Evolution of bacteria in the human gut in response to changing environments: An invisible player in the game of health.


Journal

Computational and structural biotechnology journal
ISSN: 2001-0370
Titre abrégé: Comput Struct Biotechnol J
Pays: Netherlands
ID NLM: 101585369

Informations de publication

Date de publication:
2021
Historique:
received: 31 08 2020
revised: 07 01 2021
accepted: 08 01 2021
entrez: 8 2 2021
pubmed: 9 2 2021
medline: 9 2 2021
Statut: epublish

Résumé

Several factors in Western society, including widespread use of antibiotics, chronic inflammation, and loss of complex eukaryotic symbionts such as helminths, have a dramatic impact on the ecosystem of the gut, affecting the microbiota hosted there. In addition, reductions in dietary fiber are profoundly impactful on the microbiota, causing extensive destruction of the niche space that supports the normally diverse microbial community in the gut. Abundant evidence now supports the view that, following dramatic alterations in the gut ecosystem, microorganisms undergo rapid change via Darwinian evolution. Such evolutionary change creates functionally distinct bacteria that may potentially have properties of pathogens but yet are difficult to distinguish from their benign predecessors.

Identifiants

pubmed: 33552447
doi: 10.1016/j.csbj.2021.01.007
pii: S2001-0370(21)00011-8
pmc: PMC7829112
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

752-758

Informations de copyright

© 2021 The Authors.

Déclaration de conflit d'intérêts

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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Auteurs

Aarushi Venkatakrishnan (A)

Department of Surgery, Duke University School of Medicine, Durham, NC, USA.

Zoie E Holzknecht (ZE)

Department of Surgery, Duke University School of Medicine, Durham, NC, USA.

Rob Holzknecht (R)

Department of Surgery, Duke University School of Medicine, Durham, NC, USA.

Dawn E Bowles (DE)

Department of Surgery, Duke University School of Medicine, Durham, NC, USA.

Sanet H Kotzé (SH)

Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Stellenbosch, Cape Town 8000, South Africa.

Jennifer L Modliszewski (JL)

Genomic Analysis and Bioinformatics Shared Resource, Duke Center for Genomic and Computational Biology, Duke University School of Medicine, Durham, NC, USA.

William Parker (W)

Department of Surgery, Duke University School of Medicine, Durham, NC, USA.

Classifications MeSH