Vitamin-related phenotypic adaptation to exposomal factors: The folate-vitamin D-exposome triad.
Adaptation
Epigenetics
Evolution
Exposome
Folic acid
Phenome
Vitamin D
Journal
Molecular aspects of medicine
ISSN: 1872-9452
Titre abrégé: Mol Aspects Med
Pays: England
ID NLM: 7603128
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
received:
22
10
2020
revised:
02
01
2021
accepted:
25
01
2021
pubmed:
9
2
2021
medline:
24
8
2022
entrez:
8
2
2021
Statut:
ppublish
Résumé
The biological role of two key vitamins, folic acid and vitamin D is so fundamental to life processes, it follows that their UV sensitivity, dietary abundance (both key exposomal factors) and variability in dependent genes will modify their functional efficacy, particularly in the context of maintaining the integrity and function of genome and epigenome. This article therefore examines folate and vitamin D-related phenotypic adaptation to environmental factors which vary across the human life cycle as well as over an evolutionary time-scale. Molecular mechanisms, key nutrigenomic factors, phenotypic maladaptation and evolutionary models are discussed.
Identifiants
pubmed: 33551238
pii: S0098-2997(21)00004-2
doi: 10.1016/j.mam.2021.100944
pii:
doi:
Substances chimiques
Vitamins
0
Vitamin D
1406-16-2
Folic Acid
935E97BOY8
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
100944Informations de copyright
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