Sensitivity of Awaji Criteria and Revised El Escorial Criteria in the Diagnosis of Amyotrophic Lateral Sclerosis (ALS) at First Visit in a Tunisian Cohort.
Journal
Neurology research international
ISSN: 2090-1852
Titre abrégé: Neurol Res Int
Pays: United States
ID NLM: 101543314
Informations de publication
Date de publication:
2021
2021
Historique:
received:
28
09
2020
revised:
10
01
2021
accepted:
16
01
2021
entrez:
8
2
2021
pubmed:
9
2
2021
medline:
9
2
2021
Statut:
epublish
Résumé
Amyotrophic lateral sclerosis (ALS) is a fatal disease whose diagnosis and early management can improve survival. The most used diagnostic criteria are the revised El Escorial criteria (rEEC) and Awaji criteria (AC). The comparison of their sensitivities showed contradictory results. Our study aimed to compare the sensitivities of these two criteria in the diagnosis of definite ALS, at first visit, in a Tunisian hospital cohort. This was a retrospective study including 173 patients diagnosed with ALS at the Department of Neurology of the Razi Hospital between January 2003 and April 2018.After studying the clinical features of the disease in our study population,each patient was categorized according to the rEEC and AC based on data collected in his medical record during his first visit to our department. Then, we compared the sensitivities of these two criteria in the diagnosis of definite ALS. Our Tunisian cohort was characterized by a slower disease progression. The sensitivity of the AC (69.4%) was significantly higher than that of the rEEC (40.5%) ( Our study demonstrated that patients in AC are more sensitive than rEEC in the early diagnosis of ALS in our Tunisian cohort. However, this superiority is gradually reduced during the evolution of the disease.
Sections du résumé
BACKGROUND
BACKGROUND
Amyotrophic lateral sclerosis (ALS) is a fatal disease whose diagnosis and early management can improve survival. The most used diagnostic criteria are the revised El Escorial criteria (rEEC) and Awaji criteria (AC). The comparison of their sensitivities showed contradictory results. Our study aimed to compare the sensitivities of these two criteria in the diagnosis of definite ALS, at first visit, in a Tunisian hospital cohort.
MATERIALS AND METHODS
METHODS
This was a retrospective study including 173 patients diagnosed with ALS at the Department of Neurology of the Razi Hospital between January 2003 and April 2018.After studying the clinical features of the disease in our study population,each patient was categorized according to the rEEC and AC based on data collected in his medical record during his first visit to our department. Then, we compared the sensitivities of these two criteria in the diagnosis of definite ALS.
RESULTS
RESULTS
Our Tunisian cohort was characterized by a slower disease progression. The sensitivity of the AC (69.4%) was significantly higher than that of the rEEC (40.5%) (
CONCLUSION
CONCLUSIONS
Our study demonstrated that patients in AC are more sensitive than rEEC in the early diagnosis of ALS in our Tunisian cohort. However, this superiority is gradually reduced during the evolution of the disease.
Identifiants
pubmed: 33552600
doi: 10.1155/2021/8841281
pmc: PMC7847325
doi:
Types de publication
Journal Article
Langues
eng
Pagination
8841281Informations de copyright
Copyright © 2021 Bademain Jean Fabrice Ido et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
Références
PLoS One. 2017 Mar 1;12(3):e0171522
pubmed: 28249004
J Neurol Neurosurg Psychiatry. 1990 Dec;53(12):1043-5
pubmed: 2292694
J Neurol Sci. 1994 Jul;124 Suppl:96-107
pubmed: 7807156
PLoS One. 2015 Jul 14;10(7):e0131965
pubmed: 26172548
Clin Neurophysiol. 2008 Mar;119(3):497-503
pubmed: 18164242
J Neurol Neurosurg Psychiatry. 2019 Jan;90(1):20-29
pubmed: 30242088
Med Res Rev. 2019 Mar;39(2):733-748
pubmed: 30101496
J Neurol. 2012 Sep;259(9):1788-92
pubmed: 22258480
Arch Neurol. 2012 Nov;69(11):1410-6
pubmed: 22892641
Amyotroph Lateral Scler. 2009 Oct-Dec;10(5-6):310-23
pubmed: 19922118
Amyotroph Lateral Scler Frontotemporal Degener. 2014 Jun;15(3-4):257-61
pubmed: 24575803
Clin Neurophysiol. 2011 Mar;122(3):623-628
pubmed: 20810308
Amyotroph Lateral Scler Frontotemporal Degener. 2020 Nov;21(7-8):635-637
pubmed: 32501131
Eur J Epidemiol. 2016 Mar;31(3):229-45
pubmed: 26458931
Amyotroph Lateral Scler Other Motor Neuron Disord. 2000 Dec;1(5):293-9
pubmed: 11464847
Amyotroph Lateral Scler Frontotemporal Degener. 2015;16(5-6):291-2
pubmed: 26121170
Clin Neurophysiol. 2018 Dec;129(12):2650-2657
pubmed: 30292684
Clin Neurophysiol. 2012 Feb;123(2):382-5
pubmed: 21764635
Rev Neurol (Paris). 2006 Jun;162 Spec No 2:4S25-4S28
pubmed: 17128086
Clin Neurophysiol. 2012 Feb;123(2):217-8
pubmed: 21764633
Muscle Nerve. 2012 Feb;45(2):175-82
pubmed: 22246871
Orphanet J Rare Dis. 2009 Feb 03;4:3
pubmed: 19192301
Muscle Nerve. 2015 Jun;51(6):822-9
pubmed: 25597926
Clin Neurophysiol. 2016 Jul;127(7):2684-91
pubmed: 27212114
Muscle Nerve. 2011 Apr;43(4):461-3
pubmed: 21404284
Amyotroph Lateral Scler Frontotemporal Degener. 2020 Feb;21(1-2):131-139
pubmed: 31858811
Amyotroph Lateral Scler. 2009 Feb;10(1):53-7
pubmed: 18985466
Rev Neurol (Paris). 1984;140(3):202-6
pubmed: 6729330
Arch Neurol. 2000 Aug;57(8):1171-6
pubmed: 10927797
Neurology. 1958 Mar;8(3):175-80
pubmed: 13517482
Clin Neurophysiol. 2011 Feb;122(2):414-22
pubmed: 20659815
Clin Neurophysiol. 2020 Aug;131(8):1975-1978
pubmed: 32387049