General anaesthesia during infancy reduces white matter micro-organisation in developing rhesus monkeys.

Anesthesia, General / adverse effects Animals Animals, Newborn Brain / diagnostic imaging Diffusion Tensor Imaging / trends Female Macaca mulatta Male White Matter / diagnostic imaging
diffusion MRI general anaesthesia isoflurane ketamine neurotoxicity rhesus monkeys white matter

Journal

British journal of anaesthesia
ISSN: 1471-6771
Titre abrégé: Br J Anaesth
Pays: England
ID NLM: 0372541

Informations de publication

Date de publication:
04 2021
Historique:
received: 24 03 2020
revised: 04 12 2020
accepted: 24 12 2020
pubmed: 8 2 2021
medline: 1 4 2021
entrez: 7 2 2021
Statut: ppublish

Résumé

Non-human primates are commonly used in neuroimaging research for which general anaesthesia or sedation is typically required for data acquisition. In this analysis, the cumulative effects of exposure to ketamine, Telazol® (tiletamine and zolazepam), and the inhaled anaesthetic isoflurane on early brain development were evaluated in two independent cohorts of typically developing rhesus macaques. Diffusion MRI scans were analysed from 43 rhesus macaques (20 females and 23 males) at either 12 or 18 months of age from two separate primate colonies. Significant, widespread reductions in fractional anisotropy with corresponding increased axial, mean, and radial diffusivity were observed across the brain as a result of repeated anaesthesia exposures. These effects were dose dependent and remained after accounting for age and sex at time of exposure in a generalised linear model. Decreases of up to 40% in fractional anisotropy were detected in some brain regions. Multiple exposures to commonly used anaesthetics were associated with marked changes in white matter microstructure. This study is amongst the first to examine clinically relevant anaesthesia exposures on the developing primate brain. It will be important to examine if, or to what degree, the maturing brain can recover from these white matter changes.

Sections du résumé

BACKGROUND
Non-human primates are commonly used in neuroimaging research for which general anaesthesia or sedation is typically required for data acquisition. In this analysis, the cumulative effects of exposure to ketamine, Telazol® (tiletamine and zolazepam), and the inhaled anaesthetic isoflurane on early brain development were evaluated in two independent cohorts of typically developing rhesus macaques.
METHODS
Diffusion MRI scans were analysed from 43 rhesus macaques (20 females and 23 males) at either 12 or 18 months of age from two separate primate colonies.
RESULTS
Significant, widespread reductions in fractional anisotropy with corresponding increased axial, mean, and radial diffusivity were observed across the brain as a result of repeated anaesthesia exposures. These effects were dose dependent and remained after accounting for age and sex at time of exposure in a generalised linear model. Decreases of up to 40% in fractional anisotropy were detected in some brain regions.
CONCLUSIONS
Multiple exposures to commonly used anaesthetics were associated with marked changes in white matter microstructure. This study is amongst the first to examine clinically relevant anaesthesia exposures on the developing primate brain. It will be important to examine if, or to what degree, the maturing brain can recover from these white matter changes.

Identifiants

DOI: 10.1016/j.bja.2020.12.029 PMID: 33549320 PMC: PMC8132881
pubmed: 33549320
pii: S0007-0912(20)31051-5
doi: 10.1016/j.bja.2020.12.029
pmc: PMC8132881
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

845-853

Subventions

Organisme : NICHD NIH HHS
ID : U54 HD079124
Pays : United States
Organisme : NIH HHS
ID : P51 OD011132
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD103573
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH086633
Pays : United States
Organisme : NIMH NIH HHS
ID : P50 MH064065
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH070890
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD053000
Pays : United States
Organisme : NIMH NIH HHS
ID : P50 MH100031
Pays : United States
Organisme : NICHD NIH HHS
ID : R21 HD055255
Pays : United States
Organisme : NIMH NIH HHS
ID : P50 MH078105
Pays : United States
Organisme : NICHD NIH HHS
ID : P30 HD003110
Pays : United States
Organisme : NIBIB NIH HHS
ID : U54 EB005149
Pays : United States
Organisme : NICHD NIH HHS
ID : P30 HD003352
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2021 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.

Références

Neuroimage. 2013 Jan 1;64:156-66
pubmed: 22989623
Int Anesthesiol Clin. 2016 Winter;54(1):143-55
pubmed: 26655514
Brain Struct Funct. 2016 Mar;221(2):1189-203
pubmed: 25432771
Paediatr Anaesth. 2015 Mar;25(3):239-46
pubmed: 25557318
Anesthesiology. 2015 Nov;123(5):1084-92
pubmed: 26313293
Anesthesiology. 1993 Dec;79(6):1338-47; discussion 28A-29A
pubmed: 8267209
Science. 1989 Jun 16;244(4910):1360-2
pubmed: 2660263
Apoptosis. 2006 Sep;11(9):1603-15
pubmed: 16738805
Soc Neurosci. 2017 Feb;12(1):50-64
pubmed: 27295326
Anesthesiology. 2012 Sep;117(3):494-503
pubmed: 22801049
J Neurosci. 2013 Oct 9;33(41):16170-7
pubmed: 24107949
Toxicol Sci. 2007 Jul;98(1):145-58
pubmed: 17426105
Anesthesiology. 2017 Jan;126(1):74-84
pubmed: 27749311
Vet Anaesth Analg. 2010 Nov;37(6):501-10
pubmed: 21040374
Cereb Cortex. 2012 Jun;22(6):1294-308
pubmed: 21840845
Anesthesiology. 2010 Apr;112(4):834-41
pubmed: 20234312
Pediatrics. 2015 Jul;136(1):e1-12
pubmed: 26055844
Proc Natl Acad Sci U S A. 2017 Jan 3;114(1):148-153
pubmed: 27994134
Clin Perinatol. 2009 Jun;36(2):215-26, vii
pubmed: 19559316
Anesthesiology. 2012 Feb;116(2):372-84
pubmed: 22222480
Cereb Cortex. 2013 Jan;23(1):36-48
pubmed: 22275483
Front Neurosci. 2017 Feb 02;11:29
pubmed: 28210206
Int J Dev Neurosci. 2009 Nov;27(7):727-31
pubmed: 19580862
Anesth Analg. 1998 Nov;87(5):1186-93
pubmed: 9806706
Cell Physiol Biochem. 2018;47(4):1377-1388
pubmed: 29929189
Br J Anaesth. 2017 Sep 1;119(3):517-523
pubmed: 28575197
Neurotoxicol Teratol. 2011 Mar-Apr;33(2):220-30
pubmed: 21241795
Cereb Cortex. 2010 May;20(5):1053-63
pubmed: 19703936
Anesthesiology. 2007 Apr;106(4):746-53
pubmed: 17413912
Nature. 2007 May 3;447(7140):83-6
pubmed: 17476267
Anesth Analg. 2008 Jun;106(6):1712-4
pubmed: 18499599
Pediatr Res. 2010 Feb;67(2):117-27
pubmed: 20091937
J Neurosci. 2003 Feb 1;23(3):876-82
pubmed: 12574416
Neurosci Lett. 2013 Apr 29;541:58-62
pubmed: 23428509
Br J Pharmacol. 2005 Sep;146(2):189-97
pubmed: 15997239
Toxicol Lett. 2013 Jun 20;220(1):53-60
pubmed: 23566897
Paediatr Anaesth. 2018 Jun;28(6):520-527
pubmed: 29722100
Anesthesiology. 2014 Mar;120(3):626-38
pubmed: 24158051
Anesthesiology. 2018 Apr;128(4):840-853
pubmed: 29210706

Auteurs

Jeffrey T Young (JT)

Department of Psychiatry University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Roza M Vlasova (RM)

Department of Psychiatry University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address: roza_vlasova@med.unc.edu.

Brittany R Howell (BR)

Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.

Rebecca C Knickmeyer (RC)

Department of Psychiatry University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Elyse Morin (E)

Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.

Kaela I Kuitchoua (KI)

Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.

Gabriele R Lubach (GR)

Harlow Center for Biological Psychology, University of Wisconsin-Madison, Madison, WI, USA.

Jean Noel (J)

Department of Psychiatry University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Xiaoping Hu (X)

Department of Bioengineering, University of California, Riverside, CA, USA.

Yundi Shi (Y)

Department of Psychiatry University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Gibson Caudill (G)

Department of Psychiatry University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Andrew L Alexander (AL)

Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, Madison, WI, USA.

Marc Niethammer (M)

Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Merle G Paule (MG)

Division of Neurotoxicology, National Center for Toxicological Research, US Food & Drug Administration, Jefferson, AR, USA.

Christopher L Coe (CL)

Harlow Center for Biological Psychology, University of Wisconsin-Madison, Madison, WI, USA.

Mar Sanchez (M)

Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Emory University, Atlanta, GA, USA.

Martin Styner (M)

Department of Psychiatry University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Articles similaires

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Meal Timing and Anthropometric and Metabolic Outcomes: A Systematic Review and Meta-Analysis.

Hiu Yee Liu, Ashley A Eso, Nathan Cook et al.
1.00
Humans Meals Time Factors Female Adult

Classifications MeSH

questionsmedicales.fr › Anesthésie et analgésie › Anesthésie › Anesthésie générale › General anaesthesia during infancy reduces...
questionsmedicales.fr › Eucaryotes › Animaux › General anaesthesia during infancy reduces...
questionsmedicales.fr › Eucaryotes › Animaux › Groupes animaux › Animaux nouveau-nés › General anaesthesia during infancy reduces...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › General anaesthesia during infancy reduces...
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Imagerie par tenseur de diffusion › General anaesthesia during infancy reduces...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca › Macaca mulatta › General anaesthesia during infancy reduces...
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Substance blanche › General anaesthesia during infancy reduces...