Calpains for dummies: What you need to know about the calpain family.
Calcium
Calpain
Cysteine protease
Journal
Biochimica et biophysica acta. Proteins and proteomics
ISSN: 1878-1454
Titre abrégé: Biochim Biophys Acta Proteins Proteom
Pays: Netherlands
ID NLM: 101731734
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
16
11
2020
revised:
29
01
2021
accepted:
30
01
2021
pubmed:
6
2
2021
medline:
20
7
2021
entrez:
5
2
2021
Statut:
ppublish
Résumé
This review was written in memory of our late friend, Dr. Hiroyuki Sorimachi, who, following the steps of his mentor Koichi Suzuki, a pioneer in calpain research, has made tremendous contributions to the field. During his career, Hiro also wrote several reviews on calpain, the last of which, published in 2016, was comprehensive. In this manuscript, we decided to put together a review with the basic information a novice may need to know about calpains. We also tried to avoid similarities with previous reviews and reported the most significant new findings, at the same time highlighting Hiro's contributions to the field. The review will cover a short history of calpain discovery, the presentation of the family, the life of calpain from transcription to activity, human diseases caused by calpain mutations and therapeutic perspectives.
Identifiants
pubmed: 33545367
pii: S1570-9639(21)00022-4
doi: 10.1016/j.bbapap.2021.140616
pii:
doi:
Substances chimiques
Calpain
EC 3.4.22.-
Proteasome Endopeptidase Complex
EC 3.4.25.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
140616Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.