Anti-V2 antibodies virus vulnerability revealed by envelope V1 deletion in HIV vaccine candidates.

Immunology molecular structure virology

Journal

iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038

Informations de publication

Date de publication:
19 Feb 2021
Historique:
received: 14 09 2020
revised: 23 11 2020
accepted: 06 01 2021
entrez: 8 2 2021
pubmed: 9 2 2021
medline: 9 2 2021
Statut: epublish

Résumé

The efficacy of ALVAC-based HIV and SIV vaccines in humans and macaques correlates with antibodies to envelope variable region 2 (V2). We show here that vaccine-induced antibodies to SIV variable region 1 (V1) inhibit anti-V2 antibody-mediated cytotoxicity and reverse their ability to block V2 peptide interaction with the α

Identifiants

DOI: 10.1016/j.isci.2021.102047 PMID: 33554060 PMC: PMC7847973
pubmed: 33554060
doi: 10.1016/j.isci.2021.102047
pii: S2589-0042(21)00015-8
pmc: PMC7847973
doi:

Types de publication

Journal Article

Langues

eng

Pagination

102047

Subventions

Organisme : NIAID NIH HHS
ID : T32 AI007392
Pays : United States
Organisme : NIDA NIH HHS
ID : DP1 DA036478
Pays : United States
Organisme : CCR NIH HHS
ID : HHSN261200800001C
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261200800001E
Pays : United States
Organisme : NIH HHS
ID : P51 OD011104
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI084119
Pays : United States

Informations de copyright

© 2021.

Déclaration de conflit d'intérêts

The US Government has filed a patent on the V1-deleted immunogens with G.F., T.C., I.S.d.C., M.B.-F., M. Bissa., and R.M.A as inventors.

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Auteurs

Isabela Silva de Castro (I)

Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA.

Giacomo Gorini (G)

Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA.

Rosemarie Mason (R)

ImmunoTechnology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Jason Gorman (J)

Structural Biology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Massimiliano Bissa (M)

Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA.

Mohammad A Rahman (MA)

Immune Biology of Retroviral Infection Section, National Cancer Institute, Bethesda, MD 20892, USA.

Anush Arakelyan (A)

Section on Intercellular Interactions, Eunice Kennedy-Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

Irene Kalisz (I)

Advanced Bioscience Laboratories, Rockville, MD 20850, USA.

Stephen Whitney (S)

Advanced Bioscience Laboratories, Rockville, MD 20850, USA.

Manuel Becerra-Flores (M)

New York University School of Medicine, NYU Langone Health, New York, NY 10016, USA.

Eric Ni (E)

New York University School of Medicine, NYU Langone Health, New York, NY 10016, USA.

Kristina Peachman (K)

Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Hung V Trinh (HV)

Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Michael Read (M)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Mei-Hue Liu (MH)

Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Donald Van Ryk (D)

Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Dominic Paquin-Proulx (D)

Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Zhanna Shubin (Z)

Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Marina Tuyishime (M)

Division of Surgical Sciences, Duke University School of Medicine, Durham, NC 27701, USA.

Jennifer Peele (J)

Division of Surgical Sciences, Duke University School of Medicine, Durham, NC 27701, USA.

Mohammed S Ahmadi (MS)

Structural Biology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Raffaello Verardi (R)

Structural Biology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Juliane Hill (J)

ImmunoTechnology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Margaret Beddall (M)

ImmunoTechnology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Richard Nguyen (R)

ImmunoTechnology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

James D Stamos (JD)

Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA.

Dai Fujikawa (D)

Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA.

Susie Min (S)

Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Luca Schifanella (L)

Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA.

Monica Vaccari (M)

Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA.

Veronica Galli (V)

Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA.

Melvin N Doster (MN)

Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA.

Namal P M Liyanage (NPM)

Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA.

Sarkis Sarkis (S)

Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA.

Francesca Caccuri (F)

Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA.

Celia LaBranche (C)

Division of Surgical Sciences, Duke University School of Medicine, Durham, NC 27701, USA.

David C Montefiori (DC)

Division of Surgical Sciences, Duke University School of Medicine, Durham, NC 27701, USA.

Georgia D Tomaras (GD)

Duke Human Vaccine Institute, Duke University, Durham, NC 27701, USA.

Xiaoying Shen (X)

Duke Human Vaccine Institute, Duke University, Durham, NC 27701, USA.

Margherita Rosati (M)

Human Retrovirus Section, National Cancer Institute, Frederick, MD 21702, USA.

Barbara K Felber (BK)

Human Retrovirus Pathogenesis Section, National Cancer Institute, Frederick, MD 21702, USA.

George N Pavlakis (GN)

Human Retrovirus Section, National Cancer Institute, Frederick, MD 21702, USA.

David J Venzon (DJ)

Biostatistics and Data Management Section, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

William Magnanelli (W)

AIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory, Frederick, MD 21704, USA.

Matthew Breed (M)

AIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory, Frederick, MD 21704, USA.

Josh Kramer (J)

AIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory, Frederick, MD 21704, USA.

Brandon F Keele (BF)

AIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory, Frederick, MD 21704, USA.

Michael A Eller (MA)

Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Claudia Cicala (C)

Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

James Arthos (J)

Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Guido Ferrari (G)

Division of Surgical Sciences, Duke University School of Medicine, Durham, NC 27701, USA.

Leonid Margolis (L)

Section on Intercellular Interactions, Eunice Kennedy-Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

Marjorie Robert-Guroff (M)

Immune Biology of Retroviral Infection Section, National Cancer Institute, Bethesda, MD 20892, USA.

Peter D Kwong (PD)

Structural Biology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Mario Roederer (M)

ImmunoTechnology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Mangala Rao (M)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Timothy J Cardozo (TJ)

New York University School of Medicine, NYU Langone Health, New York, NY 10016, USA.

Genoveffa Franchini (G)

Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA.

Classifications MeSH