Multispectral optoacoustic tomography of peripheral arterial disease based on muscle hemoglobin gradients-a pilot clinical study.
Medical imaging
peripheral arterial disease
photoacoustic techniques
Journal
Annals of translational medicine
ISSN: 2305-5839
Titre abrégé: Ann Transl Med
Pays: China
ID NLM: 101617978
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
entrez:
8
2
2021
pubmed:
9
2
2021
medline:
9
2
2021
Statut:
ppublish
Résumé
Current imaging assessment of peripheral artery disease (PAD) relies on anatomical cross-sectional visualizations of the affected arteries. Multispectral optoacoustic tomography (MSOT) is a novel molecular imaging technique that provides direct and label-free visualizations of soft tissue perfusion and oxygenation. MSOT was prospectively assessed in a pilot trial in healthy volunteers (group n Calf measurements in healthy volunteers revealed distinct dynamics for HbO Clinical MSOT allows for non-invasive, label-free and real-time imaging of muscle oxygenation in health and disease with implications for diagnostics and therapy assessment in PAD.
Sections du résumé
BACKGROUND
BACKGROUND
Current imaging assessment of peripheral artery disease (PAD) relies on anatomical cross-sectional visualizations of the affected arteries. Multispectral optoacoustic tomography (MSOT) is a novel molecular imaging technique that provides direct and label-free visualizations of soft tissue perfusion and oxygenation.
METHODS
METHODS
MSOT was prospectively assessed in a pilot trial in healthy volunteers (group n
RESULTS
RESULTS
Calf measurements in healthy volunteers revealed distinct dynamics for HbO
CONCLUSIONS
CONCLUSIONS
Clinical MSOT allows for non-invasive, label-free and real-time imaging of muscle oxygenation in health and disease with implications for diagnostics and therapy assessment in PAD.
Identifiants
pubmed: 33553329
doi: 10.21037/atm-20-3321
pii: atm-09-01-36
pmc: PMC7859778
doi:
Types de publication
Journal Article
Langues
eng
Pagination
36Informations de copyright
2021 Annals of Translational Medicine. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/atm-20-3321). Prof. VN reports to be a stock owner of iThera Medical GmbH, Munich, Germany. The other authors have no conflicts of interest to declare.
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