A flow cytometric assay for the quantification of MSC lysis by peripheral blood mononucleated cells.
Absolute count
Apoptosis
Cytotoxicity
Graft versus host disease
Mesenchymal stromal cell
Journal
Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
23
10
2020
revised:
31
12
2020
accepted:
14
01
2021
entrez:
8
2
2021
pubmed:
9
2
2021
medline:
9
2
2021
Statut:
epublish
Résumé
Mesenchymal stromal cells (MSC) are attractive candidates for the treatment of acute graft versus host disease (aGvHD) or autoimmune disorders. However, mechanisms of MSC recognition remain unclear and there are evidences that MSC are not totally immunoprivileged. Data suggest that MSC undergo apoptosis after infusion in presence of cytotoxic cells and their death could drive immunosuppression. In GvHD patients, that activity was associated with clinical response. It is mandatory to develop an
Identifiants
pubmed: 33553772
doi: 10.1016/j.heliyon.2021.e06036
pii: S2405-8440(21)00141-9
pmc: PMC7856420
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e06036Informations de copyright
© 2021 The Author(s).
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Blood. 2003 May 1;101(9):3722-9
pubmed: 12506037
Stem Cells Dev. 2013 Jun 15;22(12):1789-801
pubmed: 23339531
Blood. 2002 May 15;99(10):3838-43
pubmed: 11986244
Stem Cell Res Ther. 2018 Jan 16;9(1):10
pubmed: 29338788
Cytotherapy. 2006;8(4):315-7
pubmed: 16923606
Nat Biotechnol. 2014 Mar;32(3):252-60
pubmed: 24561556
Stem Cells. 2009 Jun;27(6):1421-32
pubmed: 19489103
Blood. 2005 Dec 15;106(13):4057-65
pubmed: 16118325
Stem Cells. 2009 Nov;27(11):2865-74
pubmed: 19750539
Sci Transl Med. 2017 Nov 15;9(416):
pubmed: 29141887
Scand J Immunol. 2003 Jan;57(1):11-20
pubmed: 12542793
Blood. 2006 Feb 15;107(4):1484-90
pubmed: 16239427
Lancet. 2004 May 1;363(9419):1439-41
pubmed: 15121408
Blood Cells Mol Dis. 2012 Oct 15-Dec 15;49(3-4):159-65
pubmed: 22818859
Stem Cells. 2006 Jan;24(1):74-85
pubmed: 16099998
Lancet. 2008 May 10;371(9624):1579-86
pubmed: 18468541
Exp Hematol. 2002 Jan;30(1):42-8
pubmed: 11823036
Science. 1999 Apr 2;284(5411):143-7
pubmed: 10102814
Cytotherapy. 2011 Mar;13(3):269-78
pubmed: 20942778
J Cell Mol Med. 2012 Sep;16(9):2094-103
pubmed: 22151542
Cell Stem Cell. 2009 Jul 2;5(1):54-63
pubmed: 19570514
Lancet. 2016 Sep 24;388(10051):1251-2
pubmed: 27477895
Curr Opin Organ Transplant. 2015 Feb;20(1):72-8
pubmed: 25563994
PLoS One. 2009 Sep 22;4(9):e7119
pubmed: 19771171
J R Soc Interface. 2010 Dec 6;7 Suppl 6:S689-706
pubmed: 20739312
Cell Transplant. 2011;20(10):1547-59
pubmed: 21396164
Transplantation. 2007 Mar 27;83(6):783-90
pubmed: 17414713
Stem Cell Res Ther. 2017 Jan 24;8(1):14
pubmed: 28115021
Sci Rep. 2018 Jun 18;8(1):9321
pubmed: 29915318