In vivo tau pathology is associated with synaptic loss and altered synaptic function.
Alzheimer
MEG
PET
Synaptic density
Synaptic function
Tau
Journal
Alzheimer's research & therapy
ISSN: 1758-9193
Titre abrégé: Alzheimers Res Ther
Pays: England
ID NLM: 101511643
Informations de publication
Date de publication:
05 02 2021
05 02 2021
Historique:
received:
03
08
2020
accepted:
11
01
2021
entrez:
6
2
2021
pubmed:
7
2
2021
medline:
25
6
2021
Statut:
epublish
Résumé
The mechanism of synaptic loss in Alzheimer's disease is poorly understood and may be associated with tau pathology. In this combined positron emission tomography (PET) and magnetoencephalography (MEG) study, we aimed to investigate spatial associations between regional tau pathology ([ Seven amyloid-positive Alzheimer's disease subjects from the Amsterdam Dementia Cohort underwent dynamic 130-min [ Across subjects, higher regional [ These results indicate that in Alzheimer's disease, tau pathology is closely associated with reduced synaptic density and synaptic dysfunction.
Sections du résumé
BACKGROUND
The mechanism of synaptic loss in Alzheimer's disease is poorly understood and may be associated with tau pathology. In this combined positron emission tomography (PET) and magnetoencephalography (MEG) study, we aimed to investigate spatial associations between regional tau pathology ([
METHODS
Seven amyloid-positive Alzheimer's disease subjects from the Amsterdam Dementia Cohort underwent dynamic 130-min [
RESULTS
Across subjects, higher regional [
CONCLUSIONS
These results indicate that in Alzheimer's disease, tau pathology is closely associated with reduced synaptic density and synaptic dysfunction.
Identifiants
pubmed: 33546722
doi: 10.1186/s13195-021-00772-0
pii: 10.1186/s13195-021-00772-0
pmc: PMC7866464
doi:
Substances chimiques
Amyloid
0
tau Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
35Références
Neurobiol Aging. 2011 Dec;32 Suppl 1:S37-43
pubmed: 22078171
J Cereb Blood Flow Metab. 2018 Nov;38(11):2041-2052
pubmed: 28792356
Neuron. 2014 May 21;82(4):756-71
pubmed: 24853936
Eur J Nucl Med Mol Imaging. 2019 Feb;46(2):396-406
pubmed: 30121895
Sci Transl Med. 2016 Jul 20;8(348):348ra96
pubmed: 27440727
Nat Neurosci. 2016 Aug;19(8):1085-92
pubmed: 27322420
Alzheimers Dement. 2020 Jul;16(7):974-982
pubmed: 32400950
Neuroimage. 2005 Feb 15;24(4):969-79
pubmed: 15670674
Ann Neurol. 2016 Aug;80(2):247-58
pubmed: 27323247
J Neurol Neurosurg Psychiatry. 1992 Oct;55(10):967-72
pubmed: 1431963
Ann Neurol. 1991 Oct;30(4):572-80
pubmed: 1789684
Acta Neuropathol. 2015 Jun;129(6):875-94
pubmed: 25862635
Alzheimers Dement. 2018 Apr;14(4):535-562
pubmed: 29653606
Neuroimage. 2012 Feb 15;59(4):3909-21
pubmed: 22122866
Hum Brain Mapp. 2003 Aug;19(4):224-47
pubmed: 12874777
Neurology. 2020 Aug 4;95(5):e545-e553
pubmed: 32493717
Clin Neurophysiol. 2013 May;124(5):837-50
pubmed: 23098644
J Neuropathol Exp Neurol. 1999 Mar;58(3):275-87
pubmed: 10197819
Phys Med Biol. 2006 Apr 7;51(7):1759-68
pubmed: 16552102
Hum Brain Mapp. 2007 Mar;28(3):228-37
pubmed: 16767769
J Alzheimers Dis. 2018;62(3):1091-1111
pubmed: 29562540
J Neurochem. 2015 May;133(3):368-79
pubmed: 25393609
PLoS Comput Biol. 2012;8(8):e1002582
pubmed: 22915996
Eur J Nucl Med Mol Imaging. 2020 Feb;47(2):390-402
pubmed: 31468182
IEEE Trans Biomed Eng. 2004 Oct;51(10):1726-34
pubmed: 15490820
J Neurosci. 2019 Jan 16;39(3):548-556
pubmed: 30482786
PLoS One. 2012;7(2):e31302
pubmed: 22312444
Brain. 2017 Dec 1;140(12):3286-3300
pubmed: 29053874
EJNMMI Res. 2017 Dec;7(1):36
pubmed: 28432674
EMBO Rep. 2013 Apr;14(4):389-94
pubmed: 23412472
Clin Neurophysiol. 2013 Jan;124(1):107-13
pubmed: 22832101
Clin Neurophysiol. 2018 Aug;129(8):1720-1747
pubmed: 29724661
Nat Commun. 2017 May 11;8:15295
pubmed: 28492240
Front Hum Neurosci. 2016 May 20;10:238
pubmed: 27242496
Neurology. 2019 Feb 5;92(6):e601-e612
pubmed: 30626656
Brain Cogn. 2010 Feb;72(1):86-100
pubmed: 19914761
Neuron. 2007 Sep 6;55(5):697-711
pubmed: 17785178
J Cereb Blood Flow Metab. 2021 Jun;41(6):1338-1350
pubmed: 34013797
Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):3867-72
pubmed: 27001844
Neuron. 2016 Mar 2;89(5):971-982
pubmed: 26938442
Hum Brain Mapp. 2019 Apr 1;40(5):1594-1607
pubmed: 30421472
J Exp Med. 2014 Mar 10;211(3):387-93
pubmed: 24534188
Clin Neurophysiol. 2017 Aug;128(8):1426-1437
pubmed: 28622527
Mol Imaging Biol. 2017 Dec;19(6):963-971
pubmed: 28374171
Int Rev Neurobiol. 2005;68:149-71
pubmed: 16443013
Mol Neurodegener. 2011 Jun 06;6:39
pubmed: 21645391
Neuron. 2015 Mar 4;85(5):959-66
pubmed: 25704951
Clin Neurophysiol. 2009 May;120(5):910-5
pubmed: 19386543
Neurobiol Aging. 2017 Sep;57:133-142
pubmed: 28646686
Neuroimage. 2017 Sep;158:70-78
pubmed: 28676297
Ann Neurol. 1990 May;27(5):457-64
pubmed: 2360787
J Neurosci. 2017 Apr 19;37(16):4323-4331
pubmed: 28314821
Neuron. 2009 May 28;62(4):566-77
pubmed: 19477157
Brain Pathol. 2012 Nov;22(6):826-33
pubmed: 22486774
J Cereb Blood Flow Metab. 2020 Feb;40(2):365-373
pubmed: 30569813
Clin Neurophysiol. 2004 Jul;115(7):1490-505
pubmed: 15203050
Mol Cell Neurosci. 2019 Jun;97:34-42
pubmed: 30796959
Brain. 2016 May;139(Pt 5):1551-67
pubmed: 26962052
Lancet. 2016 Jul 30;388(10043):505-17
pubmed: 26921134
Am J Pathol. 2008 Jun;172(6):1683-92
pubmed: 18467692
Clin Neurophysiol. 2007 Aug;118(8):1691-704
pubmed: 17587643
Ann Neurol. 2000 Jul;48(1):77-87
pubmed: 10894219
Neuron. 2013 Dec 4;80(5):1112-28
pubmed: 24314724
Sci Transl Med. 2020 Mar 11;12(534):
pubmed: 32161102
Ann Neurol. 2015 Feb;77(2):338-42
pubmed: 25448043
Alzheimers Dement. 2011 May;7(3):263-9
pubmed: 21514250
Neuromolecular Med. 2010 Mar;12(1):48-55
pubmed: 19838821
JAMA Neurol. 2018 Oct 1;75(10):1215-1224
pubmed: 30014145
Brain Connect. 2019 Sep;9(7):539-553
pubmed: 31115272