Goat Milk Improves Glucose Homeostasis via Enhancement of Hepatic and Skeletal Muscle AMP-Activated Protein Kinase Activation and Modulation of Gut Microbiota in Streptozocin-Induced Diabetic Rats.
AMP-Activated Protein Kinases
/ metabolism
Animals
Blood Glucose
/ metabolism
Diabetes Mellitus, Experimental
/ diet therapy
Diabetes Mellitus, Type 1
/ diet therapy
Enzyme Activation
/ physiology
Fatty Acids, Volatile
/ metabolism
Feces
/ chemistry
Gastrointestinal Microbiome
/ physiology
Goats
Homeostasis
Liver
/ metabolism
Milk
Muscle, Skeletal
/ metabolism
Rats, Sprague-Dawley
Streptozocin
Lactobacillus
caprine
dysbiosis
glucagon-like peptide 1
short-chain fatty acids
Journal
Molecular nutrition & food research
ISSN: 1613-4133
Titre abrégé: Mol Nutr Food Res
Pays: Germany
ID NLM: 101231818
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
revised:
21
12
2020
received:
14
09
2020
pubmed:
9
2
2021
medline:
10
11
2021
entrez:
8
2
2021
Statut:
ppublish
Résumé
Previously, the metabolic benefits of goat milk consumption in high-fat diet-fed rats are demonstrated. However, the effects are only reported in one animal model and the involvement of gut microbiota is not investigated. The aim of this study is to investigate the effects of goat milk consumption on glucose homeostasis and gut microbiota in streptozocin (STZ)-induced diabetic rats. STZ-induced diabetic rats are fed with three dosages of goat milk: 2.5, 5, and 10 g kg This study demonstrates the metabolic benefits of goat milk consumption in STZ-induced diabetic rats, which is consistent with the previous observations in high-fat diet-induced diabetic rats. Furthermore, this study elucidates the modulation of gut microbiota by goat milk, which likely mediates the metabolic effects of goat milk.
Identifiants
pubmed: 33555137
doi: 10.1002/mnfr.202000888
doi:
Substances chimiques
Blood Glucose
0
Fatty Acids, Volatile
0
Streptozocin
5W494URQ81
AMP-Activated Protein Kinases
EC 2.7.11.31
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2000888Informations de copyright
© 2021 Wiley-VCH GmbH.
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