Carbon nanomaterials for cardiovascular theranostics: Promises and challenges.
Biosensors
Carbon nanomaterials
Cardiac tissue engineering
Cardiovascular disease
Drug delivery
Immunomodulation
Journal
Bioactive materials
ISSN: 2452-199X
Titre abrégé: Bioact Mater
Pays: China
ID NLM: 101685294
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
08
09
2020
revised:
15
12
2020
accepted:
31
12
2020
entrez:
8
2
2021
pubmed:
9
2
2021
medline:
9
2
2021
Statut:
epublish
Résumé
Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Heart attack and stroke cause irreversible tissue damage. The currently available treatment options are limited to "damage-control" rather than tissue repair. The recent advances in nanomaterials have offered novel approaches to restore tissue function after injury. In particular, carbon nanomaterials (CNMs) have shown significant promise to bridge the gap in clinical translation of biomaterial based therapies. This family of carbon allotropes (including graphenes, carbon nanotubes and fullerenes) have unique physiochemical properties, including exceptional mechanical strength, electrical conductivity, chemical behaviour, thermal stability and optical properties. These intrinsic properties make CNMs ideal materials for use in cardiovascular theranostics. This review is focused on recent efforts in the diagnosis and treatment of heart diseases using graphenes and carbon nanotubes. The first section introduces currently available derivatives of graphenes and carbon nanotubes and discusses some of the key characteristics of these materials. The second section covers their application in drug delivery, biosensors, tissue engineering and immunomodulation with a focus on cardiovascular applications. The final section discusses current shortcomings and limitations of CNMs in cardiovascular applications and reviews ongoing efforts to address these concerns and to bring CNMs from bench to bedside.
Identifiants
pubmed: 33553814
doi: 10.1016/j.bioactmat.2020.12.030
pii: S2452-199X(21)00002-5
pmc: PMC7829079
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
2261-2280Informations de copyright
© 2021 [The Author/The Authors].
Déclaration de conflit d'intérêts
Authors declare no conflict of interest.
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