Role of oxidative stress in the dysfunction of the placental endothelial nitric oxide synthase in preeclampsia.
Endothelial nitric oxide synthase
Lipid peroxidation
Oxidative stress
Preeclampsia
Reactive oxygen species
S-glutathionylation
Journal
Redox biology
ISSN: 2213-2317
Titre abrégé: Redox Biol
Pays: Netherlands
ID NLM: 101605639
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
25
09
2020
revised:
30
12
2020
accepted:
05
01
2021
pubmed:
7
2
2021
medline:
22
6
2021
entrez:
6
2
2021
Statut:
ppublish
Résumé
Preeclampsia (PE) is a multifactorial pregnancy disease, characterized by new-onset gestational hypertension with (or without) proteinuria or end-organ failure, exclusively observed in humans. It is a leading cause of maternal morbidity affecting 3-7% of pregnant women worldwide. PE pathophysiology could result from abnormal placentation due to a defective trophoblastic invasion and an impaired remodeling of uterine spiral arteries, leading to a poor adaptation of utero-placental circulation. This would be associated with hypoxia/reoxygenation phenomena, oxygen gradient fluctuations, altered antioxidant capacity, oxidative stress, and reduced nitric oxide (NO) bioavailability. This results in part from the reaction of NO with the radical anion superoxide (O
Identifiants
pubmed: 33548859
pii: S2213-2317(21)00009-4
doi: 10.1016/j.redox.2021.101861
pmc: PMC7873691
pii:
doi:
Substances chimiques
Nitric Oxide
31C4KY9ESH
Nitric Oxide Synthase Type III
EC 1.14.13.39
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
101861Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.