CD3
CCL17/TARC
CD3(−)CD4(+) T cells
Hypereosinophilic syndrome
IL-5
Intracytoplasmic cytokines
Lymphocytic variant
T-cell phenotyping
TCR gene rearrangement
Journal
The journal of allergy and clinical immunology. In practice
ISSN: 2213-2201
Titre abrégé: J Allergy Clin Immunol Pract
Pays: United States
ID NLM: 101597220
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
07
10
2020
revised:
13
01
2021
accepted:
16
01
2021
pubmed:
6
2
2021
medline:
9
7
2021
entrez:
5
2
2021
Statut:
ppublish
Résumé
Identification of patients with lymphocytic variant hypereosinophilic syndrome (L-HES) is challenging, and has important prognostic and therapeutic implications. This study was undertaken to assess diagnostic tools for L-HES and to develop evidence-based diagnostic recommendations. Biomarkers of T-cell-driven disease were compared between patients with L-HES versus idiopathic HES (I-HES) variants. Those performed routinely (serum immunoglobulin levels, T-cell phenotyping, T-cell receptor [TCR] gene rearrangement patterns) were collected from medical files, whereas others were prospectively assessed on stored blood samples (serum CCL17/thymus and activation regulated chemokine [TARC] levels, in vitro cytokine production). This study included 48 patients with I-HES and 20 with L-HES associated with a CD3 Adapting the standard of procedure for T-cell phenotyping in patients with unexplained hypereosinophilia is currently the most reliable means of identifying those with CD3
Sections du résumé
BACKGROUND
Identification of patients with lymphocytic variant hypereosinophilic syndrome (L-HES) is challenging, and has important prognostic and therapeutic implications.
OBJECTIVE
This study was undertaken to assess diagnostic tools for L-HES and to develop evidence-based diagnostic recommendations.
METHODS
Biomarkers of T-cell-driven disease were compared between patients with L-HES versus idiopathic HES (I-HES) variants. Those performed routinely (serum immunoglobulin levels, T-cell phenotyping, T-cell receptor [TCR] gene rearrangement patterns) were collected from medical files, whereas others were prospectively assessed on stored blood samples (serum CCL17/thymus and activation regulated chemokine [TARC] levels, in vitro cytokine production).
RESULTS
This study included 48 patients with I-HES and 20 with L-HES associated with a CD3
CONCLUSION
Adapting the standard of procedure for T-cell phenotyping in patients with unexplained hypereosinophilia is currently the most reliable means of identifying those with CD3
Identifiants
pubmed: 33545400
pii: S2213-2198(21)00158-6
doi: 10.1016/j.jaip.2021.01.030
pii:
doi:
Substances chimiques
CD3 Complex
0
Cytokines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2426-2439.e7Informations de copyright
Copyright © 2021 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.