Invasive and Noninvasive Nonfunctioning Gonadotroph Pituitary Tumors Differ in DNA Methylation Level of LINE-1 Repetitive Elements.
DNA methylation
L1-ORF1p
LINE-1
gonadotropinoma
invasive growth
pituitary tumor
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
03 Feb 2021
03 Feb 2021
Historique:
received:
24
12
2020
revised:
22
01
2021
accepted:
26
01
2021
entrez:
6
2
2021
pubmed:
7
2
2021
medline:
7
2
2021
Statut:
epublish
Résumé
Epigenetic dysregulation plays a role in pituitary tumor pathogenesis. Some differences in DNA methylation were observed between invasive and noninvasive nonfunctioning gonadotroph tumors. This study sought to determine the role of DNA methylation changes in repetitive LINE-1 elements in nonfunctioning gonadotroph pituitary tumors. We investigated LINE-1 methylation levels in 80 tumors and normal pituitary glands with bisulfite-pyrosequencing. Expression of two LINE-1 open reading frames ( Hypomethylation of LINE-1 was observed in pituitary tumors. Tumors characterized by invasive growth revealed lower LINE-1 methylation level than noninvasive ones. LINE-1 methylation correlated with overall DNA methylation assessed with HM450K arrays and negatively correlated with Hypomethylation of LINE-1 is related to invasive growth and influences transcriptional activity of transposable elements.
Identifiants
pubmed: 33546126
pii: jcm10040560
doi: 10.3390/jcm10040560
pmc: PMC7913198
pii:
doi:
Types de publication
Journal Article
Langues
eng
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