Loss of cortical control over the descending pain modulatory system determines the development of the neuropathic pain state in rats.
descending pain modulation
neuropathic
neuroscience
pain
periaquductal gray
prefrontal cortex
rat
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
08 02 2021
08 02 2021
Historique:
received:
24
11
2020
accepted:
07
02
2021
pubmed:
9
2
2021
medline:
9
2
2022
entrez:
8
2
2021
Statut:
epublish
Résumé
The loss of descending inhibitory control is thought critical to the development of chronic pain but what causes this loss in function is not well understood. We have investigated the dynamic contribution of prelimbic cortical neuronal projections to the periaqueductal grey (PrL-P) to the development of neuropathic pain in rats using combined opto- and chemogenetic approaches. We found PrL-P neurons to exert a tonic inhibitory control on thermal withdrawal thresholds in uninjured animals. Following nerve injury, ongoing activity in PrL-P neurons masked latent hypersensitivity and improved affective state. However, this function is lost as the development of sensory hypersensitivity emerges. Despite this loss of tonic control, opto-activation of PrL-P neurons at late post-injury timepoints could restore the anti-allodynic effects by inhibition of spinal nociceptive processing. We suggest that the loss of cortical drive to the descending pain modulatory system underpins the expression of neuropathic sensitisation after nerve injury.
Identifiants
pubmed: 33555256
doi: 10.7554/eLife.65156
pii: 65156
pmc: PMC7895525
doi:
pii:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical Research Council
ID : MR/P00668X/1
Pays : United Kingdom
Informations de copyright
© 2021, Drake et al.
Déclaration de conflit d'intérêts
RD, KS, RA, BL, AP No competing interests declared
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