Acid-Sensing Ion Channels: Focus on Physiological and Some Pathological Roles in the Brain.
None
Journal
Current neuropharmacology
ISSN: 1875-6190
Titre abrégé: Curr Neuropharmacol
Pays: United Arab Emirates
ID NLM: 101157239
Informations de publication
Date de publication:
2021
2021
Historique:
received:
13
08
2020
revised:
29
11
2020
accepted:
14
01
2021
pubmed:
9
2
2021
medline:
26
11
2021
entrez:
8
2
2021
Statut:
ppublish
Résumé
Acid-sensing ion channels (ASICs) are Na+-permeable ion channels activated by protons and predominantly expressed in the nervous system. ASICs act as pH sensors leading to neuronal excitation. At least eight different ASIC subunits (including ASIC1a, ASIC1b, ASIC2a, ASIC2b, ASIC3, ASIC4, ASIC5) are encoded by five genes (ASIC1-ASIC5). Functional ASICs assembled in the plasma membrane are homo- or heteromeric trimers. ASIC1a-containing trimers are of particular interest as, in addition to sodium ions, they also conduct calcium ions and thus can trigger or regulate multiple cellular processes. ASICs are widely but differentially expressed in the central and peripheral nervous systems. In the mammalian brain, a majority of neurons express at least one ASIC subunit. Several recent reviews have summarized findings of the role of ASICs in the peripheral nervous system, particularly in nociception and proprioception, and the structure-function relationship of ASICs. However, there is little coverage on recent findings regarding the role of ASICs in the brain. Here we review and discuss evidence regarding the roles of ASICs: (i) as postsynaptic receptors activated by protons coreleased with glutamate at glutamatergic synapses; (ii) as modulators of synaptic transmission at glutamatergic synapses and GABAergic synapses; (iii) in synaptic plasticity, memory and learning; (iv) in some pathologies such as epilepsy, mood disorders and Alzheimer's disease.
Identifiants
pubmed: 33550975
pii: CN-EPUB-113630
doi: 10.2174/1570159X19666210125151824
pmc: PMC8762183
doi:
Substances chimiques
ASIC5 protein, human
0
Acid Sensing Ion Channels
0
Sodium
9NEZ333N27
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1570-1589Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
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