Topoisomerase I prevents transcription-replication conflicts at transcription termination sites.
R-loops
Transcription-replication conflict
chromosome breaks
topoisomerase I
Journal
Molecular & cellular oncology
ISSN: 2372-3556
Titre abrégé: Mol Cell Oncol
Pays: United States
ID NLM: 101642411
Informations de publication
Date de publication:
07 Dec 2020
07 Dec 2020
Historique:
entrez:
8
2
2021
pubmed:
9
2
2021
medline:
9
2
2021
Statut:
epublish
Résumé
R-loops have both positive and negative impacts on chromosome functions. To identify toxic R-loops, we mapped RNA:DNA hybrids, markers of replication fork stalling and DNA double-strand breaks along the human genome. This analysis indicates that transient replication fork pausing occurs at the transcription termination sites of highly expressed genes enriched in R-loops and prevents head-on conflicts with transcription, in a topoisomerase I-dependent manner.
Identifiants
pubmed: 33553603
doi: 10.1080/23723556.2020.1843951
pii: 1843951
pmc: PMC7849740
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1843951Informations de copyright
© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.
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