Case Report: Primary Hypothyroidism Associated With Lutetium 177-DOTATATE Therapy for Metastatic Paraganglioma.
Adult
Asymptomatic Diseases
Hashimoto Disease
/ complications
Humans
Hypothyroidism
/ chemically induced
Male
Neoplasm Metastasis
/ radiotherapy
Octreotide
/ adverse effects
Organometallic Compounds
/ adverse effects
Paraganglioma
/ complications
Positron Emission Tomography Computed Tomography
/ methods
Radiopharmaceuticals
/ adverse effects
Succinate Dehydrogenase
/ metabolism
Thyroid Gland
/ diagnostic imaging
Thyroxine
/ therapeutic use
Treatment Outcome
DOTATATE
Lutathera
hypothyroidism
paraganglioma
peptide receptor radionuclide therapy
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2020
2020
Historique:
received:
24
07
2020
accepted:
30
11
2020
entrez:
8
2
2021
pubmed:
9
2
2021
medline:
28
5
2021
Statut:
epublish
Résumé
Lutetium 177 ( A 29-year-old male with We report, for the first time, a patient with asymptomatic primary hyperthyroidism who rapidly developed symptomatic primary hypothyroidism 1 month after Thyroid dysfunction can be associated with PRRT. Thyroid uptake patterns on pre-treatment diagnostic somatostatin analog scans might predict individual susceptibility to PRRT-associated TFT disruption. Therefore, periodic evaluation of TFTs should be considered in patients receiving PRRT.
Sections du résumé
Background
Lutetium 177 (
Case Description
A 29-year-old male with
Summary
We report, for the first time, a patient with asymptomatic primary hyperthyroidism who rapidly developed symptomatic primary hypothyroidism 1 month after
Conclusions
Thyroid dysfunction can be associated with PRRT. Thyroid uptake patterns on pre-treatment diagnostic somatostatin analog scans might predict individual susceptibility to PRRT-associated TFT disruption. Therefore, periodic evaluation of TFTs should be considered in patients receiving PRRT.
Identifiants
pubmed: 33551992
doi: 10.3389/fendo.2020.587065
pmc: PMC7859638
doi:
Substances chimiques
Organometallic Compounds
0
Radiopharmaceuticals
0
gallium Ga 68 dotatate
9L17Y0H71P
lutetium Lu 177 dotatate
AE221IM3BB
SDHB protein, human
EC 1.3.5.1
Succinate Dehydrogenase
EC 1.3.99.1
Thyroxine
Q51BO43MG4
Octreotide
RWM8CCW8GP
Banques de données
ClinicalTrials.gov
['NCT03206060']
Types de publication
Case Reports
Clinical Trial
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
587065Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA BC011789
Pays : United States
Informations de copyright
Copyright © 2021 Gubbi, Al-Jundi, Del Rivero, Jha, Knue, Zou, Turkbey, Carrasquillo, Lin, Pacak, Klubo-Gwiezdzinska and Lin.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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