Proliferative glomerulonephritis and mantle cell lymphoma: a rare association.
Antibodies, Antineutrophil Cytoplasmic
/ blood
Antineoplastic Combined Chemotherapy Protocols
Biomarkers, Tumor
/ blood
Biopsy
Cyclophosphamide
Diagnosis, Differential
Doxorubicin
Glomerulonephritis
/ drug therapy
Humans
Lymphoma, Mantle-Cell
/ complications
Male
Middle Aged
Prednisone
Rituximab
Vincristine
acute renal failure
malignant and benign haematology
vasculitis
Journal
BMJ case reports
ISSN: 1757-790X
Titre abrégé: BMJ Case Rep
Pays: England
ID NLM: 101526291
Informations de publication
Date de publication:
05 Feb 2021
05 Feb 2021
Historique:
entrez:
6
2
2021
pubmed:
7
2
2021
medline:
23
2
2021
Statut:
epublish
Résumé
Renal involvement in mantle cell lymphoma (MCL) is rare. We present the case of a man followed for MCL presented with acute kidney injury and positive antineutrophil cytoplasmic antibody (ANCA) type anti proteinase 3 (PR3). He was treated as for a rapidly progressing glomerulonephritis with cyclophosphamide and methylprednisolone followed by oral prednisone. Renal biopsy revealed diffuse endocapillary proliferation and segmental extracapillary proliferation in four glomeruli. Immunohistochemistry confirmed the renal invasion of lymphomatous cells. He started improving his renal function shortly after starting treatment. The coexistence of renal MCL infiltration, extracapillary proliferation and ANCA positive is exceptional.
Identifiants
pubmed: 33547121
pii: 14/2/e238153
doi: 10.1136/bcr-2020-238153
pmc: PMC7871245
pii:
doi:
Substances chimiques
Antibodies, Antineutrophil Cytoplasmic
0
Biomarkers, Tumor
0
R-CHOP protocol
0
Rituximab
4F4X42SYQ6
Vincristine
5J49Q6B70F
Doxorubicin
80168379AG
Cyclophosphamide
8N3DW7272P
Prednisone
VB0R961HZT
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© BMJ Publishing Group Limited 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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