Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation.
Aminopyridines
/ chemistry
Azepines
/ chemistry
Binding Sites
Cloning, Molecular
Cryoelectron Microscopy
Escherichia coli
/ genetics
Gene Expression
Genetic Vectors
/ chemistry
HEK293 Cells
Humans
Molecular Dynamics Simulation
Orexin Receptor Antagonists
/ chemistry
Orexin Receptors
/ agonists
Peptides
/ chemistry
Protein Binding
Protein Conformation, alpha-Helical
Protein Conformation, beta-Strand
Protein Interaction Domains and Motifs
Recombinant Proteins
/ chemistry
Sleep Aids, Pharmaceutical
/ chemistry
Sulfonamides
/ chemistry
Triazoles
/ chemistry
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
05 02 2021
05 02 2021
Historique:
received:
30
07
2020
accepted:
05
01
2021
entrez:
6
2
2021
pubmed:
7
2
2021
medline:
18
2
2021
Statut:
epublish
Résumé
Narcolepsy type 1 (NT1) is a chronic neurological disorder that impairs the brain's ability to control sleep-wake cycles. Current therapies are limited to the management of symptoms with modest effectiveness and substantial adverse effects. Agonists of the orexin receptor 2 (OX
Identifiants
pubmed: 33547286
doi: 10.1038/s41467-021-21087-6
pii: 10.1038/s41467-021-21087-6
pmc: PMC7864924
doi:
Substances chimiques
Aminopyridines
0
Azepines
0
HCRTR2 protein, human
0
N-ethyl-2-((6-methoxy-pyridin-3-yl)-(toluene-2-sulphonyl)amino)-N-pyridin-3-ylmethyl-acetamide
0
Orexin Receptor Antagonists
0
Orexin Receptors
0
Peptides
0
Recombinant Proteins
0
Sleep Aids, Pharmaceutical
0
Sulfonamides
0
Triazoles
0
suvorexant
081L192FO9
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
815Références
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