Mesenchymal stem cells protect renal tubular cells via TSG-6 regulating macrophage function and phenotype switching.
Animals
Coculture Techniques
Cytokines
/ metabolism
Epithelial Cells
/ cytology
Humans
Kidney
/ metabolism
Macrophages
/ cytology
Mesenchymal Stem Cells
/ cytology
Metabolic Syndrome
/ drug therapy
Phenotype
Protective Agents
/ pharmacology
Renal Artery Obstruction
/ metabolism
Swine
Tumor Necrosis Factor-alpha
/ metabolism
macrophage
mesenchymal stem cells
metabolic syndrome
renal artery stenosis
tumor necrosis factor-α-induced gene/protein-6
Journal
American journal of physiology. Renal physiology
ISSN: 1522-1466
Titre abrégé: Am J Physiol Renal Physiol
Pays: United States
ID NLM: 100901990
Informations de publication
Date de publication:
01 03 2021
01 03 2021
Historique:
pubmed:
9
2
2021
medline:
29
4
2021
entrez:
8
2
2021
Statut:
ppublish
Résumé
Tumor necrosis factor (TNF)-α-induced gene/protein (TSG)-6 regulates the immunomodulatory properties of mesenchymal stem cells (MSCs), but its ability to protect the ischemic kidney is unknown. In a swine model of renal artery stenosis (RAS) and metabolic syndrome (MetS), we assessed the contribution of TSG-6 produced by MSCs to their immunomodulatory properties. Pigs were studied after 16 wk of diet-induced MetS and unilateral RAS and were either untreated or treated 4 wk earlier with intrarenal autologous adipose tissue-derived MSCs (
Identifiants
pubmed: 33554782
doi: 10.1152/ajprenal.00426.2020
pmc: PMC7988807
doi:
Substances chimiques
Cytokines
0
Protective Agents
0
Tumor Necrosis Factor-alpha
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
F454-F463Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK122734
Pays : United States
Organisme : HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
ID : DK104273
Organisme : NIDDK NIH HHS
ID : U01 DK104273
Pays : United States
Organisme : HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
ID : DK120292
Organisme : NIA NIH HHS
ID : R21 AG062104
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK120292
Pays : United States
Organisme : HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
ID : DK102325
Organisme : HHS | NIH | National Institute on Aging (NIA)
ID : AG062104
Organisme : NIDDK NIH HHS
ID : R01 DK102325
Pays : United States
Organisme : HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
ID : DK122734
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