Microbial community changes in a female rat model of Rett syndrome.

Animals Disease Models, Animal Fatty Acids, Volatile / metabolism Female Gastrointestinal Microbiome / physiology Methyl-CpG-Binding Protein 2 / genetics Mutation Rats Rett Syndrome / genetics

Journal

Progress in neuro-psychopharmacology & biological psychiatry
ISSN: 1878-4216
Titre abrégé: Prog Neuropsychopharmacol Biol Psychiatry
Pays: England
ID NLM: 8211617

Informations de publication

Date de publication:
13 07 2021
Historique:
received: 07 10 2020
accepted: 17 01 2021
pubmed: 7 2 2021
medline: 8 2 2022
entrez: 6 2 2021
Statut: ppublish

Résumé

Rett syndrome (RTT) is an X-linked neurodevelopmental disorder that is predominantly caused by alterations of the methyl-CpG-binding protein 2 (MECP2) gene. Disease severity and the presence of comorbidities such as gastrointestinal distress vary widely across affected individuals. The gut microbiome has been implicated in neurodevelopmental disorders such as Autism Spectrum Disorder (ASD) as a regulator of disease severity and gastrointestinal comorbidities. Although the gut microbiome has been previously characterized in humans with RTT compared to healthy controls, the impact of MECP2 mutation on the composition of the gut microbiome in animal models where the host and diet can be experimentally controlled remains to be elucidated. By evaluating the microbial community across postnatal development as behavioral symptoms appear and progress, we have identified microbial taxa that are differentially abundant across developmental timepoints in a zinc-finger nuclease rat model of RTT compared to WT. We have additionally identified p105 as a key translational timepoint. Lastly, we have demonstrated that fecal SCFA levels are not altered in RTT rats compared to WT rats across development. Overall, these results represent an important step in translational RTT research.

Identifiants

DOI: 10.1016/j.pnpbp.2021.110259 PMID: 33548354 PMC: PMC8724884
pubmed: 33548354
pii: S0278-5846(21)00018-X
doi: 10.1016/j.pnpbp.2021.110259
pmc: PMC8724884
mid: NIHMS1755824
pii:
doi:

Substances chimiques

Fatty Acids, Volatile 0
Methyl-CpG-Binding Protein 2 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

110259

Subventions

Organisme : NIAMS NIH HHS
ID : P30 AR050948
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL104101
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001417
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR003096
Pays : United States

Informations de copyright

Copyright © 2021. Published by Elsevier Inc.

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Auteurs

A Gallucci (A)

Graduate Program in Translational Biology Medicine and Health, Virginia Tech, Roanoke, VA 24014, United States of America; Animal and Poultry Sciences, Virginia Polytechnic and State University, Blacksburg, VA 24061, United States of America.

K C Patterson (KC)

Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, 1918 University Blvd., Birmingham, AL 35294, United States of America.

A R Weit (AR)

School of Neuroscience, Virginia Polytechnic and State University, Life Sciences Building Room 213, 970 Washington St. SW, Blacksburg, VA 24061, United States of America.

W J Van Der Pol (WJ)

Biomedical Informatics, Center for Clinical and Translational Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, United States of America.

L G Dubois (LG)

Duke Center for Genomic and Computational Biology, Duke University School of Medicine, Durham, NC 27708, United States of America.

A K Percy (AK)

Department of Pediatrics, Neurology, Neurobiology, Genetics, and Psychology, Civitan International Research Center, University of Alabama, Birmingham, AL 35233, United States of America.

C D Morrow (CD)

Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, 1918 University Blvd., Birmingham, AL 35294, United States of America.

S L Campbell (SL)

Animal and Poultry Sciences, Virginia Polytechnic and State University, Blacksburg, VA 24061, United States of America. Electronic address: susanc08@vt.edu.

M L Olsen (ML)

School of Neuroscience, Virginia Polytechnic and State University, Life Sciences Building Room 213, 970 Washington St. SW, Blacksburg, VA 24061, United States of America. Electronic address: molsen1@vt.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Microbial community changes in a female rat...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Microbial community changes in a female rat...
questionsmedicales.fr › Lipides › Acides gras › Acides gras volatils › Microbial community changes in a female rat...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Microbiome gastro-intestinal › Microbial community changes in a female rat...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines chromosomiques nonhistones › Protéine-2 de liaison au CpG méthylé › Microbial community changes in a female rat...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Microbial community changes in a female rat...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Microbial community changes in a female rat...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies génétiques congénitales › Maladies neurodégénératives héréditaires › Retard mental lié à l'X › Syndrome de Rett › Microbial community changes in a female rat...