Brown Adipose Tissue and Its Role in Insulin and Glucose Homeostasis.
brown adipose tissue
diabetes type 2
insulin resistance
metabolism
obesity
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
03 Feb 2021
03 Feb 2021
Historique:
received:
16
12
2020
revised:
21
01
2021
accepted:
01
02
2021
entrez:
6
2
2021
pubmed:
7
2
2021
medline:
20
4
2021
Statut:
epublish
Résumé
The increased worldwide prevalence of obesity, insulin resistance, and their related metabolic complications have prompted the scientific world to search for new possibilities to combat obesity. Brown adipose tissue (BAT), due to its unique protein uncoupling protein 1 (UPC1) in the inner membrane of the mitochondria, has been acknowledged as a promising approach to increase energy expenditure. Activated brown adipocytes dissipate energy, resulting in heat production. In other words, BAT burns fat and increases the metabolic rate, promoting a negative energy balance. Moreover, BAT alleviates metabolic complications like dyslipidemia, impaired insulin secretion, and insulin resistance in type 2 diabetes. The aim of this review is to explore the role of BAT in total energy expenditure, as well as lipid and glucose homeostasis, and to discuss new possible activators of brown adipose tissue in humans to treat obesity and metabolic disorders.
Identifiants
pubmed: 33546400
pii: ijms22041530
doi: 10.3390/ijms22041530
pmc: PMC7913527
pii:
doi:
Substances chimiques
Biomarkers
0
Insulin
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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