Rheumatoid Factor: A Novel Determiner in Cancer History.
autoantibodies
autoimmunity
biomarker
cancer
cancer development
cancer progression
cancer susceptibility
immunotherapy
predictive biomarker
prognostic biomarker
rheumatoid factor
tumor load
tumor recurrence
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
03 Feb 2021
03 Feb 2021
Historique:
received:
17
12
2020
revised:
25
01
2021
accepted:
01
02
2021
entrez:
6
2
2021
pubmed:
7
2
2021
medline:
7
2
2021
Statut:
epublish
Résumé
The possible interplay between autoimmunity and cancer is a topic that still needs to be deeply explored. Rheumatoid factors are autoantibodies that are able to bind the constant regions (Fc) of immunoglobulins class G (IgGs). In physiological conditions, their production is a transient event aimed at contributing to the elimination of pathogens as well as limiting a redundant immune response by facilitating the clearance of antibodies and immune complexes. Their production can become persistent in case of different chronic infections or diseases, being for instance a fundamental marker for the diagnosis and prognosis of rheumatoid arthritis. Their presence is also associated with aging. Some studies highlighted how elevated levels of rheumatoid factors (RFs) in the blood of patients are correlated with an increased cancer risk, tumor recurrence, and load and with a reduced response to anti-tumor immunotherapies. In line with their physiological roles, RFs showed in different works the ability to impair in vitro anti-cancer immune responses and effector functions, suggesting their potential immunosuppressive activity in the context of tumor immunity. Thus, the aim of this review is to investigate the emerging role of RFs as determiners of cancer faith.
Identifiants
pubmed: 33546243
pii: cancers13040591
doi: 10.3390/cancers13040591
pmc: PMC7913362
pii:
doi:
Types de publication
Journal Article
Langues
eng
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