Non-Toxic Virucidal Macromolecules Show High Efficacy Against Influenza Virus Ex Vivo and In Vivo.
3’SLN
6’SLN
Influenza
antivirals
virucidal
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
18
03
2020
revised:
07
09
2020
entrez:
8
2
2021
pubmed:
9
2
2021
medline:
9
2
2021
Statut:
epublish
Résumé
Influenza is one of the most widespread viral infections worldwide and represents a major public health problem. The risk that one of the next pandemics is caused by an influenza strain is high. It is important to develop broad-spectrum influenza antivirals to be ready for any possible vaccine shortcomings. Anti-influenza drugs are available but they are far from ideal. Arguably, an ideal antiviral should target conserved viral domains and be virucidal, that is, irreversibly inhibit viral infectivity. Here, a new class of broad-spectrum anti-influenza macromolecules is described that meets these criteria and display exceedingly low toxicity. These compounds are based on a cyclodextrin core modified on its primary face with long hydrophobic linkers terminated either in 6'sialyl-
Identifiants
pubmed: 33552848
doi: 10.1002/advs.202001012
pii: ADVS2213
pmc: PMC7856883
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2001012Subventions
Organisme : NIAID NIH HHS
ID : HHSN272201700041I
Pays : United States
Informations de copyright
© 2020 The Authors. Advanced Science published by Wiley‐VCH GmbH.
Déclaration de conflit d'intérêts
O.K., V.C., C.T., and F.S. are inventors on patent number EP18192559.5. All the other authors declare no conflict of interest.
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