Enantiomeric resolution of quinolones on crown ether CSP: Thermodynamics, chiral discrimination mechanism and application in biological samples.
Chiral crown ether
Enantio-resolution
Mechanism
Modeling
Quinolones
Thermodynamics
Journal
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
ISSN: 1873-376X
Titre abrégé: J Chromatogr B Analyt Technol Biomed Life Sci
Pays: Netherlands
ID NLM: 101139554
Informations de publication
Date de publication:
01 Mar 2021
01 Mar 2021
Historique:
received:
06
12
2020
revised:
03
01
2021
accepted:
10
01
2021
pubmed:
6
2
2021
medline:
1
6
2021
entrez:
5
2
2021
Statut:
ppublish
Résumé
The enantiomers of quinolone racemates were resolved using chiral crown ether within 8 min. Thermodynamics data and modeling results were used to determine chiral recognition mechanism. The column used was (+)-Crownpack column (250 mm × 4.6 mm, 5 µm) with three mobile phases I: ACN:Water (80:20) + 10 mM H
Identifiants
pubmed: 33545563
pii: S1570-0232(21)00029-5
doi: 10.1016/j.jchromb.2021.122550
pii:
doi:
Substances chimiques
Crown Ethers
0
Quinolones
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
122550Informations de copyright
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