Association between self-reported appetite and clinical outcomes of peritoneal dialysis patients: Findings from a low middle-income country.
appetite
patient-reported outcomes
peritoneal dialysis
peritoneal dialysis outcomes and practice patterns study (PDOPPS)
Journal
Nephrology (Carlton, Vic.)
ISSN: 1440-1797
Titre abrégé: Nephrology (Carlton)
Pays: Australia
ID NLM: 9615568
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
revised:
29
12
2020
received:
22
07
2020
accepted:
28
01
2021
pubmed:
8
2
2021
medline:
11
11
2021
entrez:
7
2
2021
Statut:
ppublish
Résumé
Patient-reported outcome measures (PROM) has gained international recognition as important predictors of clinical outcomes in peritoneal dialysis (PD). We sought to understand the associations between patient-reported appetite and clinical outcomes. In the Thailand Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS), 690 of 848 randomly selected PD patients from 22 facilities reported their appetite by using the short form (three items) of the Appetite and Diet Assessment Tool (ADAT), between 2016 and 2018. In this questionnaire, the patients rated their appetite as well as a change in appetite over time. Cox proportional hazards model regression was used to estimating associations between self-reported appetite and clinical outcomes, including mortality, haemodialysis (HD) transfer and peritonitis. Half of the PD patients reported a good appetite, whereas 34% and 16% reported fair and poor appetites, respectively. Poor appetite was more prevalent among female, diabetic, congestive heart failure, older age and patients who had worse nutritional indicators, including lower time-averaged serum albumin and serum creatinine concentrations, as well as a higher proportions of hypokalaemia and severe hypoalbuminemia (serum albumin <3 g/dl). After adjusting for age, sex, comorbidities, and PD vintage, poor appetite was associated with increased risks of peritonitis (adjusted hazard ratio [HR] 1.73, 95% confidence interval [CI] 1.14-2.62), HD transfer (adjusted HR 2.25, 95% CI 1.24-4.10) and all-cause mortality (adjusted HR 1.60, 95% CI 1.08-2.39) compared to patients with good appetite. Patient-reported poor appetite was independently associated with higher risks of peritonitis, HD transfer and all-cause mortality. This warrants further investigation to identify effective interventions.
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
454-462Subventions
Organisme : Baxter International Inc. (USA)
Organisme : Chulalongkorn University
Organisme : Japanese Society of Peritoneal Dialysis; Canadian Institute for Health Research (Canada)
Organisme : National Health and Medical Research Council (Australia)
Organisme : National Institute for Health Research (UK)
Organisme : National Institute of Diabetes and Digestive and Kidney Diseases, (USA)
Organisme : National Research Council of Thailand
ID : 156/2560
Organisme : Patient-Centered Outcomes Research Institute, (USA)
Organisme : Rachadaphiseksompot Endorcement Fund, Chulalongkorn University, Thailand
ID : CU_GRS_61_06_30_01
Organisme : Rachadaphiseksompot Endorsement Fund, Chulalongkorn University, Thailand
ID : CU-GRS_60_12_30_05
Organisme : Thailand Research Foundation
ID : IRG5780017
Organisme : The National Research Council of Thailand
ID : 6-2562
Organisme : the National Science and Technology Development Agency (NSTDA), Thailand
Informations de copyright
© 2021 Asian Pacific Society of Nephrology.
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