The independent and interactive associations of physical activity intensity and vitamin D status with bone mineral density in prepubertal children: the PANIC Study.
Accelerometery
Bone mass
Childhood
DXA
Growth
Journal
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
ISSN: 1433-2965
Titre abrégé: Osteoporos Int
Pays: England
ID NLM: 9100105
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
27
04
2020
accepted:
01
02
2021
pubmed:
7
2
2021
medline:
24
8
2021
entrez:
6
2
2021
Statut:
ppublish
Résumé
It is unclear how physical activity intensity and vitamin D status are related to bone health in prepubertal children. We found positive associations between vitamin D status and moderate-to-vigorous physical activity with bone in boys and girls. This highlights the importance of lifestyle factors for skeletal health prepuberty. The sex-specific independent and interactive associations of physical activity (PA) intensity and serum 25-hydroxyvitamin D (25(OH)D) levels with areal bone mineral density (aBMD) were investigated in prepubertal children. The participants were 366 prepubertal Finnish children (190 boys, 176 girls) aged 6-8 years. Linear regression analysed the associations of sedentary time (ST), light PA (LPA), moderate PA (MPA), moderate-to-vigorous PA (MVPA) and vigorous PA (VPA) measured by accelerometery, and serum 25(OH)D with total body less head (TBLH) and lower-limb aBMD, measured by dual-energy X-ray absorptiometry. There was no interaction between PA intensity or serum 25(OH)D and sex with aBMD. MPA and MVPA were positively associated with TBLH and lower-limb aBMD (β = 0.11, 95% CI 0.02-0.20, p = 0.01). Serum 25(OH)D was positively associated with TBLH and lower-limb aBMD (β = 0.09, 95% CI 0.01-0.18, p = 0.03). There were no interactions between PA intensity and serum 25(OH)D with aBMD. Vitamin D status, MPA and MVPA levels in active prepubertal children were positively associated with aBMD. The influence of MVPA is due to the MPA component, though our findings regarding the role of VPA should be interpreted with caution, as shorter accelerometer epochs are needed to more accurately assess VPA. This study adds evidence to the promotion of MPA and behaviours to encourage optimal vitamin D status in supporting skeletal health in childhood, though these need not be used in conjunction to be beneficial, and a sex-specific approach is not necessary in prepubertal children. NCT01803776 . Date of registration: 4/03/2013.
Identifiants
pubmed: 33547487
doi: 10.1007/s00198-021-05872-z
pii: 10.1007/s00198-021-05872-z
doi:
Substances chimiques
Vitamin D
1406-16-2
Banques de données
ClinicalTrials.gov
['NCT01803776']
Types de publication
Controlled Clinical Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1609-1620Subventions
Organisme : Medical Research Council
ID : MC_UU_00006/4
Pays : United Kingdom
Organisme : UK Medical Research Council
ID : MC_UU_12015/3
Organisme : NIHR Cambridge Biomedical Research Centre
ID : IS-BRC-1215-20014
Informations de copyright
© 2021. International Osteoporosis Foundation and National Osteoporosis Foundation.
Références
Baxter-Jones AD, Faulkner RA, Forwood MR, Mirwald RL, Bailey DA (2011) Bone mineral accrual from 8 to 30 years of age: an estimation of peak bone mass. J Bone Miner Res 26(8):1729–1739. https://doi.org/10.1002/jbmr.412
doi: 10.1002/jbmr.412
pubmed: 21520276
Bailey DA, McKay HA, Mirwald RL, Crocker PR, Faulkner RA (1999) A six-year longitudinal study of the relationship of physical activity to bone mineral accrual in growing children: the university of Saskatchewan bone mineral accrual study. J Bone Miner Res 14(10):1672–1679. https://doi.org/10.1359/jbmr.1999.14.10.1672
doi: 10.1359/jbmr.1999.14.10.1672
pubmed: 10491214
Weaver CM, Gordon CM, Janz KF, Kalkwarf HJ, Lappe JM, Lewis R, O’Karma M, Wallace TC, Zemel BS (2016) The National Osteoporosis Foundation’s position statement on peak bone mass development and lifestyle factors: a systematic review and implementation recommendations. Osteoporos Int 27(4):1281–1386. https://doi.org/10.1007/s00198-015-3440-3
doi: 10.1007/s00198-015-3440-3
pubmed: 26856587
pmcid: 4791473
Clark EM, Ness AR, Bishop NJ, Tobias JH (2006) Association between bone mass and fractures in children: a prospective cohort study. J Bone Miner Res 21(9):1489–1495. https://doi.org/10.1359/jbmr.060601
doi: 10.1359/jbmr.060601
pubmed: 16939408
Janz KF, Burns TL, Torner JC, Levy SM, Paulos R, Willing MC, Warren JJ (2001) Physical activity and bone measures in young children: the Iowa bone development study. Pediatrics 107(6):1387–1393. https://doi.org/10.1542//peds.107.6.1387
doi: 10.1542//peds.107.6.1387
pubmed: 11389262
Tobias JH, Steer CD, Mattocks CG, Riddoch C, Ness AR (2007) Habitual levels of physical activity influence bone mass in 11-year-old children from the United Kingdom: findings from a large population-based cohort. J Bone Miner Res 22(1):101–109. https://doi.org/10.1359/jbmr.060913
doi: 10.1359/jbmr.060913
pubmed: 17014381
Gracia-Marco L, Moreno LA, Ortega FB, Leon F, Sioen I, Kafatos A, Martinez-Gomez D, Widhalm K, Castillo MJ, Vicente-Rodriguez G, Group HS (2011) Levels of physical activity that predict optimal bone mass in adolescents: the HELENA study. Am J Prev Med 40(6):599–607. https://doi.org/10.1016/j.amepre.2011.03.001
doi: 10.1016/j.amepre.2011.03.001
pubmed: 21565650
Vlachopoulos D, Barker AR, Williams CA, SA AR, Knapp KM, Metcalf BS, Fatouros IG, Moreno LA, Gracia-Marco L (2017) The impact of sport participation on bone mass and geometry in male adolescents. Med Sci Sports Exerc 49(2):317–326. https://doi.org/10.1249/MSS.0000000000001091
doi: 10.1249/MSS.0000000000001091
pubmed: 27631395
MacKelvie KJ, Khan KM, McKay HA (2002) Is there a critical period for bone response to weight-bearing exercise in children and adolescents? A systematic review. Br J Sports Med 36(4):250–257 discussion 257
doi: 10.1136/bjsm.36.4.250
Harvey NC, Cole ZA, Crozier SR, Kim M, Ntani G, Goodfellow L, Robinson SM, Inskip HM, Godfrey KM, Dennison EM, Wareham N, Ekelund U, Cooper C, S. W. S. Study Group (2012) Physical activity, calcium intake and childhood bone mineral: a population-based cross-sectional study. Osteoporos Int 23(1):121–130. https://doi.org/10.1007/s00198-011-1641-y
doi: 10.1007/s00198-011-1641-y
pubmed: 21562877
Hazell TJ, Pham TT, Jean-Philippe S, Finch SL, El Hayek J, Vanstone CA, Agellon S, Rodd CJ, Weiler HA (2015) Vitamin D status is associated with bone mineral density and bone mineral content in preschool-aged children. J Clin Densitom 18(1):60–67. https://doi.org/10.1016/j.jocd.2014.04.121
doi: 10.1016/j.jocd.2014.04.121
pubmed: 24880497
Pekkinen M, Viljakainen H, Saarnio E, Lamberg-Allardt C, Mäkitie O (2012) Vitamin D is a major determinant of bone mineral density at school age. PLoS One 7(7):e40090. https://doi.org/10.1371/journal.pone.0040090
doi: 10.1371/journal.pone.0040090
pubmed: 22768331
pmcid: 3388045
Breen ME, Laing EM, Hall DB, Hausman DB, Taylor RG, Isales CM, Ding KH, Pollock NK, Hamrick MW, Baile CA, Lewis RD (2011) 25-hydroxyvitamin D, insulin-like growth factor-I, and bone mineral accrual during growth. J Clin Endocrinol Metab 96(1):E89–E98. https://doi.org/10.1210/jc.2010-0595
doi: 10.1210/jc.2010-0595
pubmed: 20962027
Valtuena J, Gracia-Marco L, Vicente-Rodriguez G, Gonzalez-Gross M, Huybrechts I, Rey-Lopez JP, Mouratidou T, Sioen I, Mesana MI, Martinez AE, Widhalm K, Moreno LA, Group HS (2012) Vitamin D status and physical activity interact to improve bone mass in adolescents. The HELENA Study. Osteoporos Int 23(8):2227–2237. https://doi.org/10.1007/s00198-011-1884-7
doi: 10.1007/s00198-011-1884-7
pubmed: 22237816
Tanner JM (1986) Normal growth and techniques of growth assessment. Clin Endocrinol Metab 15(3):411–451. https://doi.org/10.1016/S0300-595X(86)80005-6
doi: 10.1016/S0300-595X(86)80005-6
pubmed: 3533329
Cole TJ, Bellizzi MC, Flegal KM, Dietz WH (2000) Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 320(7244):1240–1243. https://doi.org/10.1136/bmj.320.7244.1240
doi: 10.1136/bmj.320.7244.1240
pubmed: 10797032
pmcid: 27365
Cole TJ, Flegal KM, Nicholls D, Jackson AA (2007) Body mass index cut offs to define thinness in children and adolescents: international survey. BMJ 335(7612):194. https://doi.org/10.1136/bmj.39238.399444.55
doi: 10.1136/bmj.39238.399444.55
pubmed: 17591624
pmcid: 1934447
Jaworski M, Pludowski P (2013) Precision errors, least significant change, and monitoring time interval in pediatric measurements of bone mineral density, body composition, and mechanostat parameters by GE lunar prodigy. J Clin Densitom 16(4):562–569. https://doi.org/10.1016/j.jocd.2013.01.003
doi: 10.1016/j.jocd.2013.01.003
pubmed: 23452871
International Society for Clinical Densitometry (2019) 2019 ISCD Official Positions - Pediatric. https://www.iscd.org/official-positions/2019-iscd-official-positions-pediatric/ . Accessed 25/07 2019
Shepherd JA, Fan B, Lu Y, Wu XP, Wacker WK, Ergun DL, Levine MA (2012) A multinational study to develop universal standardization of whole-body bone density and composition using GE Healthcare Lunar and Hologic DXA systems. Journal of Bone and Mineral Research 27(10):2208–2216. https://doi.org/10.1002/jbmr.1654
doi: 10.1002/jbmr.1654
pubmed: 22623101
Corder K, Brage S, Mattocks C, Ness A, Riddoch C, Wareham NJ, Ekelund U (2007) Comparison of two methods to assess PAEE during six activities in children. Med Sci Sports Exerc 39(12):2180–2188. https://doi.org/10.1249/mss.0b013e318150dff8
doi: 10.1249/mss.0b013e318150dff8
pubmed: 18046189
Brage S, Brage N, Franks PW, Ekelund U, Wareham NJ (2005) Reliability and validity of the combined heart rate and movement sensor Actiheart. Eur J Clin Nutr 59(4):561–570. https://doi.org/10.1038/sj.ejcn.1602118
doi: 10.1038/sj.ejcn.1602118
pubmed: 15714212
Rowlands AV, Pilgrim EL, Eston RG (2008) Patterns of habitual activity across weekdays and weekend days in 9–11-year-old children. Prev Med 46(4):317–324. https://doi.org/10.1016/j.ypmed.2007.11.004
doi: 10.1016/j.ypmed.2007.11.004
pubmed: 18162187
Stegle O, Fallert SV, MacKay DJ, Brage S (2008) Gaussian process robust regression for noisy heart rate data. IEEE Trans Biomed Eng 55(9):2143–2151. https://doi.org/10.1109/TBME.2008.923118
doi: 10.1109/TBME.2008.923118
pubmed: 18713683
Lintu N, Tompuri T, Viitasalo A, Soininen S, Laitinen T, Savonen K, Lindi V, Lakka TA (2014) Cardiovascular fitness and haemodynamic responses to maximal cycle ergometer exercise test in children 6-8 years of age. J Sports Sci 32(7):652–659. https://doi.org/10.1080/02640414.2013.845681
doi: 10.1080/02640414.2013.845681
pubmed: 24279412
Brage S, Brage N, Franks PW, Ekelund U, Wong MY, Andersen LB, Froberg K, Wareham NJ (2004) Branched equation modeling of simultaneous accelerometry and heart rate monitoring improves estimate of directly measured physical activity energy expenditure. J Appl Physiol (1985) 96(1):343–351. https://doi.org/10.1152/japplphysiol.00703.2003
doi: 10.1152/japplphysiol.00703.2003
Collings PJ, Westgate K, Väistö J, Wijndaele K, Atkin AJ, Haapala EA, Lintu N, Laitinen T, Ekelund U, Brage S, Lakka TA (2017) Cross-sectional associations of objectively-measured physical activity and sedentary time with body composition and cardiorespiratory fitness in mid-childhood: the PANIC Study. Sports Med 47(4):769–780. https://doi.org/10.1007/s40279-016-0606-x
doi: 10.1007/s40279-016-0606-x
pubmed: 27558140
Janz KF, Rao S, Baumann HJ, Schultz JL (2003) Measuring children’s vertical ground reaction forces with accelerometry during walking, running, and jumping: The Iowa Bone Development Study. Pediatr Exerc Sci 15(1):34–43. https://doi.org/10.1123/pes.15.1.34
doi: 10.1123/pes.15.1.34
Corder K, Brage S, Wareham NJ, Ekelund U (2005) Comparison of PAEE from combined and separate heart rate and movement models in children. Med Sci Sports Exerc 37(10):1761–1767
doi: 10.1249/01.mss.0000176466.78408.cc
Tremblay MS, Carson V, Chaput JP (2016) Introduction to the Canadian 24-hour movement guidelines for children and youth: an integration of physical activity, sedentary behaviour, and sleep. Appl Physiol Nutr Metab 41(6 Suppl 3):iii–iv. https://doi.org/10.1139/apnm-2016-0203
doi: 10.1139/apnm-2016-0203
pubmed: 27306430
Brage S, Westgate K, Wijndaele K, Godinho J, Griffin S, Wareham N Evaluation of a method for minimizing diurnal information bias in objective sensor data. In: International Conference on Ambulatory Monitoring of Physical Activity and Movement, Massachusetts, USA, 2013.
Arundel P, Ahmed SF, Allgrove J, Bishop NJ, Burren CP, Jacobs B, Mughal MZ, Offiah AC, Shaw NJ, British P, Adolescent Bone G (2012) British Paediatric and Adolescent Bone Group’s position statement on vitamin D deficiency. BMJ 345:e8182. https://doi.org/10.1136/bmj.e8182
doi: 10.1136/bmj.e8182
pubmed: 23208261
Institute of Medicine (2011) Committee to review dietary reference intakes for vitamin, d and calcium. The National Academies Collection: Reports funded by National Institutes of Health. National Academies Press (US) National Academy of Sciences., Washington (DC). doi:10.17226/13050
Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM, Endocrine S (2011) Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96(7):1911–1930. https://doi.org/10.1210/jc.2011-0385
doi: 10.1210/jc.2011-0385
pubmed: 21646368
Alin A (2010) Multicollinearity. WIREs Comp Stats 2(3):370–374. https://doi.org/10.1002/wics.84
doi: 10.1002/wics.84
Zemel BS, Kalkwarf HJ, Gilsanz V, Lappe JM, Oberfield S, Shepherd JA, Frederick MM, Huang X, Lu M, Mahboubi S, Hangartner T, Winer KK (2011) Revised reference curves for bone mineral content and areal bone mineral density according to age and sex for black and non-black children: results of the bone mineral density in childhood study. J Clin Endocrinol Metab 96(10):3160–3169. https://doi.org/10.1210/jc.2011-1111
doi: 10.1210/jc.2011-1111
pubmed: 21917867
pmcid: 3200252
Roman-Vinas B, Chaput JP, Katzmarzyk PT, Fogelholm M, Lambert EV, Maher C, Maia J, Olds T, Onywera V, Sarmiento OL, Standage M, Tudor-Locke C, Tremblay MS, Group IR (2016) Proportion of children meeting recommendations for 24-hour movement guidelines and associations with adiposity in a 12-country study. Int J Behav Nutr Phys Act 13(1):123. https://doi.org/10.1186/s12966-016-0449-8
doi: 10.1186/s12966-016-0449-8
pubmed: 27887654
pmcid: 5123420
Migueles JH, Cadenas-Sanchez C, Tudor-Locke C, Löf M, Esteban-Cornejo I, Molina-Garcia P, Mora-Gonzalez J, Rodriguez-Ayllon M, Garcia-Marmol E, Ekelund U, Ortega FB (2019) Comparability of published cut-points for the assessment of physical activity: implications for data harmonization. Scand J Med Sci Sports 29(4):566–574. https://doi.org/10.1111/sms.13356
doi: 10.1111/sms.13356
pubmed: 30548545
Lamberg-Allardt C, Brustad M, Meyer HE, Steingrimsdottir L (2013) Vitamin D - a systematic literature review for the 5th edition of the Nordic Nutrition Recommendations. Food Nutr Res 57. doi: https://doi.org/10.3402/fnr.v57i0.22671
Soininen S, Eloranta AM, Lindi V, Venäläinen T, Zaproudina N, Mahonen A, Lakka TA (2016) Determinants of serum 25-hydroxyvitamin D concentration in Finnish children: the Physical Activity and Nutrition in Children (PANIC) study. Br J Nutr 115(6):1080–1091. https://doi.org/10.1017/S0007114515005292
doi: 10.1017/S0007114515005292
pubmed: 26836317
National Nutrition Council (2010) Report of Finnish experts of vitamin D.
National Nutrition Council (2014) Finnish nutrition recommendations – health from food (Suomalaiset ravitsemussuositukset–Terveyttä ruoasta). Helsinki, Juvenes Print
Elhakeem A, Heron J, Tobias JH, Lawlor DA (2020) Physical activity throughout adolescence and peak hip strength in young adults. JAMA Netw Open 3(8):e2013463. https://doi.org/10.1001/jamanetworkopen.2020.13463
doi: 10.1001/jamanetworkopen.2020.13463
pubmed: 32804215
pmcid: 7431998
Baquet G, Stratton G, Van Praagh E, Berthoin S (2007) Improving physical activity assessment in prepubertal children with high-frequency accelerometry monitoring: a methodological issue. Prev Med 44(2):143–147. https://doi.org/10.1016/j.ypmed.2006.10.004
doi: 10.1016/j.ypmed.2006.10.004
pubmed: 17157370
Winzenberg T, Powell S, Shaw KA, Jones G (2011) Effects of vitamin D supplementation on bone density in healthy children: systematic review and meta-analysis. Br Med J 342:c7254. https://doi.org/10.1136/bmj.c7254
doi: 10.1136/bmj.c7254
Kalkwarf HJ, Zemel BS, Gilsanz V, Lappe JM, Horlick M, Oberfield S, Mahboubi S, Fan B, Frederick MM, Winer K, Shepherd JA (2007) The bone mineral density in childhood study: bone mineral content and density according to age, sex, and race. J Clin Endocrinol Metab 92(6):2087–2099. https://doi.org/10.1210/jc.2006-2553
doi: 10.1210/jc.2006-2553
pubmed: 17311856
Soininen S, Sidoroff V, Lindi V, Mahonen A, Kröger L, Kröger H, Jääskeläinen J, Atalay M, Laaksonen DE, Laitinen T, Lakka TA (2018) Body fat mass, lean body mass and associated biomarkers as determinants of bone mineral density in children 6-8years of age - the Physical Activity and Nutrition in Children (PANIC) study. Bone 108:106–114. https://doi.org/10.1016/j.bone.2018.01.003
doi: 10.1016/j.bone.2018.01.003
pubmed: 29307776