Role of the HIPPO pathway as potential key player in the cross talk between oncology and cardiology.

Animals Cardiology Cell Proliferation Drosophila melanogaster / metabolism Hippo Signaling Pathway Humans Protein Serine-Threonine Kinases / genetics Signal Transduction
Cardiac development Cardiac regeneration Cardio-oncology HIPPO signaling pathway Tumor development

Journal

Critical reviews in oncology/hematology
ISSN: 1879-0461
Titre abrégé: Crit Rev Oncol Hematol
Pays: Netherlands
ID NLM: 8916049

Informations de publication

Date de publication:
Mar 2021
Historique:
received: 11 09 2020
revised: 20 01 2021
accepted: 21 01 2021
pubmed: 6 2 2021
medline: 9 3 2021
entrez: 5 2 2021
Statut: ppublish

Résumé

The HIPPO pathway (HP) is a highly conserved kinase cascade that affects organ size by regulating proliferation, cell survival and differentiation. Discovered in Drosophila melanogaster to early 2000, it immediately opened wide frontiers in the field of research. Over the last years the field of knowledge on HP is quickly expanding and it is thought will offer many answers on complex pathologies. Here, we summarized the results of several studies that have investigated HP signaling both in oncology than in cardiology field, with an overview on future perspectives in cardiology research.

Identifiants

DOI: 10.1016/j.critrevonc.2021.103246 PMID: 33545354
pubmed: 33545354
pii: S1040-8428(21)00034-2
doi: 10.1016/j.critrevonc.2021.103246
pii:
doi:

Substances chimiques

Protein Serine-Threonine Kinases EC 2.7.11.1

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

103246

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

Girolamo Manno (G)

Cardiology Unit, University Hospital P. Giaccone, Department of Excellence of Sciences for Health Promotion and Mothernal-Child Care, Internal Medicine and Specialities (ProMISE) "G. D'Alessandro", Palermo, Italy.

Clarissa Filorizzo (C)

Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, Italy.

Daniele Fanale (D)

Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, Italy.

Chiara Brando (C)

Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, Italy.

Daniela Di Lisi (D)

Cardiology Unit, University Hospital P. Giaccone, Department of Excellence of Sciences for Health Promotion and Mothernal-Child Care, Internal Medicine and Specialities (ProMISE) "G. D'Alessandro", Palermo, Italy.

Monica Lunetta (M)

Cardiology Unit, University Hospital P. Giaccone, Department of Excellence of Sciences for Health Promotion and Mothernal-Child Care, Internal Medicine and Specialities (ProMISE) "G. D'Alessandro", Palermo, Italy.

Viviana Bazan (V)

Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.), Section of Medical Oncology, Palermo, Italy.

Antonio Russo (A)

Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, Italy. Electronic address: antonio.russo@usa.net.

Giuseppina Novo (G)

Cardiology Unit, University Hospital P. Giaccone, Department of Excellence of Sciences for Health Promotion and Mothernal-Child Care, Internal Medicine and Specialities (ProMISE) "G. D'Alessandro", Palermo, Italy.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Role of the HIPPO pathway as potential key...
questionsmedicales.fr › Professions de santé › Médecine › Médecine interne › Cardiologie › Role of the HIPPO pathway as potential key...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Role of the HIPPO pathway as potential key...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Drosophilidae › Drosophila › Drosophila melanogaster › Role of the HIPPO pathway as potential key...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Voie de signalisation Hippo › Role of the HIPPO pathway as potential key...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Role of the HIPPO pathway as potential key...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Role of the HIPPO pathway as potential key...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Role of the HIPPO pathway as potential key...