Clinical and phytochemical studies of Plantago major in pressure ulcer treatment: A randomized controlled trial.

Humans Phytochemicals / therapeutic use Plantago Pressure Ulcer / drug therapy
Folk medicine HPLC Plantago major Pressure ulcer Quercetin Stroke

Journal

Complementary therapies in clinical practice
ISSN: 1873-6947
Titre abrégé: Complement Ther Clin Pract
Pays: England
ID NLM: 101225531

Informations de publication

Date de publication:
May 2021
Historique:
received: 12 09 2020
revised: 05 01 2021
accepted: 25 01 2021
pubmed: 7 2 2021
medline: 5 5 2021
entrez: 6 2 2021
Statut: ppublish

Résumé

Plantago major L. is used by local people to improve various wounds and lesions such as pressure ulcer. In this study, the therapeutic effects of P. major topical formulation on the stage 1 pressure ulcer in patients have been investigated. This randomized triple blind clinical trial study was performed on 130 patients. During the 14 days of study, each of the test and control groups was checked according to check list. Also the topical formulation was standardized by HPLC based on the amount of quercetin. The findings of this study indicated a significant difference in resolution of the damage between the test and control groups. Topical formulation was standardized by HPLC based on the quercetin (1.88 mg/100g) and no side effects associated with this topical formulation was found. The results confirmed the traditional use of P. major in resolution of the damage. CLINICAL TRIAL ID: (IRCT201609209014N117).

Sections du résumé

BACKGROUND BACKGROUND
Plantago major L. is used by local people to improve various wounds and lesions such as pressure ulcer. In this study, the therapeutic effects of P. major topical formulation on the stage 1 pressure ulcer in patients have been investigated.
MATERIALS AND METHODS METHODS
This randomized triple blind clinical trial study was performed on 130 patients. During the 14 days of study, each of the test and control groups was checked according to check list. Also the topical formulation was standardized by HPLC based on the amount of quercetin.
RESULTS RESULTS
The findings of this study indicated a significant difference in resolution of the damage between the test and control groups. Topical formulation was standardized by HPLC based on the quercetin (1.88 mg/100g) and no side effects associated with this topical formulation was found.
CONCLUSION CONCLUSIONS
The results confirmed the traditional use of P. major in resolution of the damage. CLINICAL TRIAL ID: (IRCT201609209014N117).

Identifiants

DOI: 10.1016/j.ctcp.2021.101325 PMID: 33548748
pubmed: 33548748
pii: S1744-3881(21)00024-4
doi: 10.1016/j.ctcp.2021.101325
pii:
doi:

Substances chimiques

Phytochemicals 0

Types de publication

Journal Article Randomized Controlled Trial

Langues

eng

Pagination

101325

Informations de copyright

Copyright © 2021. Published by Elsevier Ltd.

Auteurs

Masoud Ghiasian (M)

Department of Neurology, School of Medicine, Hamadan University of Medical Science, Hamadan, Iran.

Zahra Niroomandi (Z)

Department of Clinical Pharmacy, School of Pharmacy, Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.

Dara Dastan (D)

Department of Pharmacognosy, School of Pharmacy, Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.

Jalal Poorolajal (J)

Department of Epidemiology, School of Public Health, Hamadan University of Medical Science, Hamadan, Iran.

Fateme Zare (F)

Department of Neurology, School of Medicine, Hamadan University of Medical Science, Hamadan, Iran.

Sara Ataei (S)

Department of Clinical Pharmacy, School of Pharmacy, Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address: s.ataei@umsha.ac.ir.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Clinical and phytochemical studies of Plantago...
questionsmedicales.fr › Facteurs biologiques › Composés phytochimiques › Clinical and phytochemical studies of Plantago...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Lamiales › Plantaginaceae › Plantago › Clinical and phytochemical studies of Plantago...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Ulcère cutané › Escarre › Clinical and phytochemical studies of Plantago...