Effects of acquired vestibular pathology on the organization of mouse exploratory behavior.
Dark testing
Light testing
Movement topography
Path integration
Progressions
Stops
Vestibular
Journal
Experimental brain research
ISSN: 1432-1106
Titre abrégé: Exp Brain Res
Pays: Germany
ID NLM: 0043312
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
13
10
2020
accepted:
30
12
2020
pubmed:
9
2
2021
medline:
29
7
2021
entrez:
8
2
2021
Statut:
ppublish
Résumé
Rodent open field behavior is highly organized and occurs spontaneously in novel environments. This organization is disrupted in mice with vestibular pathology, suggesting vestibular signals provide important contributions to this behavior. A caveat to this interpretation is that previous studies have investigated open field behavior in adult mice with congenital vestibular dysfunction, and the observed deficits may have resulted from developmental changes instead of the lack of vestibular signals. To determine which aspects of open field behavior depend specifically on vestibular signals, mouse movement organization was examined under dark and light conditions at two time points, 1 and 2 months, after bilateral chemical labyrinthectomy. Our results show that acquired vestibular damage selectively disrupted the organization of open field behavior. Access to visual environmental cues attenuated, but did not eliminate, these significant group differences. Improvement in movement organization from the first to the second testing session was limited to progression path circuity. These observations provide evidence for the role of the vestibular system in maintaining spatial orientation and establishes a foundation to investigate neuroplasticity in brain systems that process self-movement information.
Identifiants
pubmed: 33555382
doi: 10.1007/s00221-020-06032-1
pii: 10.1007/s00221-020-06032-1
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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