Factors associated with subjective cognitive decline in dementia-free older adults-A population-based study.
dementia
depression
elderly
personality
quality of life
subjective cognitive decline
Journal
International journal of geriatric psychiatry
ISSN: 1099-1166
Titre abrégé: Int J Geriatr Psychiatry
Pays: England
ID NLM: 8710629
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
06
01
2021
accepted:
31
01
2021
pubmed:
9
2
2021
medline:
10
8
2021
entrez:
8
2
2021
Statut:
ppublish
Résumé
Subjective cognitive decline (SCD) is common in older adults, affects quality of life (QoL), and may represent the earliest clinical manifestation of cognitive decline evolving to dementia. Still little is known about factors associated with SCD. (1) Assess the associations between SCD and demographic, social, clinical, and personality characteristics as well as QoL, with and without adjustment for objective cognitive performance, and (2) investigate the relations between neuroticism, QoL, and SCD. Cross-sectional analysis of a cohort of 1567 dementia-free community-dwellers from the urban area of Lausanne, Switzerland, aged 64 years and older (mean age 70.9 ± 4.7 years), from CoLaus/PsyCoLaus. SCD was assessed using a validated 10-item questionnaire. Personality traits, QoL, and perceived social support were evaluated using self-report measures. Information on depression and anxiety status and socioeconomic characteristics including professional activity were elicited using a semi-structured interview. Cognitive functioning was assessed through a comprehensive neuropsychological test battery. Statistical analysis was based on logistic regression. SCD was present in 18.5% of the sample and it was associated with lower performance in memory and verbal fluency tasks. After controlling for possible confounders, professional activity, neuroticism, and current depression were associated with SCD. Exploratory analysis revealed associations of SCD with QoL, neuroticism, and their interaction. Besides objective cognitive performance, SCD is related to several psychosocial factors in dementia-free community-dwelling older people. These findings are relevant for the development of healthcare interventions to reduce cognitive complaints, improve QoL, and prevent cognitive decline in general population.
Sections du résumé
BACKGROUND
Subjective cognitive decline (SCD) is common in older adults, affects quality of life (QoL), and may represent the earliest clinical manifestation of cognitive decline evolving to dementia. Still little is known about factors associated with SCD.
OBJECTIVES
(1) Assess the associations between SCD and demographic, social, clinical, and personality characteristics as well as QoL, with and without adjustment for objective cognitive performance, and (2) investigate the relations between neuroticism, QoL, and SCD.
METHODS
Cross-sectional analysis of a cohort of 1567 dementia-free community-dwellers from the urban area of Lausanne, Switzerland, aged 64 years and older (mean age 70.9 ± 4.7 years), from CoLaus/PsyCoLaus. SCD was assessed using a validated 10-item questionnaire. Personality traits, QoL, and perceived social support were evaluated using self-report measures. Information on depression and anxiety status and socioeconomic characteristics including professional activity were elicited using a semi-structured interview. Cognitive functioning was assessed through a comprehensive neuropsychological test battery. Statistical analysis was based on logistic regression.
RESULTS
SCD was present in 18.5% of the sample and it was associated with lower performance in memory and verbal fluency tasks. After controlling for possible confounders, professional activity, neuroticism, and current depression were associated with SCD. Exploratory analysis revealed associations of SCD with QoL, neuroticism, and their interaction.
CONCLUSION
Besides objective cognitive performance, SCD is related to several psychosocial factors in dementia-free community-dwelling older people. These findings are relevant for the development of healthcare interventions to reduce cognitive complaints, improve QoL, and prevent cognitive decline in general population.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1188-1196Informations de copyright
© 2021 John Wiley & Sons Ltd.
Références
Röhr S, Pabst A, Riedel-Heller SG, et al. Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC study. Alzheimers Res Ther. 2020;12(1):167.
van Harten AC, Mielke MM, Swenson-Dravis DM, et al. Subjective cognitive decline and risk of MCI. Neurology. 2018;91(4):e300-e312.
Slot RER, Sikkes SAM, Berkhof J, et al. Subjective cognitive decline and rates of incident Alzheimer's disease and non-Alzheimer's disease dementia. Alzheimers Dement. 2019;15(3):465-476.
Jessen F, Amariglio RE, van Boxtel M, et al. A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease. Alzheimers Demen. 2014;10(6):844-852.
Lista S, Molinuevo JL, Cavedo E, et al. Evolving evidence for the value of neuroimaging methods and biological markers in subjects categorized with subjective cognitive decline. J Alzheimers Dis. 2015;48(suppl 1):S171-S191.
Visser PJ, Verhey F, Knol DL, et al. Prevalence and prognostic value of CSF markers of Alzheimer's disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study: a prospective cohort study. Lancet Neurol 2009;8(7):619-627.
Molinuevo JL, Rabin LA, Amariglio R, et al Implementation of subjective cognitive decline criteria in research studies. Alzheimers Dement. 2017;13(3):296-311.
Jessen F, Wiese B, Cvetanovska G, et al. Patterns of subjective memory impairment in the elderly: association with memory performance. Psychol Med. 2007;37(12):1753-1762.
Minett TS, Da Silva RV, Ortiz KZ, et al. Subjective memory complaints in an elderly sample: a cross-sectional study. Int J Geriatr Psychiatry. 2008;23(1):49-54.
Mendes T, Gino S, Ribeiro F, et al. Memory complaints in healthy young and elderly adults: reliability of memory reporting. Aging Ment Health. 2008;12(2):177-182.
Hill NL, Mogle J, Wion R, et al. Subjective cognitive impairment and affective symptoms: a systematic review. Gerontologist. 2016;56(6):e109-e127.
Studer J, Donati A, Popp J, et al. Subjective cognitive decline in patients with mild cognitive impairment and healthy older adults: association with personality traits. Geriatr Gerontol Int. 2014;14(3):589-595.
Pearman A, Storandt M. Self-discipline and self-consciousness predict subjective memory in older adults. J Gerontol B Psychol Sci Soc Sci. 2005;60(3):153-157.
Jorm AF, Butterworth P, Anstey KJ, et al. Memory complaints in a community sample aged 60-64 years: associations with cognitive functioning, psychiatric symptoms, medical conditions, APOE genotype, hippocampus and amygdala volumes, and white-matter hyperintensities. Psychol Med. 2004;34(8):1495-1506.
Maki Y, Yamaguchi T, Yamagami T, et al. The impact of subjective memory complaints on quality of life in community-dwelling older adults. Psychogeriatrics. 2014;14(3):175-181.
Mol M, Carpay M, Ramakers I, et al. The effect of perceived forgetfulness on quality of life in older adults; a qualitative review. Int J Geriatr Psychiatry. 2007;22(5):393-400.
Montejo P, Montenegro M, Fernandez MA, et al. Memory complaints in the elderly: quality of life and daily living activities. A population based study. Arch Gerontol Geriatr. 2012;54(2):298-304.
Caramelli P, Beato RG. Subjective memory complaints and cognitive performance in a sample of healthy elderly. Dement Neuropsychol. 2008;2(1):42-45.
Jessen F, Amariglio RE, Buckley RF, et al. The characterization of subjective cognitive decline. Lancet Neurol 2020;19(3):271-278.
Pocnet C, Antonietti JP, Strippoli MF, et al. Individuals' quality of life linked to major life events, perceived social support, and personality traits. Qual Life Res. 2016;25(11):2897-2908.
Firmann M, Mayor V, Vidal PM, et al. The CoLaus study: a population-based study to investigate the epidemiology and genetic determinants of cardiovascular risk factors and metabolic syndrome. BMC Cardiovasc Disord. 2008;8:6.
Preisig M, Waeber G, Vollenweider P, et al. The PsyCoLaus study: methodology and characteristics of the sample of a population-based survey on psychiatric disorders and their association with genetic and cardiovascular risk factors. BMC Psychiatry. 2009;9:9.
Nurnberger JI, Jr, Blehar MC, Kaufmann CA, et al. Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative. Arch Gen Psych. 1994;51:849-859.
Hollingshead A. Four-factor Index of Social Status. New Haven, CT: Yale University; 1975.
Costa PT, McCrae RR. Revised NEO Personality Inventory (NEO-PI-R) and NEO Five-Factor Inventory (NEO-FFI) Professional Manual. Odessa, FL: Psychological Assessment Resources; 1992.
Eysenck HJ, Eysenck SBG. Manual of the Eysenck Personality Scale (Adults). London, UK: Hodder and Stoughton; 1991.
Zimet GD, Dahlem NW, Zimet SG, et al. The multidimensional scale of perceived social support. J Personality Assess. 1988;52(1):30-41.
Priebe S, Huxley P, Knight S, et al. Application and results of the Manchester Short assessment of quality of life (MANSA). Int J Soc Psychiatry. 1999;45(1):7-12.
Buschke H, Sliwinski MJ, Kuslansky G, et al. Diagnosis of early dementia by the Double Memory Test: encoding specificity improves diagnostic sensitivity and specificity. Neurology. 1997;48(4):989-997.
Deloche G, Hannequin D. Test de dénomination orale d'images: DO 80. Paris: Éd. du Centre de psychologie appliquée; 1997.
Stroop JR. Studies of interference in serial verbal reaction. J Exp Psychol. 1935;18:643-662.
Morris JC, Mohs RC, Rogers H, et al. Consortium to establish a registry for Alzheimer's disease (CERAD) clinical and neuropsychological assessment of Alzheimer's disease. Psychopharmacol Bull. 1988;24(4):641-652.
Morris JC. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology. 1993;43(11):2412-2414.
Assmann G, Schulte H, Cullen P, et al. Assessing risk of myocardial infarction and stroke: new data from the Prospective Cardiovascular Munster (PROCAM) study. Eur J Clin Invest. 2007;37(12):925-932.
R Core Team. R. A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing; 2020. https://www.R-project.org/.
Montejo CP, Montenegro-Pena M, Lopez-Higes R, et al. Subjective memory complaints in healthy older adults: fewer complaints associated with depression and perceived health, more complaints also associated with lower memory performance. Arch Gerontol Geriatr. 2017;70:28-37.
Montejo P, Montenegro M, Fernandez-Blazquez MA, et al. Association of perceived health and depression with older adults’ subjective memory complaints: contrasting a specific questionnaire with general complaint questions. Eur J Ageing. 2014;11:77-87.
Reid LM, Maclullich AM. Subjective memory complaints and cognitive impairment in older people. Dement Geriatr Cogn Disord. 2006;22(5-6):471-485.
Balash Y, Mordechovich M, Shabtai H, et al. Subjective memory complaints in elders: depression, anxiety, or cognitive decline?. Acta Neurol Scand. 2013;127(5):344-350.
Bolla KI, Lindgren KN, Bonaccorsy C, et al. Memory complaints in older adults. Fact or fiction? Arch Neurol. 1991;48(1):61-64.
O'Connor DW, Pollitt PA, Roth M, et al. Memory complaints and impairment in normal, depressed, and demented elderly persons identified in a community survey. Arch Gen Psychiatry. 1990;47(3):224-227.
Chapman BP, Roberts B, Duberstein P. Personality and longevity: knowns, unknowns, and implications for public health and personalized medicine. J Aging Res. 2011;2011:759170.
Hampson SE. Personality processes: mechanisms by which personality traits "get outside the skin. Annu Rev Psychol. 2012;63:315-339.
Beydoun MA, Beydoun HA, Gamaldo AA, et al. Epidemiologic studies of modifiable factors associated with cognition and dementia: systematic review and meta-analysis. BMC Public Health. 2014;14:643.
Terracciano A, Sutin AR, An Y, et al. Personality and risk of Alzheimer's disease: new data and meta-analysis. Alzheimers Dement. 2014;10(2):179-186.
Donati A, Studer J, Petrillo S, et al. The evolution of personality in patients with mild cognitive impairment. Dement Geriatr Cogn Disord. 2013;36(5-6):329-339.
Pocnet C, Rossier J, Antonietti JP, et al. Personality changes in patients with beginning Alzheimer disease. Can J Psychiatry. 2011;56(7):408-417.
Tautvydaite D, Antonietti JP, Henry H, et al. Relations between personality changes and cerebrospinal fluid biomarkers of Alzheimer's disease pathology. J Psychiatr Res. 2017;90:12-20.
Snitz BE, Weissfeld LA, Cohen AD, et al. Subjective cognitive complaints, personality and brain amyloid-beta in cognitively normal older adults. Am J Geriatr Psychiatry. 2015;23(9):985-993.
Jungwirth S, Fischer P, Weissgram S, et al. Subjective memory complaints and objective memory impairment in the Vienna-Transdanube aging community. J Am Geriatr Soc. 2004;52(2):263-268.
Tandetnik C, Hergueta T, Bonnet P, et al. Influence of early maladaptive schemas, depression, and anxiety on the intensity of self-reported cognitive complaint in older adults with subjective cognitive decline. Int Psychogeriatr. 2017;29(10):1657-1667.
Gagnon M, Dartigues JF, Mazaux JM, et al. Self-reported memory complaints and memory performance in elderly French community residents: results of the PAQUID Research Program. Neuroepidemiology. 1994;13(4):145-154.
Jonker C, Launer LJ, Hooijer C, et al. Memory complaints and memory impairment in older individuals. J Am Geriatr Soc. 1996;44(1):44-49.
Rapp MA, Reischies FM. Attention and executive control predict Alzheimer disease in late life: results from the Berlin Aging Study (BASE). Am J Geriatr Psychiatry. 2005;13(2):134-141.
Blacker D, Lee H, Muzikansky A, et al. Neuropsychological measures in normal individuals that predict subsequent cognitive decline. Arch Neurol. 2007;64(6):862-871.