A Critical Appraisal of the Effects of Anesthetics on Immune-system Modulation in Critically Ill Patients With COVID-19.

Anesthetics / administration & dosage COVID-19 / complications Critical Illness Humans Immune System / drug effects Inflammation / virology Pneumonia / virology Respiratory Distress Syndrome / virology
COVID-19 acute respiratory distress syndrome anesthetics inflammation multiple organ dysfunction syndrome

Journal

Clinical therapeutics
ISSN: 1879-114X
Titre abrégé: Clin Ther
Pays: United States
ID NLM: 7706726

Informations de publication

Date de publication:
03 2021
Historique:
received: 19 11 2020
revised: 26 12 2020
accepted: 02 01 2021
pubmed: 8 2 2021
medline: 11 5 2021
entrez: 7 2 2021
Statut: ppublish

Résumé

The aim of the present article was to briefly summarize current knowledge about the immunomodulatory effects of general anesthetics and the possible clinical effects of this immunomodulation in patients with COVID-19. The PubMed, Scopus, and Google Scholar databases were comprehensively searched for relevant studies. The novel coronavirus causes a wide spectrum of clinical manifestations, with a large absolute number of patients experiencing severe pneumonia and rapid progression to acute respiratory distress syndrome and multiple organ failure. In these patients, the equilibrium of the inflammatory response is a major determinant of survival. The impact of anesthetics on immune-system modulation may vary and includes both pro-inflammatory and anti-inflammatory effects. Inhibition of the development of severe inflammation and/or the enhancement of inflammation resolution by anesthetics may limit organ damage and improve outcomes in patients with COVID-19.

Identifiants

DOI: 10.1016/j.clinthera.2021.01.004 PMID: 33549310 PMC: PMC7833032
pubmed: 33549310
pii: S0149-2918(21)00008-4
doi: 10.1016/j.clinthera.2021.01.004
pmc: PMC7833032
pii:
doi:

Substances chimiques

Anesthetics 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

e57-e70

Subventions

Organisme : NIAID NIH HHS
ID : K23 AI143882
Pays : United States

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Disclosures The authors have indicated that they have no conflicts of interest with regard to the content of this article.

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Auteurs

Athanasios Chalkias (A)

Faculty of Medicine, Department of Anesthesiology, School of Health Sciences, University of Thessaly, Larisa, Greece. Electronic address: thanoschalkias@yahoo.gr.

Erin F Barreto (EF)

Department of Pharmacy, Mayo Clinic, Rochester, MN, USA; Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, USA.

Eleni Laou (E)

Faculty of Medicine, Department of Anesthesiology, School of Health Sciences, University of Thessaly, Larisa, Greece.

Konstantina Kolonia (K)

Faculty of Medicine, Department of Anesthesiology, School of Health Sciences, University of Thessaly, Larisa, Greece.

Marc H Scheetz (MH)

Department of Pharmacy Practice, Chicago College of Pharmacy, Midwestern University, Downers Grove, IL, USA; Pharmacometrics Center of Excellence, Chicago College of Pharmacy, Midwestern University, Downers Grove, IL, USA; Department of Pharmacology, College of Graduate Studies, Midwestern University, Downers Grove, IL, USA.

Konstantinos Gourgoulianis (K)

Faculty of Medicine, Department of Respiratory Medicine, School of Health Sciences, University of Thessaly, Larisa, Greece.

Ioannis Pantazopoulos (I)

Faculty of Medicine, Department of Emergency Medicine, School of Health Sciences, University of Thessaly, Larisa, Greece.

Theodoros Xanthos (T)

European University Cyprus, School of Medicine, Nicosia, Cyprus.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Dépresseurs du système nerveux central › Anesthésiques › A Critical Appraisal of the Effects of...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › A Critical Appraisal of the Effects of...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie grave › A Critical Appraisal of the Effects of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A Critical Appraisal of the Effects of...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › A Critical Appraisal of the Effects of...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › A Critical Appraisal of the Effects of...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › A Critical Appraisal of the Effects of...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Troubles respiratoires › Syndrome de détresse respiratoire de l'adulte › A Critical Appraisal of the Effects of...