S A. 1974 Oct;71(10):3971-5
pubmed: 4372599
J Endocrinol. 1977 Jul;74(1):47-55
pubmed: 874417
Science. 2013 Mar 29;339(6127):1567-70
pubmed: 23539597
Genes Dev. 1995 Nov 1;9(21):2659-71
pubmed: 7590243
Dev Cell. 2010 Nov 16;19(5):698-711
pubmed: 21074720
Clin Epigenetics. 2015 Dec 12;7:128
pubmed: 26692910
Nature. 2015 Feb 19;518(7539):317-30
pubmed: 25693563
Nat Commun. 2018 Jun 19;9(1):2404
pubmed: 29921838
J Urol. 2007 Mar;177(3):822-31
pubmed: 17296351
Nat Genet. 2007 Feb;39(2):232-6
pubmed: 17200670
EBioMedicine. 2018 Sep;35:167-177
pubmed: 30100395
Curr Top Med Chem. 2018;18(28):2448-2457
pubmed: 30465505
Science. 2017 Jan 6;355(6320):84-88
pubmed: 28059768
Nat Struct Mol Biol. 2013 Jul;20(7):908-13
pubmed: 23728290
Science. 2012 Dec 14;338(6113):1465-9
pubmed: 23239736
Nat Commun. 2018 Oct 4;9(1):4080
pubmed: 30287808
Cancer Discov. 2012 Nov;2(11):1024-35
pubmed: 22930729
J Clin Invest. 2018 Oct 1;128(10):4472-4484
pubmed: 30047926
Int J Mol Sci. 2019 May 17;20(10):
pubmed: 31108832
J Clin Oncol. 2006 Jan 10;24(2):268-73
pubmed: 16330673
Proc Natl Acad Sci U S A. 2018 May 1;115(18):4530-4531
pubmed: 29666280
Anat Rec. 1973 Jan;175(1):87-96
pubmed: 4734188
Oncogene. 2002 Aug 12;21(35):5483-95
pubmed: 12154409
Dis Markers. 2016;2016:4358292
pubmed: 27594734
Oncogene. 2016 Feb 18;35(7):833-45
pubmed: 25961927
Nat Genet. 2020 Oct;52(10):1011-1017
pubmed: 32868907
Cancer Cell. 2019 Feb 11;35(2):297-314.e8
pubmed: 30753827
Sci Rep. 2019 Sep 16;9(1):13305
pubmed: 31527644
Epigenetics. 2006 Oct-Dec;1(4):183-6
pubmed: 17998819
Cancer Res. 2004 Mar 15;64(6):1975-86
pubmed: 15026333
Nat Commun. 2019 Jun 12;10(1):2571
pubmed: 31189930
Nat Med. 2016 Mar;22(3):298-305
pubmed: 26855148
J Clin Invest. 2020 Apr 1;130(4):1653-1668
pubmed: 32091413
Nature. 2012 Apr 29;485(7397):201-6
pubmed: 22575960
Cancer Cell Int. 2018 May 09;18:71
pubmed: 29760584
EMBO Rep. 2015 Dec;16(12):1609-19
pubmed: 26553936
Nature. 2017 Oct 5;550(7674):128-132
pubmed: 28953875
Nat Genet. 2018 May;50(5):645-651
pubmed: 29610475
Cells. 2019 May 22;8(5):
pubmed: 31121824
Clin Cancer Res. 2019 May 1;25(9):2755-2768
pubmed: 30587549
Mol Oncol. 2012 Dec;6(6):579-89
pubmed: 22963873
Epigenetics. 2016 Mar 3;11(3):184-93
pubmed: 26890396
Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15782-7
pubmed: 17043231
Nat Genet. 2007 Feb;39(2):157-8
pubmed: 17200673
Ann Oncol. 2020 Apr;31(4):470-479
pubmed: 32139297
Front Oncol. 2020 Mar 13;10:292
pubmed: 32231998
J Natl Cancer Inst. 2002 Mar 6;94(5):384-90
pubmed: 11880477
Oncogene. 2020 May;39(19):3939-3951
pubmed: 32203167
Cell Biosci. 2018 Jan 12;8:3
pubmed: 29344347
Onco Targets Ther. 2020 Aug 10;13:7921-7932
pubmed: 32884286
Science. 2018 Oct 5;362(6410):91-95
pubmed: 30287662
Genes Dev. 2009 Apr 1;23(7):781-3
pubmed: 19339683
Nucleic Acids Res. 2020 Apr 17;48(7):3935-3948
pubmed: 32055844
J Mol Diagn. 2017 Jan;19(1):107-114
pubmed: 27939865
Cancer Res. 2008 Nov 1;68(21):8954-67
pubmed: 18974140
Mol Oncol. 2013 Jun;7(3):555-66
pubmed: 23384557
Expert Rev Mol Diagn. 2019 May;19(5):367-375
pubmed: 30961397
Nat Genet. 2007 Apr;39(4):457-66
pubmed: 17334365
Trends Cell Biol. 2019 Aug;29(8):623-634
pubmed: 31153655
Proc Natl Acad Sci U S A. 2018 May 15;115(20):E4584-E4593
pubmed: 29712835
Cancer Cell. 2019 Mar 18;35(3):385-400.e9
pubmed: 30827887
Cancer Res. 2005 Jul 15;65(14):6305-11
pubmed: 16024632
Biochim Biophys Acta. 2015 Aug;1856(1):151-64
pubmed: 26208723
Leuk Res. 2009 Dec;33 Suppl 2:S12-7
pubmed: 20004791
Nat Genet. 2013 Nov;45(11):1392-8
pubmed: 24076601
J BUON. 2020 Jan-Feb;25(1):464-471
pubmed: 32277670
Asian J Urol. 2019 Jan;6(1):82-90
pubmed: 30775251
Nucleic Acids Res. 2019 Dec 16;47(22):11623-11636
pubmed: 31647098
Micromachines (Basel). 2018 Aug 10;9(8):
pubmed: 30424330
Curr Opin Genet Dev. 2006 Apr;16(2):125-36
pubmed: 16503131
Cancer Res. 2000 Jul 1;60(13):3623-30
pubmed: 10910077
Nat Genet. 2008 Jun;40(6):741-50
pubmed: 18488029
Nat Commun. 2020 Nov 3;11(1):5549
pubmed: 33144576
Cancer Invest. 2012 Feb;30(2):92-7
pubmed: 22149091
Cancer Epidemiol Biomarkers Prev. 2010 Oct;19(10):2611-22
pubmed: 20841388
Nucleic Acids Res. 2013 Apr;41(8):4433-46
pubmed: 23435229
Genome Res. 2012 Feb;22(2):322-31
pubmed: 22179855
Cancer Cell. 2010 May 18;17(5):443-54
pubmed: 20478527
Clin Epigenetics. 2016 Mar 15;8:32
pubmed: 26981160
Chem Biol. 2015 Sep 17;22(9):1185-96
pubmed: 26364928
Mol Cell. 2016 Sep 15;63(6):1080-8
pubmed: 27496019
Cancer Res. 2014 Mar 15;74(6):1651-60
pubmed: 24473064
Cell. 2008 Aug 8;134(3):521-33
pubmed: 18692474
Clin Chim Acta. 2010 Oct 9;411(19-20):1452-6
pubmed: 20573596
Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12979-84
pubmed: 18753622
Br J Cancer. 2004 Aug 31;91(5):985-94
pubmed: 15292941
Mol Cancer. 2016 Feb 24;15:18
pubmed: 26905733
Nat Biotechnol. 2009 Apr;27(4):361-8
pubmed: 19329998
J Clin Invest. 2019 Jul 1;129(9):3924-3940
pubmed: 31260412
Prostate. 2018 Apr;78(5):336-342
pubmed: 29330943
Cell Rep. 2016 Dec 6;17(10):2700-2714
pubmed: 27926872
Biochem Pharmacol. 2016 Apr 15;106:1-18
pubmed: 26707800
Sci Signal. 2019 Feb 26;12(570):
pubmed: 30808819
Mol Cell Biol. 2002 May;22(9):3157-73
pubmed: 11940673
Sci Transl Med. 2013 Jan 23;5(169):169ra10
pubmed: 23345608
Cancer Res. 2020 Aug 1;80(15):3074-3087
pubmed: 32522824
Clin Cancer Res. 2002 Feb;8(2):514-9
pubmed: 11839671
Genes Dev. 2002 Jan 1;16(1):6-21
pubmed: 11782440
Clin Epigenetics. 2020 Jun 5;12(1):80
pubmed: 32503656
Int J Mol Sci. 2019 Mar 07;20(5):
pubmed: 30866497
Cell Cycle. 2010 Nov 15;9(22):4477-86
pubmed: 21088488
Clin Cancer Res. 2017 Nov 15;23(22):7072-7083
pubmed: 28899973
Nat Commun. 2019 Sep 12;10(1):4154
pubmed: 31515496
Annu Rev Cell Dev Biol. 2017 Oct 6;33:319-342
pubmed: 28759256
Nature. 2005 Jun 30;435(7046):1262-6
pubmed: 15988529
Clin Cancer Res. 2016 Feb 15;22(4):984-92
pubmed: 26475336
Science. 2008 Dec 12;322(5908):1695-9
pubmed: 19008416
Dev Cell. 2019 Jul 22;50(2):184-196.e4
pubmed: 31204170
J Clin Oncol. 2013 Sep 10;31(26):3250-8
pubmed: 23918943
Nat Commun. 2021 Sep 7;12(1):5325
pubmed: 34493733
Nat Commun. 2020 Apr 24;11(1):1987
pubmed: 32332823
Cell Stem Cell. 2010 May 7;6(5):479-91
pubmed: 20452322
Genes (Basel). 2018 Nov 13;9(11):
pubmed: 30428628