Sensing soluble uric acid by Naip1-Nlrp3 platform.

Animals Fatty Acids / metabolism Humans Inflammasomes / genetics Interleukin-1beta / metabolism Macaca mulatta Macrophages / drug effects Mice, Inbred C57BL NLR Family, Pyrin Domain-Containing 3 Protein / genetics Neuronal Apoptosis-Inhibitory Protein / genetics Protein Binding THP-1 Cells Uric Acid / metabolism

Journal

Cell death & disease
ISSN: 2041-4889
Titre abrégé: Cell Death Dis
Pays: England
ID NLM: 101524092

Informations de publication

Date de publication:
05 02 2021
Historique:
received: 17 11 2020
accepted: 15 01 2021
revised: 11 01 2021
entrez: 6 2 2021
pubmed: 7 2 2021
medline: 14 9 2021
Statut: epublish

Résumé

Uric acid (UA), a product of purine nucleotide degradation able to initiate an immune response, represents a breakpoint in the evolutionary history of humans, when uricase, the enzyme required for UA cleavage, was lost. Despite being inert in human cells, UA in its soluble form (sUA) can increase the level of interleukin-1β (IL-1β) in murine macrophages. We, therefore, hypothesized that the recognition of sUA is achieved by the Naip1-Nlrp3 inflammasome platform. Through structural modelling predictions and transcriptome and functional analyses, we found that murine Naip1 expression in human macrophages induces IL-1β expression, fatty acid production and an inflammation-related response upon sUA stimulation, a process reversed by the pharmacological and genetic inhibition of Nlrp3. Moreover, molecular interaction experiments showed that Naip1 directly recognizes sUA. Accordingly, Naip may be the sUA receptor lost through the human evolutionary process, and a better understanding of its recognition may lead to novel anti-hyperuricaemia therapies.

Identifiants

DOI: 10.1038/s41419-021-03445-w PMID: 33547278 PMC: PMC7864962
pubmed: 33547278
doi: 10.1038/s41419-021-03445-w
pii: 10.1038/s41419-021-03445-w
pmc: PMC7864962
doi:

Substances chimiques

Fatty Acids 0
IL1B protein, human 0
Inflammasomes 0
Interleukin-1beta 0
NAIP protein, human 0
NLR Family, Pyrin Domain-Containing 3 Protein 0
NLRP3 protein, human 0
Naip1 protein, mouse 0
Neuronal Apoptosis-Inhibitory Protein 0
Nlrp3 protein, mouse 0
Uric Acid 268B43MJ25

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

158

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Auteurs

Tarcio Teodoro Braga (TT)

Department of Basic Pathology, Federal University of Parana, Curitiba, PR, Brazil. tarcio.braga@ufpr.br.
Department of Immunology, Institute of Biomedical Sciences IV, University of São Paulo, São Paulo, SP, Brazil. tarcio.braga@ufpr.br.
Institute of Innate Immunity, University Hospitals Bonn, Bonn, Germany. tarcio.braga@ufpr.br.
ORCID: 0000-0002-2989-1076

Mariana Rodrigues Davanso (MR)

Department of Immunology, Institute of Biomedical Sciences IV, University of São Paulo, São Paulo, SP, Brazil.
Institute of Innate Immunity, University Hospitals Bonn, Bonn, Germany.
Department of Physiology and Biophysics, Institute of Biomedical Sciences I, University of Sao Paulo, São Paulo, SP, Brazil.

Davi Mendes (D)

Department of Microbiology, Institute of Biomedical Sciences II, University of São Paulo, São Paulo, SP, Brazil.
ORCID: 0000-0002-9524-4424

Tiago Antonio de Souza (TA)

Department of Microbiology, Institute of Biomedical Sciences II, University of São Paulo, São Paulo, SP, Brazil.

Anderson Fernandes de Brito (AF)

Department of Life Sciences, Imperial College London, London, SW7 2AZ, UK.

Mario Costa Cruz (MC)

Department of Immunology, Institute of Biomedical Sciences IV, University of São Paulo, São Paulo, SP, Brazil.

Meire Ioshie Hiyane (MI)

Department of Immunology, Institute of Biomedical Sciences IV, University of São Paulo, São Paulo, SP, Brazil.

Dhemerson Souza de Lima (DS)

Department of Immunology, Institute of Biomedical Sciences IV, University of São Paulo, São Paulo, SP, Brazil.

Vinicius Nunes (V)

Department of Immunology, Institute of Biomedical Sciences IV, University of São Paulo, São Paulo, SP, Brazil.

Juliana de Fátima Giarola (J)

Institute of Chemistry, University of Campinas, Campinas, SP, Brazil.

Denio Emanuel Pires Souto (DEP)

Institute of Chemistry, University of Campinas, Campinas, SP, Brazil.
Department of Chemistry, Federal University of Parana, Curitiba, PR, Brazil.

Tomasz Próchnicki (T)

Institute of Innate Immunity, University Hospitals Bonn, Bonn, Germany.

Mario Lauterbach (M)

Institute of Innate Immunity, University Hospitals Bonn, Bonn, Germany.

Stellee Marcela Petris Biscaia (SMP)

Department of Cellular Biology, Federal University of Parana, Curitiba, PR, Brazil.

Rilton Alves de Freitas (RA)

Department of Chemistry, Federal University of Parana, Curitiba, PR, Brazil.

Rui Curi (R)

Department of Physiology and Biophysics, Institute of Biomedical Sciences I, University of Sao Paulo, São Paulo, SP, Brazil.
Interdisciplinary Post-Graduate Program in Health Sciences, Cruzeiro do Sul University, São Paulo, Brazil.

Alessandra Pontillo (A)

Department of Immunology, Institute of Biomedical Sciences IV, University of São Paulo, São Paulo, SP, Brazil.

Eicke Latz (E)

Institute of Innate Immunity, University Hospitals Bonn, Bonn, Germany.
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, 01655, USA.
Centre for Molecular Inflammation Research (CEMIR), Norwegian University of Science and Technology, 7491, Trondheim, Norway.
ORCID: 0000-0003-1488-5666

Niels Olsen Saraiva Camara (NOS)

Department of Immunology, Institute of Biomedical Sciences IV, University of São Paulo, São Paulo, SP, Brazil.
Nephrology Division, Federal University of São Paulo, São Paulo, SP, Brazil.
Renal Physiopathology Laboratory, Faculty of Medicine, University of São Paulo, São Paulo, SP, Brazil.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Sensing soluble uric acid by Naip1-Nlrp3 platform.
questionsmedicales.fr › Lipides › Acides gras › Sensing soluble uric acid by Naip1-Nlrp3 platform.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Sensing soluble uric acid by Naip1-Nlrp3 platform.
questionsmedicales.fr › Structures macromoléculaires › Complexes multiprotéiques › Inflammasomes › Sensing soluble uric acid by Naip1-Nlrp3 platform.
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Monokines › Interleukine-1 › Interleukine-1 bêta › Sensing soluble uric acid by Naip1-Nlrp3 platform.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca › Macaca mulatta › Sensing soluble uric acid by Naip1-Nlrp3 platform.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Sensing soluble uric acid by Naip1-Nlrp3 platform.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Sensing soluble uric acid by Naip1-Nlrp3 platform.
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Protéines NLR › Protéine-3 de la famille des NLR contenant un domaine pyrine › Sensing soluble uric acid by Naip1-Nlrp3 platform.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Protéine inhibitrice de l'apoptose neuronale › Sensing soluble uric acid by Naip1-Nlrp3 platform.
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Sensing soluble uric acid by Naip1-Nlrp3 platform.
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Cellules THP-1 › Sensing soluble uric acid by Naip1-Nlrp3 platform.
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Purines › Purinones › Xanthines › Acide urique › Sensing soluble uric acid by Naip1-Nlrp3 platform.